Publications by authors named "Miao-E Liu"
Article Synopsis
- Maternal metabolism issues during pregnancy, like high fat intake, can lead to increased disease risks, such as hypertension, in offspring later in life.
- A study using pregnant rats showed that their high-fat diets resulted in offspring with higher blood pressure and increased leptin levels, even if the offspring's body weight was normal.
- The research also indicated that similar patterns were seen in children, where those born to mothers with high triglyceride levels had elevated blood pressure and leptin, highlighting potential long-term health impacts from maternal hyperlipidemia.
Basonuclin (BNC1) is expressed primarily in proliferative keratinocytes and gametogenic cells. However, its roles in spermatogenesis and testicular aging were not clear. Previously we discovered a heterozygous BNC1 truncation mutation in a premature ovarian insufficiency pedigree.
View Article and Find Full Text PDFArticle Synopsis
- - The study aimed to evaluate the effects of two surgical procedures, great curvature plication with duodenal-jejunal bypass (GCP-DJB) and sleeve gastrectomy (SG), on rats with type 2 diabetes mellitus (T2DM), comparing their impact on weight and glucose metabolism.
- - Rats were divided into three groups: Control, SG, and GCP-DJB, and various metrics like body weight, food intake, blood glucose, and hormone levels were measured pre- and post-surgery over 12 weeks.
- - Results showed that both surgical groups had lower body weight and improved glucose tolerance compared to the Control group, with the GCP-DJB group exhibiting better metabolic parameters than the SG group
Background: Roux-en-Y gastric bypass (RYGB) is effective for the treatment of type 2 diabetes mellitus; however, the mechanism remains unclear.
Methods: The effects of RYGB on postprandial responses to three different diets (low carbohydrate (CH)-rich diet, high CH-rich diet, and fat-rich diet) of different nutritional composition in a Goto-Kakizaki (GK) diabetic rat model were assessed by measuring glucose tolerance, insulin resistance, incretin responses, and bile acid (BA) metabolism.
Results: GK-RYGB group rats lost weight and preferred low CH-rich diet, but there were no significant differences in BW among the different diets.
Objective: The study investigated the use of great curvature plication with duodenal-jejunal bypass (GCP-DJB) in a type 2 diabetic with obesity rat model.
Methods: Twenty-two Sprague-Dawley rats were given a high fat and sugar diet with subsequent intraperitoneal injection of a small dosage of streptozotocin (30 mg/kg) and randomly assigned to either GCP-DJB (n = 12) or Sham surgery (n = 10). Body weight, peripheral blood glucose, and fasting serum insulin were assayed, and insulin resistance index (IRI) was calculated, before and at 1, 2, 4, and 8 weeks after surgery.
Background: Secondary Hyperparathyroidism (SHPT) requiring parathyroidectomy (PTX) occurs more commonly in patients with progressive chronic kidney disease and in those on long-term lithium therapy. Successful PTX often results in a dramatic drop of parathyroid hormone level, relieves the patient from clinical symptoms, and reduces mortality. However, there is an ongoing debate on the optimal surgical treatment of SHPT.
View Article and Find Full Text PDFObjective: This study was intended to demonstrate the feasibility and efficacy of purge parathyroidectomy (PPTX) for patients with secondary hyperparathyroidism (SHPT).
Methods: The "seed, environment, and soil" medical hypothesis was first raised, following review of the literatures, to demonstrate the possible causes of persistence or recurrence of SHPT after parathyroidectomy. Subsequently, the novel surgical strategy of PPTX was proposed, which involves comprehensive resection of the fibro-fatty tissues, including visible or invisible parathyroid, within the region surrounded by the thyroid cartilage, bilateral carotid artery sheath, and the brachiocephalic artery.
Article Synopsis
- Excessive androgen exposure in pregnant women is linked to diabetic traits in their children, suggesting a potential epigenetic effect passed from mother to child.
- A study analyzed women with high androgen levels during pregnancy and followed up with their children, finding increased fasting glucose and insulin levels in those offspring.
- Both human and rat models indicated that maternal hyperandrogenism affects the expression of specific genes related to glucose metabolism, which may contribute to the development of diabetes in later life.
Background And Objectives: The aim of this study was to evaluate the efficacy of carbon nanoparticles in identifying lymph nodes and promoting parathyroid gland function recovery after thyroid carcinoma surgery along with central lymph node dissection.
Methods: A total of 231 patients who underwent thyroid carcinoma surgery combined with central lymph node dissection were divided into two groups: the CN group (intraoperative carbon nanoparticles injections) and the control group (no injection). Datas were collected respectively on the pre-operative, 1st, 7th and 30th postoperative days and monthly thereafter.
The effects of diabetes mellitus include long-term damages, dysfunctions, and failures of various organs. An important complication of diabetes is the disturbance in the male reproductive system. Glucose metabolism is an important event in spermatogenesis.
View Article and Find Full Text PDFBackground: The increasing number of babies conceived by in vitro fertilization and embryo transfer (IVF-ET) shifts concern from pregnancy outcomes to long-time health of offspring. Maternal high estradiol (E2) is a major characteristic of IVF-ET and lasts throughout the first trimester of pregnancy. The fetal thyroid develops during this period and may thus be affected by exposure to the supra-physiological E2.
View Article and Find Full Text PDFObjective: To examine epithelial Na(+) channel (ENaC) expression in endometrium of overweight/obese women with polycystic ovary syndrome (PCOS) during the window of implantation, and to explore the mechanism linking leptin-mediated reduction of γ-ENaC to low endometrial receptivity.
Design: Controlled, prospective, clinical, experimental study.
Setting: University-based infertility center.
Context: The cardiovascular dysfunction in children born with assisted reproductive technologies has been of great concern. However, the association of ovarian hyperstimulation syndrome (OHSS), a complication of assisted reproductive technologies, with worse cardiovascular functions and underlying mechanism remains unknown.
Objectives: The objective of the study was to assess the cardiovascular functions of children born to mothers with OHSS and investigate the underlying regulator(s).
Objectives: The purpose of this study is to investigate the impact of the hepatic branch of the vagus and Roux-en-Y gastric bypass (RYGB) on the level of fasting and postprandial serum glucagon-like peptide-1 (GLP-1) in type 2 diabetic mellitus rats.
Methods: Randomized block design, factorial experiment. Forty-five type 2 diabetic rats were divided into four groups: sham operation (S, n = 10) and sham operation with the hepatic branch of the vagotomy (SV, n = 11), Roux-en-Y gastric bypass (RYGB, n = 12) and RYGB without preservation of the vagus (RYGBV, n = 12).
Article Synopsis
- Some children conceived through in vitro fertilization (IVF) show signs of cardiovascular dysfunction, with higher blood pressure compared to those conceived naturally.
- A study identified 47 differentially expressed proteins in the umbilical veins of IVF newborns, suggesting these proteins could be linked to vascular issues and metabolic processes.
- Higher levels of serum estradiol in cord blood from IVF newborns were found to affect the expression of certain proteins, indicating a potential mechanism behind cardiovascular problems in IVF children.
Background: The impact of the hepatic branch of the vagus and Roux-en-Y gastric bypass (RYGB) on the hypoglycemic effect and glucagon-like peptide-1 (GLP-1) in rats with type 2 diabetes mellitus (T2DM) was investigated, and interactions were preliminarily analyzed.
Methods: A total of 45 rats with T2DM were divided into four groups: sham operation (S, n = 10), sham operation with the hepatic branch of the vagus resected (SV, n = 11), RYGB (n = 12), and RYGB without preservation of the vagus (RYGBV, n = 12). Body mass, fasting blood glucose (FBG), fasting serum insulin, and concentrations of fasting serum GLP-1 were examined in the first, second, fourth, and eighth week before and after surgery.