Publications by authors named "Mian-Dong Zeng"
Background: Hemophilia A is a rare inherited bleeding disorder caused by mutations in the factor VIII gene. This clotting factor plays an intrinsic role in the blood coagulation pathway. Patients with hemophilia may develop orthopedic manifestations such as hemarthrosis, but multiple malunion of fractures over the knee is rare and difficult to treat.
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- The study examined how long-term glucocorticoid (GC) treatment affects the structure of two types of bone in the femoral head of sheep.
- Eighteen female sheep were divided into three groups: one received GC treatment for 7 months, one received the same treatment followed by 3 months without it, and a control group had no treatment.
- Results showed that GC treatment significantly harmed the cancellous bone structure but had little effect on cortical bone; many cancellous bone properties recovered after the treatment stopped, whereas cortical thickness remained unchanged.