Publications by authors named "Miaomiao Liang"

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Background: Proprotein convertase subtilisins/kexin 6 (PCSK6) polymorphisms have been shown to be associated with atherosclerosis progression. This research aimed to evaluate the relationship of PCSK6 rs1531817 polymorphisms with coronary stenosis and the prognosis in premature myocardial infarction (PMI) patients.

Methods: This prospective cohort analysis consecutively included 605 PMI patients who performed emergency percutaneous coronary intervention (PCI) at Tianjin Chest Hospital sequentially between January 2017 and August 2022, with major adverse cardiovascular events (MACEs) as the outcome.

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Presented herein are novel syntheses of CF-isoquinolinones and imidazole fused CF-isoquinolinones based on the cascade reactions of 2-aryloxazolines with trifluoromethyl imidoyl sulfoxonium ylides. The formation of CF-isoquinolinone involves an intriguing cascade process including oxazolinyl group-assisted aryl alkylation through C(sp)-H bond metalation, carbene formation, migratory insertion, and proto-demetalation followed by intramolecular condensation and water-promoted oxazolinyl ring-scission. With this method, the isoquinolinone scaffold tethered with valuable functional groups was effectively constructed.

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Background: In recent years, 5-Methoxytryptophan (5-MTP) has been identified as an endothelial factor with vaso-protective and anti-inflammatory properties.

Methods: In this prospective cohort study, a total of 407 patients with acute myocardial infarction (AMI) who underwent percutaneous coronary intervention (PCI) successfully were enrolled. A 1-year follow-up Kaplan-Meier survival analysis was used for evaluating the correlation between 5-MTP and major adverse cardiovascular event (MACE) while Cox proportional-hazards regression was used to identify predictive values of 5-MTP on MACE after AMI.

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Background: Bile acids play crucial roles in various metabolisms, as well as in the intestine. But studies on their roles in acute coronary syndrome (ACS) are still insufficient. The aim of this study was to investigate their role and potential association with the severity of coronary lesions and the prognosis of ACS.

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The nanorod-structured (Au-Pd)/CeO catalysts with different Au/Pd ratios were prepared from Al-Ce-Au-Pd precursor alloys through combined dealloying and calcination treatment. XRD, SEM, TEM, XPS, Raman spectroscopy, and N adsorption-desorption measurements were applied to test the structure and physicochemical properties of samples. Catalytic evaluation results imply that the (Pd-Au)/CeO catalyst calcined at 500 °C possesses optimal catalytic activity for CO oxidation when compared with other catalysts with different Au/Pd ratios or (Pd-Au)/CeO calcined at other temperatures, whose 50% and 99% reaction temperature can be reached as low as 50 and 85 °C, respectively.

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Background: Multiple regimens have been widely used in the eradication treatment of infection in children. However, there is a lack of comparison and evaluation of their effectiveness in different regions of the world.

Methods: Randomized controlled trials were retrieved.

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Supported Pt-based catalysts have been identified as highly selective catalysts for CO oxidation, but their potential for applications has been hampered by the high cost and scarcity of Pt metals as well as aggregation problems at relatively high temperatures. In this work, nanorod structured (TiO-Pt)/CeO catalysts with the addition of 0.3 at% Pt and different atomic ratios of Ti were prepared through a combined dealloying and calcination method.

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Gametogenesis is an essential step for malaria parasite transmission and is activated in mosquito by signals including temperature drop, pH change, and mosquito-derived xanthurenic acid (XA). Recently, a membrane protein gametogenesis essential protein 1 (GEP1) was found to be responsible for sensing these signals and interacting with a giant guanylate cyclase α (GCα) to activate the cGMP-PKG-Ca signaling pathway for malaria parasite gametogenesis. However, the molecular mechanisms for this process remain unclear.

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Nanorod-supported (Pt-Pd)/CeO catalysts were synthesized by a simple method of dealloying AlCe Pt Pd ( = 0, 0.075, 0.1, 0.

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Necroptosis and inflammation are closely related to the pathogenesis of respiratory syncytial virus (RSV). Acteoside (AC), a natural phenylpropanoid glycoside from Kuding Tea, has significant anti-RSV effect. However, the roles of AC on RSV-induced lung necroptosis and inflammation are yet to be elucidated.

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In China, food has become safer over the past five years, especially commonly consumed foods. Food supervision sampling has played an important role in improving food safety. However, consumer acceptance of the results of food safety supervision have not kept pace.

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Separase is a giant cysteine protease and has multiple crucial functions. The most well-known substrate of separase is the kleisin subunit of cohesin, the cleavage of which triggers chromosome segregation during cell division (Uhlmann et al., 1999; Kamenz and Hauf, 2016) [1,2].

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Background: The evolution of resistance to antimicrobials is a ubiquitous phenomenon. The evolution of antibiotic resistance in Staphylococcus aureus suggests that there is no remedy with sustaining effectiveness against this pathogen. The limited number of antibacterial drug classes and the common occurrence of cross-resistant bacteria reinforce the urgent need to discover new compounds targeting novel cellular functions.

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Triterpenoids are biologically active metabolites synthesized from a common linear precursor catalyzed by 2,3-oxidosqualene cyclases (OSCs) to form diverse triterpenoid skeletons. OSCs corresponding to many discovered triterpene alcohols in nature have not been functionally and mechanistically characterized due to the diversity of chemical structures and complexity of the cyclization mechanism. We carried out a genome-wide investigation of OSCs from Avena strigosa and discovered two triterpene synthases, namely, AsHS1 and AsHS2, using a Nicotiana benthamiana expression system.

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Major depressive disorder (MDD) is one of the most common psychiatric disorders, the diagnosis and treatment of MDD are major clinical issues. However, there is a lack of effective biomarkers and drugs diagnosis and therapeutics of MDD. In the present study, bioinformatics analysis combined with an experimental verification strategy was used to identify biomarkers and paeoniflorin targets for MDD diagnosis and treatment.

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NiS/NiO nanoparticles are successfully fabricated through a simple dealloying method and an ion-exchange process. X-ray diffraction demonstrates the existence of NiO and NiS phases, and scanning electron microscopy and transmission electron microscopy imply the nanopore distribution nature and the nanoparticle morphology of the produced material. The electrochemical behaviors are studied by cyclic voltammetry and galvanostatic charge-discharge measurements.

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Background: This study utilized bibliometric analysis to qualitatively and quantitatively analyze hotspots and predict trends in the field of ankylosing spondylitis (AS) research.

Methods: Articles about AS were obtained from the Web of Science Core Collection and PubMed database, and bibliometric analysis was carried out through CiteSpace and the Online Analysis Platform of Literature Metrology and Bibliographic Item Co-Occurrence Matrix Builder (BICOMB). Then, co-word biclustering analysis was conducted to obtain research hotspots and predict trends using gCLUTO software.

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To better address the recognition of abnormalities among mammographic images, in this study we apply the deep fusion learning approach based on Pre-trained models to discover the discriminative patterns between Normal and Tumor categories. We designed a deep fusion learning framework for mammographic image classification. This framework works in two main steps.

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In situ monitoring of electrocatalytic processes at solid-liquid interfaces is essential for the fundamental understanding of reaction mechanisms, yet quite challenging. Herein, Pt-on-Au nanocatalysts with a Au-core Pt-satellite superstructure have been fabricated. In such Pt-on-Au nanocatalysts, the Au cores can greatly amplify the Raman signals of the species adsorbed on Pt, allowing the in situ surface-enhanced Raman spectroscopy (SERS) study of the electrocatalytic reactions on Pt.

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The present study aimed to investigate the association between microRNA-152 and cisplatin resistance in non-small cell lung cancer. A549 and cisplatin-resistant A549 cells (A549/cis) were maintained . Reverse transcription-quantitative PCR (RT-qPCR) was performed to analyze differences in microRNA-152 levels between A549 and A549/cis cells, and changes in Bcl-2 and NF-κB expression levels were analyzed via RT-qPCR and western blot analyses.

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Pt/CeO catalysts with nanoporous structures were prepared by the facile dealloying of melt-spun AlCePt (X = 0.1; 0.3 and 0.

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In this work, NiCoS nanoparticles for supercapacitors are successfully synthesized with a top-down strategy, using a novel dealloying method with an ion exchange reaction. The surface morphology and x-ray diffraction investigations demonstrated that NiCoS nanoparticles are interconnected by ligaments of the synthesized sample. The dealloyed NiCoS shows an enhanced electrochemical performance of about 1132.

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Heterogeneous metal interfaces play a key role in determining the mechanism and performance of catalysts. However, in situ characterization of such interfaces at the molecular level is challenging. Herein, two model interfaces, Pd and Pt overlayers on Au single crystals, were constructed.

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