Effect of methylphenidate on mismatched visual information processing in young healthy volunteers: an event-related potential study.

This study was to investigate whether a single dose of methylphenidate (MPH), a dopamine and noradrenaline enhancing drug for the treatment of attentional deficits, influences mismatch visual information processing in young healthy volunteers determined with N270. A randomized double-blinded placebo-controlled study was conducted, and each participant was tested on two sessions separated by two weeks. On each session, a matching task was given first, followed by taking an opaque capsule (20 mg MPH or placebo), and matching task was administered again after 90-min rest.