Publications by authors named "Miaochang Zhang"
Front Pharmacol
August 2024
Article Synopsis
- - Cervical cancer (CC) poses a major health risk for women worldwide, with high-risk human papillomaviruses (HPVs) as key causes, and the protein topoisomerase I (TOP1) being linked to various cancers.
- - Research showed that TOP1 is highly expressed in both cervical intraepithelial neoplasia (CIN) and CC, with its levels negatively affecting patient prognosis; inhibiting TOP1 hindered CC cell growth and DNA repair abilities.
- - TOP1 not only promotes inflammation and immune evasion in cervical cancer but is also influenced by HPV oncoproteins E6 and E7, making it a potential target for new therapeutic strategies involving the TOP1-cGAS
