A New Polycyclic Polyprenylated Acylphloroglucinol Derivative from Garcinia verrucosa.

In our continuing phytochemical screening program aimed at finding major constituents. of endemic Madagascar plants as potential templates for semisynthesis, we investigated the ethyl acetate extract of stem bark of Garcinia verrucosa. Fractionation of the extract led to the isolation of the major compound named garcicosin.

Cytotoxic 3,4-seco-Atisane Diterpenoids from Croton barorum and Croton goudotii.

In a screening program directed to the discovery of new anticancer agents from Madagascan plants, ethyl acetate extracts of Croton barorum and C. goudotii showed strong cytotoxic activity, with 100% inhibition at 10 μg/mL in a primary screen using the murine lymphocytic leukemia P388 cell line. Bioassay-guided fractionation led to the isolation of two new 3,4-seco-atisane diterpenoids, crotobarin (1) and crotogoudin (2).