Publications by authors named "Miao Deng"

Background: Chronic kidney disease (CKD) is a global health challenge with diverse etiologies. However, research on the incidence trends of CKD attributable to specific causes remains limited, and the incidence and mortality rates vary across regions. This study aims to identify the patterns and temporal trends of CKD incidence, providing valuable information for the development of targeted prevention strategies and interventions.

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Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by Dabie bandavirus (DBV). We report a case of DBV and Mycoplasma pneumoniae (MP) co-infection.

Case Presentation: Here we reported a 57-year-old healthy male who was admitted with the presentations of fever, cough, hemoptysis, and hypotension.

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Article Synopsis
  • The study aimed to compare the effectiveness of weekly nab-paclitaxel versus the standard treatment of docetaxel plus carboplatin, both combined with trastuzumab and pertuzumab, for patients with HER2-positive early-stage breast cancer.
  • HELEN-006 was a phase 3 trial conducted across six hospitals in China, enrolling 689 patients with untreated, confirmed stage II-III HER2-positive breast cancer, who were randomly assigned to one of the two treatment groups.
  • The trial's final analysis focused on the primary endpoint of pathological complete response, with ongoing follow-up for the adjuvant phase, and the trial is registered under ClinicalTrials.gov (NCT04547907).
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Objective: To explore the relationship between hypertensive comorbidity patterns and social participation and depressive symptoms in middle-aged and elderly hypertensive patients.

Methods: Using the data from the 2015, 2018 and 2020 of the China Health and Retirement Longitudinal Study, 2786 middle and elderly adults aged 45 and above with hypertension were included. Data analysis was performed in Stata 17.

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Oral lichen planus (OLP) is a chronic inflammatory disease that is associated with an increased risk of carcinogenesis. The typical pathological features of OLP include submucosal T-cell banding, infiltration, and liquefactive degeneration of basal epithelial cells. However, the histological appearance of basal cell death cannot be explained by apoptosis of keratinocytes alone.

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  • The study examined the use of magnesium oxysulfate cement (MOS) as a binder for improving the properties of loess soil, focusing on changes in density, porosity, and structure.
  • Results showed that the addition of 13% MOS significantly reduced porosity from 40.97% to 28.75% and enhanced compressive strength to 7.9 MPa after 28 days of curing.
  • Additionally, the MOS-stabilized loess demonstrated good durability, maintaining a softening coefficient of 0.66 after water immersion and a minimal compressive strength change of 6.3% after five freeze-thaw cycles, indicating its effectiveness for soil stabilization.
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Oxidative stress and inflammation are key drivers of osteoarthritis (OA) pathogenesis and disease progression. Herein we report the synthesis of poly(-coumaric) nanoparticles (PCA NPs) from -courmaic acid (-CA), a naturally occurring phytophenolic acid, to be a multifunctional and drug-free therapeutic for temporomandibular joint osteoarthritis (TMJOA). Compared to hyaluronic acid (HA) that is clinically given as viscosupplementation, PCA NPs exhibited long-term efficacy, superior anti-oxidant and anti-inflammatory properties in alleviating TMJOA and repairing the TMJ cartilage and subchondral bone in a rat model of TMJOA.

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  • Male breast cancer incidence is rising, and this study aimed to evaluate long-term survival outcomes using a conditional survival approach to guide clinical decisions.
  • An analysis of 3,600 male breast cancer patients revealed that the 5-year real-time survival rate significantly improved over time, indicating better prognoses for those diagnosed.
  • Key factors affecting prognosis over 5 years included age, tumor size, and stage at diagnosis, leading to the development of a conditional survival nomogram to assist in predicting 10-year survival rates.
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Objectives: The aim of this study was to investigate the dynamic longitudinal relationship between grip strength and cognitive function.

Methods: 6175 participants aged ≥50 years were included in the study using three waves of follow-up data from the Survey of Health, Ageing, and Retirement in Europe in 2015 (T1), 2017 (T2) and 2019 (T3). Cognitive function was assessed using numeracy, verbal fluency, immediate recall, delayed recall and total.

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Identifying biomarkers with high sensitivity and stability is helpful for the timely and accurate diagnosis, and effective management of polycystic ovary syndrome (PCOS), a long-term, progressive endocrine disorder. Circulating microRNAs (miRNAs/miRs) are being increasingly recognized as promising biomarkers given the stability and enrichment of miRNAs in exosomes. The high sensitivity of the reverse transcription-quantitative PCR (RT-qPCR) has enabled accurate quantification of miRNAs and small fragments, present in a low abundance, in the circulation.

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Purpose: Different arch structures may cause different foot function injuries. In the past, the arch structure and flexibility of the foot were often defined by the height of the arch, and there was no three-dimensional (3D) structure classification method. In order to form a more complete 3D description, we propose a new classification system of arch volume flexibility (AVF), and then use this new classification system to investigate the relationship between the AVF and arch index (AI), and the arch height flexibility (AHF) and AI, respectively.

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  • The paper in question was retracted due to concerns that some of its data, specifically the GAPDH control western blotting results, closely resembled data from a different study by unrelated authors.
  • Additionally, similar results from cell-cycle experiments in the paper raised further suspicions regarding the validity of the research.
  • The Editor made the decision to retract the paper after not receiving an explanation from the authors, and expressed regret for any inconvenience this situation may have caused to readers.
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Tumor-derived exosomes (TDEs) carry various biomolecular cargos and play crucial roles in metastasis. TDEs migrate to distal organs for intercellular communication and induce the formation of pre-metastatic niches (PMNs) to support tumor implantation and proliferation. Precise interference in the bioprocess of TDEs is expected to be efficacious for suppressing tumor metastasis.

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Background: The value of human leukocyte antigen (HLA; also known as major histocompatibility complex) class I expression for the prediction of breast cancer survival outcomes remains unclear. We conducted a meta-analysis to explore the prognostic significance of this expression.

Materials And Methods: We searched electronic databases to identify reports on associations of HLA class I protein or mRNA expression with survival outcomes and clinicopathological factors in the breast cancer context.

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Gene mutations play an important role in head and neck squamous cell carcinoma (HNSCC) by not only promoting the occurrence and progression of HNSCC but also affecting sensitivity to treatment and prognosis. KRAS is one of the most frequently mutated oncogenes, which has been reported to have a mutation rate from 1.7% to 12.

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Blood and lymph are two main pathways of tumor metastasis; however, hematogenous metastasis and lymphatic metastasis are difficult to inhibit simultaneously. Ferroptosis provides a new breakthrough for metastasis inhibition, but how to effectively trigger ferroptosis in tumor cells remains a major challenge. Metastatic tumor cells are prone to ferroptosis in blood, while they may be protected from ferroptosis in lymph.

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Background: The development of novel human epidermal growth factor receptor 2 (HER2) antibody drug conjugates brings encouraging opportunities for the treatment of HER2-low breast cancer. In this study, we investigated the clinical factors and prognosis of HER2-low breast cancer after neoadjuvant chemotherapy (NAC).

Methods: Data from patients diagnosed with HER2-zero or HER2-low breast cancer at a single center between January 2017 and December 2021 who underwent NAC followed by surgery were retrospectively reviewed.

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Objective: The aim of this research was to determine whether systemic inflammatory indicators, including aggregate index of systemic inflammation (AISI), neutrophils lymphocyte to platelet ratio (NLPR), systemic immune-inflammation index (SII), and systemic inflammation response index (SIRI), are related to bone mineral density (BMD) in perimenopausal and postmenopausal women.

Methods: One hundred and eighty-one perimenopausal and 390 postmenopausal women were enrolled in this cross-sectional study. Continuous variables by analysis of variance and Kruskal Wallis test for comparing the clinical characteristics.

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To explore the pharmacological basis and mechanism of Buxue Yimu pills (BYP) in the treatment of anaemia in women from the perspective of metabolomics and network analysis. Forty-six women of reproductive age with haemoglobin 70-110 g/L were recruited. Blood samples were collected before and after 4 weeks of oral BYP treatment to assess the changes in haemoglobin, coagulation function, and iron metabolism indices.

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Background: Insulin-like peptide 5 (INSL5) is involved in both reproductive and metabolic processes in polycystic ovary syndrome (PCOS). This study aimed to evaluate the relationship between INSL5 and anti-Müllerian hormone (AMH).

Methods: A retrospective case-control study was conducted in a university-based reproductive centre between December 2019 and January 2021.

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Article Synopsis
  • - Polycystic ovary syndrome (PCOS) is a common cause of infertility in women due to issues with ovulation, and some women with high levels of luteinizing hormone (LH) face poor ovarian response during fertility treatments.
  • - A 28-year-old woman with PCOS and high basal LH underwent IVF but had to cancel treatment due to poor ovarian response, but later successfully developed follicles with a milder treatment protocol combining clomiphene citrate (CC) and gonadotropins.
  • - The use of the CC protocol was effective as it maintained elevated LH levels, resulting in better follicular development and higher-quality embryos, suggesting that women with PCOS and poor ovarian response may need higher LH for
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Baroni [Asphodelaceae], which is traditional herbal medicine, has been widely used for treating depressive disorders in Eastern-Asia countries. However, the active compounds and corresponding mechanism of anti-depression are not yet completely clarified. In this study, the anti-depressive activities of six extracts were primarily evaluated.

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