4,4'‑Bond secalonic acid D targets SP cells and inhibits metastasis in hepatocellular carcinoma.

The existence of cancer stem cells (CSCs) is considered to be the main reason for chemoresistance, metastasis and the ultimate failure of treatment in hepatocellular carcinoma (HCC). However, there are a few chemical agents that may inhibit CSCs. The present study identified that 4,4'‑bond secalonic acid D (4,4'‑SAD), a compound isolated from the marine‑derived fungus Penicillium oxalicum, inhibited the growth of side population (SP) cells isolated from human liver cancer cell lines PLC/PRF/5 and HuH‑7 by attenuating the expression of ATP‑binding cassette superfamily G member 2.

[The NMD escape mechanism and its application in disease therapy].

Nonsense-mediated mRNA decay (NMD) refers to the degradation of mRNA due to the presence of premature stop codon (PTC) on mRNA under pathological or physiological conditions. NMD is widely considered an mRNA-specific quality control process. Recently it was discovered that some PTCs do not trigger NMD in a variety of diseases - a process known as NMD escape; however, its exact mechanism remains unclear.

[Effect of Bt rice straw returning in soil on the growth and reproduction of Eisenia fetida.].

Bacillus thuringiensis (Bt) protein can enter the soil through Bt crops straw returning to field, which may affect the growth and reproduction of soil animals, such as earthworms. Here, Bt rice (b2B138) and conventional rice (Anfeng A) straw were returned in soil to evaluate the impact of Bt rice on Eisenia fetida. Two varieties of rice straw were added into soil to breed E.

[Environmental effects of applying heavy metal-containing municipal sewage sludge on wheat-rice rotation system on different types of soil].

A pot experiment with the yellow soil and limestone soil from Guizhou province, and paddy soil from Zhejiang Province was conducted to study the impacts of applying municipal sewage sludge containing different concentrations of heavy metals on the wheat and rice growth and their Zn and Cd absorption. The risks of the crop heavy metals pollution caused by the application of the same sludge differed with tested soils. On the yellow soil and paddy soil, applying the sludge containing high concentration heavy metals induced higher pollution risks to the crops.

[Effects of intercropping Sedum plumbizincicola in wheat growth season under wheat-rice rotation on the crops growth and their heavy metals uptake from different soil types].

A pot experiment with heavy metals- contaminated black soil from Heilongjiang Province, alluvial soil from Henan Province, and paddy soil from Zhejiang Province was conducted to study the effects of intercropping Sedum plumbizincicola in wheat growth season under wheat (Triticum aestivum) - rice (Oryza sativa) rotation on the growth of the crops and their heavy metals uptake, aimed to explore the feasibility of simultaneous grain production and heavy metals-contaminated soil phytoremediation in main food crop production areas of this country. Comparing with monoculture T. aestivum, intercropping S.