Publications by authors named "Miaoling Lan"
The continual emergence of highly pathogenic novel coronaviruses and their variants has underscored the importance of neutralizing monoclonal antibodies (mAbs) as a pivotal therapeutic approach. In the present study, we report the specific neutralizing antibodies 13H7 and 9G11, which target the N-terminal domain (NTD) and receptor-binding domain (RBD) of the SARS-CoV-2, respectively. The comparative analysis observed that 13H7 not only neutralizes early variants of concern (VOCs) but also exhibits neutralizing activity against the Omicron sublineage, including BA.
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- The study evaluated the antibody response duration and effectiveness of inactivated COVID-19 vaccines among healthy blood donors, analyzing samples from 1,417 participants who received either 2 or 3 doses.
- Results showed that neutralizing antibodies peaked around one month post-vaccination but declined significantly over time, with notable drops in effectiveness against Omicron variants compared to earlier strains.
- The findings indicate that while a 3-dose regimen extends antibody duration, the ability of the antibodies to neutralize circulating Omicron variants is markedly reduced.