Obtaining HBV core protein VLPs carrying SARS-CoV-2 nucleocapsid conserved fragments as vaccine candidates.

The Hepatitis B core antigen (HBcAg) has been used as a carrier of several heterologous protein fragments based on its capacity to form virus-like particles (VLPs) and to activate innate and adaptive immune responses. In the present work, two chimeric proteins were designed as potential pancorona vaccine candidates, comprising the N- or C- terminal domain of SARS-CoV-2 nucleocapsid (N) protein fused to HBcAg. The recombinant proteins, obtained in E.

Design and development of bridge erecting machine with small curve radius and bottom feeding beam.

As a key equipment in highway and railway construction, bridge erecting machines directly affect the feasibility, progress, and quality of project implementation. In order to solve the problem that traditional bridge building machines are only suitable for application scenarios with large turning radii and large lifting sites, and have low lifting efficiency, which cannot meet the requirements of urban elevated bridge construction, a small radius bottom feeding beam bridge building machine suitable for urban highway and railway construction is proposed. The feasibility and reliability were verified through force analysis and finite element analysis; Design a secondary turning structure and bridge construction process for the front leg, adjusting the turning angle to around 7°, significantly reducing the turning radius of the bridge building machine; Propose a technology for feeding and lifting beams at the bottom of dual-use bridge decks for highways and railways.

[Protective effects and mechanisms of Xingnaojing Injection on early global brain ischemic-induced deep coma in rats].

To study the protective effect of Xingnaojing Injection on early global brain ischemia-induced deep coma in rats.
 Methods: The deep coma model was induced by global brain ischemia by using four-vessel occlusion method in male SD rats. According to the body weight, the rats were randomly divided into 8 groups: a model control group, three different dose of Xingnaojing Injection (1.

Effect of Ginkgo biloba extract-761 on motor functions in permanent middle cerebral artery occlusion rats.

Background: Ginkgo biloba extract (EGb-761) has been in use to treat variety of ailments including memory loss and emotional disorders usually experienced after ischemic stroke. However, data regarding its protective role in stroke associated motor dysfunction is scarce.

Purpose: The present work was designed to investigate the long-term effects of EGb-761 on the motor dysfunctions associated with permanent middle cerebral artery occlusion (pMCAO) in rats.