Publications by authors named "Miata Smith"
Microorganisms
December 2023
Article Synopsis
- Alphaviruses and bunyaviruses, which lack FDA-approved treatments, can cause serious illnesses like encephalitis and hemorrhagic fever, with specific viruses linked to severe health outcomes.
- Brilacidin, a small molecule designed based on natural host defenses, showed antiviral activity against several alphaviruses (like VEEV and SINV) and the bunyavirus RVFV when tested in human and monkey cells.
- The effectiveness of brilacidin depended on the timing of administration, requiring doses both before and after infection for better results, and exhibited only modest activity against a non-enveloped virus, suggesting it may be less effective in those cases.
