Publications by authors named "Mianling Mo"
Front Pharmacol
November 2023
Article Synopsis
- - Slow transit constipation (STC) is linked to changes in gut bacteria and fewer enterochromaffin cells (ECs), and Astragaloside IV (AS-IV) appears to improve STC symptoms, though its exact mechanisms are still unclear.
- - In a study using mice with STC induced by loperamide, AS-IV treatment increased defecation frequency, enhanced intestinal mobility, reduced EC loss, and improved colonic health while also affecting gut microbiota and metabolites like 3-bromotyrosine (3-BrY).
- - The research suggests that AS-IV's benefits for STC may involve changes in gut bacteria and EC protection, with 3-BrY potentially playing a role in preventing cell death by mod
