Screening potential lncRNA biomarkers for breast cancer and colorectal cancer combining random walk and logistic matrix factorization.

Breast cancer and colorectal cancer are two of the most common malignant tumors worldwide. They cause the leading causes of cancer mortality. Many researches have demonstrated that long noncoding RNAs (lncRNAs) have close linkages with the occurrence and development of the two cancers.

A Novel Algorithm for Detecting Microsatellite Instability Based on Next-Generation Sequencing Data.

Objectives: Microsatellite instability (MSI) is the condition of genetic hypermutability caused by spontaneous acquisition or loss of nucleotides during the DNA replication. MSI has been discovered to be a useful immunotherapy biomarker clinically. The main DNA-based method for MSI detection is polymerase chain reaction (PCR) amplification and fragment length analysis, which are costly and laborious.

Preparation and Characterization of Bio-oil Phenolic Foam Reinforced with Montmorillonite.

Introducing bio-oil into phenolic foam (PF) can effectively improve the toughness of PF, but its flame retardant performance will be adversely affected and show a decrease. To offset the decrease in flame retardant performance, montmorillonite (MMT) can be added as a promising alternative to enhance the flame resistance of foams. The present work reported the effects of MMT on the chemical structure, morphological property, mechanical performance, flame resistance, and thermal stability of bio-oil phenolic foam (BPF).

Aging Properties of Phenol-Formaldehyde Resin Modified by Bio-Oil Using UV Weathering.

The aging properties of phenol-formaldehyde resin modified by bio-oil (BPF) were analyzed using ultraviolet (UV) weathering. The variations on bonding strength of BPF were measured, and the changes on microstructure, atomic composition and chemical structure of BPF were characterized by using a scanning electron microscope (SEM), X-ray photoelectron spectroscopy (XPS) and nuclear magnetic resonance (NMR), respectively. With the increase of aging time, the bonding strength decreased gradually, the resin surface became rougher and the O/C radio of resin surface increased.

Down-regulation of hypoxia-inducible factor-1 suppresses malignant biological behavior of triple-negative breast cancer cells.

This study is to investigate the effect and mechanism of reduced hypoxia-inducible factor (HIF)-1a expression on malignant behavior of MDA-MB-231 cells. HIF-1α expression was interfered by siRNA. Western blot was used to detect protein expression of HIF-1α, active fragments of caspase 3 and vimentin.

[Impact of hypoxia-inducible factor-1 on tumor invasion and metastasis in breast cancer].

Objective: To investigate HIF-1α gene expression in human breast cancer cells and the role of HIF-1 in tumor metastasis and invasion.

Methods: Human breast cancer cell lines were cultured under normoxic or hypoxic conditions. Western blot was used to evaluate the protein expression of HIF-1α, p-vimentin and α-tubulin.

Role and mechanism of hypoxia-inducible factor-1 in cell growth and apoptosis of breast cancer cell line MDA-MB-231.

The role of hypoxia-inducible factor-1 (HIF-1) in tumor development and progression is well-established but its effect on tumor growth remains controversial. The present study investigated the effect of HIF-1 on tumor growth using the estrogen receptor-negative breast cancer cell line, MDA-MB-231. Using Western blotting, we detected a higher level of HIF-1α protein in MDA-MB-231 cells than in any other breast cancer cell lines analyzed, and this was accompanied by a more rapid growth pattern.