Cavity magnon-polariton interface for strong spin-spin coupling.

Strong coupling between single qubits is crucial for quantum information science and quantum computation. However, it is still challenged, especially for single solid-state qubit. Here, we propose a hybrid quantum system, consisting of a coplanar waveguide (CPW) resonator weakly coupled to a single nitrogen-vacancy (NV) spin in diamond and an yttrium-iron-garnet (YIG) nanosphere holding Kerr magnons, to realize strong long-distance spin-spin coupling.

Visible-Light-Induced Sulfonylation Cyclization to Generate Indole-Fused Medium-Sized -Heterocycles in 2-Me-THF.

A novel visible-light-induced sulfonylation cyclization to indole-fused medium-sized -heterocycles was established under room temperature with biomass-derived 2-Me-THF as the solvent. This reaction proceeds in the absence of external photocatalyst, additive, metal salts, and base. Broad substrate scope, good functional group compatibility, and large-scale synthesis and derivatization via iodination, nitration, chlorination, cyanation, and selenylation demonstrate the utility of this protocol.

[Application Status of Machine Learning in Assisted Diagnosis Techniques of Cardiovascular Diseases].

In recent years, cardiovascular disease has become a common disease. With the development of machine learning and big data technologies, the processing ability of electrocardiogram (ECG) signals has been greatly enhanced through new computer technologies, enabling the auxiliary diagnosis technology for cardiovascular disease (CVD) to achieve new improvements. This article discusses the application of machine learning in ECG processing, especially in the auxiliary diagnosis of diseases.

Long-term outcomes of direct total cavopulmonary connection versus extracardiac conduit in Fontan circulation.

Objective: The long-term outcomes of direct total cavopulmonary connection in Fontan circulation have not been reported yet. This study aimed to compare the long-term outcomes of the direct total cavopulmonary connection procedure with the extracardiac conduit procedure in patients undergoing the Fontan.

Methods: From October 2004 to August 2021, 297 patients undergoing the Fontan operation by extracardiac conduit (n = 268) or direct total cavopulmonary connection (n = 29) procedure at our institution were retrospectively reviewed.

Photochemical aerobic sulfonylation-cyclization-selenylation to indole-fused medium-sized N-heterocycles in 2-Me-THF.

Indole-fused medium-sized diazepinones are privileged structural motifs found in many high-value pharmaceuticals. To construct these challenging molecular skeletons, previous methods are mainly achieved by [5+2] annulation strategies with the aid of transition metal (Pd, Rh, Ru) catalyzed oxidative C-H coupling. Herein, we report a novel visible-light-induced sulfonylation-cyclization-selenylation reaction for the rapid construction of highly functionalized indole-fused medium-sized diazepinones with biomass feedstock 2-Me-THF as the medium.

SWOT analysis of the application of three digital media in OLPE physical education teaching: Edmodo, Zoom, and Google Meet.

Digital education emphasizes the use of technology to enhance and transform teaching, promoting the improvement of instructional models. It is poised to become a significant driving force in advancing high-quality educational development. However, numerous practical challenges remain, such as disadvantages of digital technology resources, ethical norms, and professional training.

The antioxidant role of aromatic plant extracts in managing neurodegenerative diseases: A comprehensive review.

Neurodegenerative diseases (NDDs) are a class of cognitive and motor disorders including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), Amyotrophic Lateral Sclerosis (ALS), and others. They are caused by lesions in cells and tissues of the central nervous system, resulting in corresponding dysfunctions and consequent decline in cognitive and motor functions. Neural tissues are extremely vulnerable to oxidative stress, which plays critical biological roles in NDDs.

Tac1-expressing neurons in the central amygdala predominantly mediate histamine-induced itch by receiving inputs from parabrachial Tac1-expressing neurons.

Itch is a distinct and bothersome sensation closely associated with a strong urge to scratch. Both the parabrachial nucleus (PBN) and the central amygdala (CeA) are responsive to itch stimuli and contain neurons that express tachykinin 1 (Tac1), which are known for their significant involvement in itch-induced scratching at both spinal and supraspinal levels. Significantly, the PBN neurons project their axons to form close connections with the CeA neurons.

Development of phase-change protective clothing for improving safety of firefighters in low thermal radiation.

To enhance firefighters' safety in fire environments, new phase-change protective clothing was developed using a drip molding process to improve thermal protection and thermal comfort. The effects of the droplet interval (1, 1.5 and 2 cm) and droplet diameter (4, 6 and 8 mm) on the thermal protective performance under low thermal radiation were examined by the stored energy tester (SET).

Gene-knockdown Methods for Silencing Nuclear-localized Insulin Receptors in Lung Adenocarcinoma Cells: A Bioinformatics Approach.

Background: Lung adenocarcinoma, the predominant subtype of lung cancer, presents a significant challenge to public health due to its notably low five-year survival rate. Recent epidemiological data highlights a concerning trend: patients with pulmonary adenocarcinoma and comorbid diabetes exhibit substantially elevated mortality rates compared to those without diabetes, suggesting a potential link between hyperinsulinemia in diabetic individuals and accelerated progression of pulmonary adenocarcinoma. Insulin Receptor (IR) is a tyrosine-protein kinase on the cell surface, and its over-expression is considered the pathological hallmark of hyperinsulinemia in various cancer cell types.

Divergent Synthesis of Polysubstituted 1,2-Dihydropyridines and Pyridines through Manganese-Mediated Radical Cascade Cyclization of Tertiary Enamides.

A Mn(III)-mediated radical cascade cyclization of -propargyl enamides with sodium sulfinates was developed. Mechanistic studies indicated that this cascade process is mainly composed of the chemoselective addition of sulfonyl radical to C≡C bond and the regioselective intramolecular 6--trig cyclization. This protocol provided a powerful method for the divergent synthesis of diverse polysubstituted -sulfonylpyridines or 1,2-dihydropyridines just by varying solvent and temperature featuring good functional group compatibility and simple operation.

Circulating inflammatory cytokines and colorectal cancer: New insights from Mendelian randomization.

Colorectal cancer (CRC) is one of the most common cancers worldwide and inflammation is believed to play an important role in CRC. In this study, we comprehensively analyzed the causal association between 91 circulating inflammatory cytokines and the risk of CRC using Mendelian randomization (MR). Based on genome-wide association study summary statistics, we examined the causal effects of 91 circulating inflammatory cytokines on CRC.

ds-FCRN: three-dimensional dual-stream fully convolutional residual networks and transformer-based global-local feature learning for brain age prediction.

The brain undergoes atrophy and cognitive decline with advancing age. The utilization of brain age prediction represents a pioneering methodology in the examination of brain aging. This study aims to develop a deep learning model with high predictive accuracy and interpretability for brain age prediction tasks.

Nlnemo suppresses of BMP signaling in wing development of the brown planthopper, Nilaparvata lugens.

Nemo-like kinases (NLKs) integrate multiple signaling pathways and exhibit functional diversity in developmental processes, including the bone morphogenetic protein (BMP) pathway. However, their roles in insect wing development, particularly in hemimetabolous insects like the brown planthopper (Nilaparvata lugens), remain poorly understood. Here, we investigated the role of Nlnemo (Nlnmo), an NLK, in the wing development of N.

The dual effects of the air gap on thermal aging and thermal protection of firefighting suits exposed to wildland fires.

In wildland firefighting, the air gap (AG) between clothing and the human body can effectively decrease heat transferred to skin but has a negative impact on thermal aging of clothing. Heat transfer to skin from a fire source can led to burn injuries and heat is transmitted between adjacent AGs parallel to the skin surface. An open AG simulator was developed to explore the dual effects of the AG on fabric thermal aging and skin thermal protection.

Iron(III)-Mediated Nucleophilic Cascade Cyclization of Tertiary Enamides with Diselenides for the Construction of 3-Seleno-2-pyridones.

An iron(III)-mediated nucleophilic cascade cyclization of -propiolyl enamides with various diselenides was developed, which provides an efficient way to construct seleno-heterocycles. A mechanism study shows that the cascade process involves the selective addition of diselenides to the C≡C bond generating a seleniranium ion, followed by an intramolecular nucleophilic attack of enaminic carbon of tertiary enamide. Utilizing this protocol, a variety of 3-seleno-2-pyridones were successfully synthesized featuring good functional group compatibility and simple operation.

PB2 627V and HA 217 sites synergistically affect the lethality of H9N2 in mice.

The H9N2 subtype avian influenza virus (AIV) continues to propagate and undergo evolution within China, thereby posing a significant threat to the poultry industry. This study encompassed the collection of 436 samples and swabs in East China over the period spanning 2018 to 2019, from which 31 strains of the H9N2 subtype viruses were isolated and purified. We revealed that the HA and NA genes of the 31 isolates categorized within the Y280 branch, while the PB2 and M genes were associated with the G1 branch, and the remaining genes aligned with the F/98 branch.

Decoding continuous motion trajectories of upper limb from EEG signals based on feature selection and nonlinear methods.

Brain-computer interface (BCI) system has emerged as a promising technology that provides direct communication and control between the human brain and external devices. Among the various applications of BCI, limb motion decoding has gained significant attention due to its potential for patients with motor impairment to regain independence and improve their quality of life. However, the reconstruction of continuous motion trajectories in BCI systems based on electroencephalography (EEG) signals remains a challenge in practical life.

BACE1 inhibition via miR-6838-5p overexpression inhibits insulin resistance and the immune response in HFD-induced obesity in mice model.

Context: Obesity is a chronic inflammatory disorder, which promotes the progression of metabolic disorders. MicroRNA (miR)-6838-5p is dysregulated and participates in the progression of several disorder models.

Objective: To explore the role and mechanism of miR-6838-5p in insulin resistance.

Engineering Heterointerface to Synergistically Regulate Kinetics and Stress of Copper-Cobalt Selenide toward Reversible Magnesium/Lithium Hybrid Batteries.

Metal chalcogenide-based cathodes are crucial for the development of rechargeable magnesium batteries, yet the strong electrostatic interactions of Mg result in slow ion transport and high polarization. The Mg/Li hybrid battery holds promise for enhancing the energy storage capability. Herein, we establish a system that utilizes (Co,Cu)Se/CoSe heterostructure grown on carbon cloth as the cathode and APC-LiCl as a dual-salt electrolyte to achieve high reversible capacity, enhanced cyclic stability, and impressive rate performance.

Purtscher-like retinopathy and paracentral acute middle maculopathy associated with improper antihypertensive drug use: a case report.

Background: Purtscher-like retinopathy (PLR) is a rare retinal microangiopathy with unclear pathogenesis. Paracentral acute middle maculopathy (PAMM) is an optical coherence tomography (OCT) sign proposed in recent years, which is characterized by infarction of the middle layer of the retina. This article reported a rare case of PRL and PAMM probably related to improper antihypertensive drug use in a middle-aged male.

α-Ketoglutarate promotes cardiomyocyte proliferation and heart regeneration after myocardial infarction.

The neonatal mammalian heart can regenerate following injury through cardiomyocyte proliferation but loses this potential by postnatal day 7. Stimulating adult cardiomyocytes to reenter the cell cycle remains unclear. Here we show that cardiomyocyte proliferation depends on its metabolic state.

Core-shell structured MgCoO@Ni(OH) nanorods as electrode materials for high-performance asymmetric supercapacitors.

In the field of energy storage, supercapacitors have received extensive attention in recent years. However, achieving the expected electrochemical performance and energy density of supercapacitors is still a huge challenge. The design and synthesis of binder-free composite electrode with core-shell structure is an effective strategy to improve the electrochemical performance of supercapacitors.