Publications by authors named "Miao-Hui Cheng"
Group A Streptococcus (GAS) infection is associated with a variety of human diseases. Previous studies indicate GAS infection leads to RAW264.7 cell death, but the mechanism is unclear.
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- Group A streptococcus (GAS) is a harmful bacteria that uses exotoxins like streptococcal pyrogenic exotoxin B (SPE B) to invade the body and evade the immune system by cleaving complement 3 (C3).
- Research identified specific regions on SPE B that bind to human C3, with the C-terminal domain and two distinct binding motifs playing key roles in this interaction.
- Immunization with these C3-binding motifs in combination with peptides from another exotoxin, streptolysin S, effectively reduced death rates and skin lesions in mice infected with invasive GAS strains, suggesting a potential subunit vaccine approach against serious GAS infections.
Streptococcal pyrogenic exotoxin B (SPE B), a cysteine protease, is an important virulence factor in group A streptococcal (GAS) infection. SPE B binds and cleaves antibody isotypes and further impairs the immune system by inhibiting complement activation. In this study, we examined the antibody-binding site of SPE B and used it to block SPE B actions during GAS infection.
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