[Study of senescence protein p66 on myocardial tissue repair in adult mice].

Our previous study has shown that p66 plays an important role in the process of myocardial regeneration in newborn mice, and p66 deficiency leads to weakened myocardial regeneration in newborn mice. This study aims to explore the role of p66 protein in myocardial injury repair after myocardial infarction in adult mice, in order to provide a new target for the treatment of myocardial injury after myocardial infarction. Mouse myocardial infarction models of adult wild-type (WT) and p66 knockout (KO) were constructed by anterior descending branch ligation.