[The contribution of I.I. Molleson in becoming and development of sanitary service in the Saratov guberniia].

The article presents in the historical perspective a brief biography data about I.I. Molleson.

[Tissue pO2 and fetal heart activity during induction of labor with oxytocin].

A total of 65 women in labor complicated with uterine inertia were investigated for tissue pO2 and cardiac performance of fetuses under the effect of oxytocin. The authors stated that the aggravation of fetal status in drug-induced labors resulted from poorer tissue oxygenation caused by the activation of uterine contractility. In this line, hypoxic changes of the fetus were more pronounced in pregnancies complicated by nephropathy or prolonged pregnancy.

[Persistence of the genes of epidemic influenza viruses (H1N1) in natural populations].

A comparative study of antigenic determinants and genome of the analogues of epidemic H1N1 variants isolated from various animal species and from man in the USSR and Mongolia in 1978--1980 was carried out. The analysis of the antigenic determinants of hemagglutinins of the viruses isolated in this period from man, domestic and wild birds and animals performed with a set of monoclonal antibodies to the epidemic reference A/Brazil/11/78 virus revealed their close similarity in the structure of the antigenic sites. Study of neuraminidase of these viruses with a set of monoclonal antibodies to the A/Denver/1/57 strain showed their relationship with neuraminidase of the viruses isolated in 1957 and revealed its trend for changes in individual antigenic determinants.

[Influenza viruses isolated from wild birds].

Ninety-eight hemagglutinating agents were isolated from washings of cloaca and organs of 750 birds collected in southern and southeastern regions of the Kazakh SSR. Determinations of their type appurtenance allowed 36 agents to be classified into influenza A virus. Among them 4 strains had H1N1 surface antigens, 29 strains were Hav2 Nav5 and 3 strains had unidentified neuraminidase and Hav2.

[Isolation of the influenza virus from ducks in the Aral Sea region].

Influenza A/duck/Aralsk/1/78 virus was isolated from ducks in southwestern Kazakhstan. Typing of this virus neuraminidase indicated its appurtenance to the 2nd avian type. Hemagglutinin of A/duck/Aralsk/1/78 virus typed by the HI test showed no relationship with any one of the strains used in the test including H0, H1, H2, H3, Hsw1, Heq1, Heq2, viruses and strains with all 10 avian hemagglutinins.

[Interrelationships between the interfering capacity of an "incomplete" virus and its infectivity].

A comparative analysis of UV inactivation curves of the interfering activity of "incomplete" influenza virus and infectivity showed certain differences in the structures responsible for these functions. All the data exclude the role of virus protein and virus-induced interferon of "incomplete" influenza virus and suggest that RNA is responsible for this interference. The size of the "target" of the "incomplete" virus interfering capacity calculated on the basis of sensitivity to UV-light is approximately 40 times as small as that of the "target" responsible for infectivity.

[Properties of the influenza viruses isolated in 1976 from gulls in Astrakhan Province].

Investigation of a number of properties of influenza viruses isolated from Laridae birds in the Astrakhan region showed that in one epizootic focus avian influenza viruses with different hemagglutinins and identical neuraminidase may circulate among Laridae birds. Among viruses with the antigenic formula Hav5Nav2 clear-cut differences in virulence and plaque-forming capacity were demonstrated.

[Use of the plaque method to reveal the phenomenon of autointerference in influenza virus].

The paper describes a simple and convenient method for qualitative and quantitative evaluation of the capacity of influenza virus for autointerference consisting in the lack or considerable reduction of the cytolytic effect of the virus under agar overlay at a high multiplicity of infection. Some experimental and theoretical arguments assuming the role of defective interfering particles in the formation of the observed phenomenon. It is assumed that the detection of autointerference under agar may be used as an additional criterion for detection of non-plaque-forming strains of influenza virus, tentative determination of their interfering capacity as well as for the establishment of biological relationships of viruses.