Publications by authors named "Miao Yan Zheng"
Sodium glucose co-transporter 2 (SGLT-2) inhibitors are newly developed but promising medicine for type 2 diabetes. However, patients with a different renal threshold for glucose excretion (RT(G)) may have a different reaction to this medicine. Therefore, the objective of this study was to investigate the characteristics of RT(G) and its impact factors in patients with type 2 diabetes mellitus (T2DM).
View Article and Find Full Text PDFAims: Growing evidences suggest that acute hyperglycemia is strongly related to kidney injury. Our study aimed to investigate the effects of acute hyperglycemia on kidney glomerular and tubular impairment in non-diabetic conscious rats.
Methods: Non-diabetic conscious rats were randomly subjected to 6h of saline (control group) or high glucose (acute hyperglycemia group) infusion.
Article Synopsis
- This study explores how sleep disturbances (dyssomnia) affect blood pressure variability and the function of pancreatic islet cells in individuals with type 2 diabetes.
- Patients were categorized into dyssomnia and non-dyssomnia groups, and various assessments, including blood pressure monitoring and hormone tests, were conducted to analyze differences between the groups.
- Results indicated that those with dyssomnia had higher levels of glucagon and insulin resistance, along with abnormal blood pressure patterns, suggesting that improving sleep quality could enhance islet cell function and stabilize blood pressure.
Background: Treatment with the alpha-glucosidase inhibitor (AGI) acarbose is associated with a significant reduction the risk of cardiovascular events. However, the underlying mechanisms of this effect are unclear. AGIs were recently suggested to participate in stimulating glucagon-like peptide 1 (GLP-1) secretion.
View Article and Find Full Text PDFObjective: To evaluate the inhibitory effect of statins on glucose-stimulated insulin secretion (GSIS) of pancreatic islet in rat and to explore its mechanisms.
Methods: According to the average volume, freshly isolated or 24-hour cultured pancreatic islets were randomly divided into control group (incubated with Kreb-Ringer bicarbonate buffer), the atorvastatin group (incubated with 100 µmol/L atorvastatin), the fluvastatin group (incubated with 100 µmol/L fluvastatin) and the pravastatin group (incubated with 100 µmol/L pravastatin). Stimulated by 2.