Revealing Lingonberry's Neuroprotective Potential in Alzheimer's Disease Through Network Pharmacology and Molecular Docking.

Alzheimer's disease is a progressive neurodegenerative disorder with limited treatment options. Lingonberry ( L.) has demonstrated neuroprotective and anti-inflammatory properties, yet the underlying mechanisms remain unclear.

Development and validation of a nomogram for predicting the outcome of metabolic syndrome among people living with HIV after antiretroviral therapy in China.

Background: The prevalence of metabolic syndrome among people living with HIV (PLWH) is increasing worldwide. This study aimed to develop and validate a nomogram to predict the risk of metabolic syndrome in PLWH receiving antiretroviral therapy (ART) in China, accounting for both traditional and HIV-specific risk factors.

Methods: A retrospective cohort study was conducted among PLWH receiving ART at a designated treatment center in Yinzhou District, China.

Long Term Outcomes of Endovascular Treatment for Retrograde Ascending Aortic Dissection.

Objective: The optimal treatment for retrograde ascending aortic dissection (rAAD) remains unclear. In this study, the long term clinical outcomes of endovascular treatment for rAAD were retrospectively investigated, and haemodynamic remodelling of the ascending aorta was analysed.

Methods: This retrospective, single centre study analysed clinical data of rAAD cases treated with endovascular therapy from 2001 - 2020.

The regulation of UV-B - Triggered ABA signal on isoflavones synthesis in soybean suspension cells.

Isoflavones are abundant antioxidant components in soybeans. UV-B radiation can induce the biosynthesis of isoflavones in soybean suspension cells, but the underlying molecular mechanism remains unclear. The transcriptome analysis revealed that UV-B radiation influenced the biosynthesis and signal transduction of the phytohormone abscisic acid (ABA) during the biosynthesis of isoflavones in soybean suspension cells.

Biologically active filtration (BAF) for metabolic 1,4-dioxane removal from contaminated groundwater.

1,4-Dioxane is a persistent contaminant that is not effectively removed by conventional water treatment processes. In this study, bench-scale granular activated carbon (GAC)-based biologically active filtration (BAF) systems were developed to metabolically degrade 1,4-dioxane at environmentally relevant levels (<1000 μg L). BAF was established using predeveloped biologically activated carbon particles by mixing a 1,4-dioxane-degrading microbial community with granular activated carbon.

An entomopathogenic strain of (hypocreales: Cordycipitaceae) against (acarina: Tetranychidae) and its compatibility with (acarina: Phytoseiidae).

is an important pest on several agricultural crops, and its resistance to pesticides has promoted the exploration of biological control strategies. and have been identified as potential agents for suppressing spider mites. This study aimed to investigate the pathogenicity of on and its compatibility with .

A near-infrared fluorescent probe toward β-Gal with dual-targeting potential of hepatocytes and lysosomes: Design, synthesis, and evaluation.

In this work, a novel near-infrared fluorescent probe of benzopyranonitrile toward β-Gal was developed with high selectivity and low detection limits. DCM-Mor-Gal could effectively distinguish hepatocellular cells (HepG2) from SGC7901, HeLa, A549, and human normal liver cells (HL-7702) under the mediation of the galactose group, and effectively aggregate in the lysosomes under the acidity-alkalinity attraction, showing a notable dual-targeting potential of hepatocytes and lysosomes. The zebrafish experiments confirmed the utility of DCM-Mor-Gal in detecting β-Gal in vivo, which is expected to be an effective tool for the clinical detection of related diseases.

Pathway linking nutritional status to cognitive function in older adults with chronic diseases: Exploring the mediating role of sleep quality.

Objective: This study aimed to explore the pathway linking nutritional status to cognitive function in older adults with chronic diseases, and whether sleep quality potentially mediates their association.

Methods: A cross-sectional study was conducted among 248 older adults with chronic diseases who were admitted in a district tertiary hospital, Shenzhen, China from January to December 2022. The participants completed the sociodemographic and clinical characteristics questionnaire, the Mini Nutritional Assessment Short Form (MNA-SF), the Montreal Cognitive Assessment (MoCA), and the Pittsburgh Sleep Quality Scale (PSQI).

Comparative study of clinical efficacy of laparoscopic proximal gastrectomy with double-channel anastomosis and tubular gastroesophageal anastomosis.

Background: According to statistics, the incidence of proximal gastric cancer has gradually increased in recent years, posing a serious threat to human health. Tubular gastroesophageal anastomosis and double-channel anastomosis are two relatively mature anti-reflux procedures. A comparison of these two surgical procedures, tubular gastroesophageal anastomosis and double-channel anastomosis, has rarely been reported.

Plasma metabolomic signature of a proinflammatory diet in relation to breast cancer risk: a prospective cohort study.

Background: A proinflammatory diet has been linked to an increased risk of breast cancer. However, the underlying metabolic roles remain to be elucidated.

Objectives: This study aimed to investigate the metabolic mechanism between proinflammatory diet and breast cancer risk.

Photodynamic bactericidal nanomaterials in food packaging: From principle to application.

Compared to traditional preservatives, photodynamic inactivation (PDI) offers a promising bactericidal approach due to its nontoxic nature and low propensity for microbial resistance. In this paper, we initially investigate the principles and antibacterial mechanisms underlying PDI. We then review factors influencing PDI's germicidal efficacy in food preservation.

Safety and efficacy of chocolate balloon in the treatment of infrapopliteal artery disease.

Objective: To evaluate the safety and efficacy of chocolate balloons in patients with chronic limb-threatening ischemia (CLTI) and infrapopliteal artery disease, and compare them with conventional balloons.

Methods: This single-center retrospective study included 167 patients with CLTI and infrapopliteal who underwent endovascular intervention with or without chocolate balloons from September 1, 2019 to June 30, 2023. The primary endpoint was amputation-free survival (AFS).

Functional characterization and regulatory pattern of Neoseiulus barkeri peptidoglycan recognition protein (PGRP).

Compared with traditional biological control, the co-use of entomopathogenic fungi and multiple enemies has made great progress in biocontrol technology. However, the risk posed by entomopathogenic fungi to their host has not been fully evaluated. Further, the interaction between them has not described adequately.

Drug-Coated Balloon Treatment for LAD CTO in a Young Woman With Moyamoya Disease Guided by Intravascular Imaging.

Moyamoya disease (MMD) is a rare, progressive steno-occlusive disease of the intracranial carotid arteries. Coronary artery disease associated with MMD has been described in several cases. Coronary artery bypass grafting and percutaneous coronary intervention (PCI) with stent implantation were performed mainly for MMD patients with myocardial ischemia caused by coronary stenotic lesions.

The effect of vitamin D supplementation on antibiotic use: a meta-analysis based on randomized controlled trials.

Objective: This meta-analysis explores the impact of vitamin D supplementation on antibiotic utilization.

Methods: We systematically searched for relevant randomized controlled trials (RCTs) in PubMed, Web of Science, EMBASE, and Science Direct from inception to April 2024. These trials compared antibiotic use rates between groups receiving vitamin D supplements and placebo.

Neutral Interface Directed 3D Confined Self-Assembly of Block Copolymer: Anisotropic Patterned Particles with Ordered Structures.

Three-dimensional confined self-assembly (3D-CSA) of block copolymers (BCPs) is a distinctive and robust strategy that can yield colloidal polymer particles boasting ordered internal structures and diverse morphologies. The unique advantage of neutral interface lies in its ability to create anisotropic particles with surface patterns. The resulting unique polymer particles exhibit deformability under swelling, coupled with excellent spreadability and optical properties.

[Effect of dual-wavelength laser combined with bioceramics iRoot SP to assist molar root canal treatment].

Purpose: To investigate the effect of dual-wavelength laser combined with bioceramics material iRoot SP on molar root canal treatment.

Methods: A total of 104 patients receiving root canal treatment from January 2020 to June 2023 were selected and divided into control group and experimental group according to random number table method, with 52 cases in each group. The control group was treated with iRoot SP paste, and the experimental group was treated with dual-wavelength laser(Nd:YAG and Er:YAG) combined with iRoot SP paste.

Greenhouse gas emission and denitrification kinetics of woodchip bioreactors treating onsite wastewater.

The accurate evaluation of denitrification rate and greenhouse gas (GHG) emission in field-scale woodchip bioreactors for onsite wastewater treatment are problematic due to inevitably varied environmental conditions and underestimated GHG production with limited analysis of dissolved gas in field samples. To address these problems, batch incubation experiments were conducted with controlled conditions to precisely evaluate the denitrification kinetics and NO and CH emission of both gaseous and dissolved phases in fresh (6 months) and aged (5 years) woodchip bioreactors treating onsite wastewater at high (1-3 mg L) and no (0 mg L) dissolved oxygen (DO) levels. NO removal rate decreased from 37.

MEK inhibitor trametinib combined with PI3K/mTOR inhibitor BEZ-235 as an effective strategy against NSCLC through impairment of glucose metabolism.

The MAPK and PI3K/AKT/mTOR pathways are aberrantly activated in non-small cell lung cancer (NSCLC) patients, but therapeutic efficacy of NSCLC using trametinib (MEK inhibitor) or BEZ-235 (dual PI3K/mTOR inhibitor) alone is still unsatisfactory. Therefore, in this study, we aimed to determine whether the combination of trametinib with BEZ-235 exerted synergistic effects against NSCLC in both in vitro and in vivo models, and we preliminarily explored the effect of this combination therapy on glucose metabolism. Our results showed that trametinib combined with BEZ-235 could better inhibit cell proliferation and colony formation, induce G0/G1 phase arrest and apoptosis, and suppress cell invasion and migration compared with the single agent.