Publications by authors named "Miaotong Su"
Article Synopsis
- This study investigates the oral microflora of patients with primary Sjögren's syndrome (pSS), an autoimmune disease, to understand how it might relate to dental health.
- Researchers analyzed saliva and plaque samples from 35 pSS patients and 20 healthy controls using advanced DNA sequencing techniques to examine microbial composition.
- Results showed that pSS patients had lower diversity in their oral bacteria and specific bacteria like Prevotella and Veillonella were more prevalent, suggesting a potential link between their oral health and the disease.
Objectives: Rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and primary Sjögren's syndrome (pSS) share many clinical manifestations and serological features. The aim of this study was to identify the common transcriptional profiling and composition of immune cells in peripheral blood in these autoimmune diseases (ADs).
Methods: We analysed bulk RNA-seq data for enrichment of biological processes, transcription factors (TFs) and deconvolution-based immune cell types from peripheral blood mononuclear cells (PBMCs) in 119 treatment-naive patients (41 RA, 38 pSS, 28 SLE and 12 polyautoimmunity) and 20 healthy controls.