Identification of hypometabolic areas in the brain using brain imaging and hyperbaric oxygen.

Current neurologic assessments consider idling neurons and ischemic penumbras to be metabolically lethargic and electrically nonfunctional or nonviable. Diagnosis, prognosis, and therapeutics of central nervous system dysfunctions require differentiation between viable and nonviable neurons. It is necessary to develop and document efficacious and safe techniques for reactivating idling neurons.

Enhanced diagnosis of hand and wrist disorders by triple phase radionuclide bone imaging.

Triple phase radionuclide bone imaging (TPI), a diagnostic study, consists of a blood flow evaluation by means of an intravenous bolus injection of radionuclide tracer and rapid sequential images which show the arterial pattern; an immediate static image reflecting the pooling of activity in the soft tissues; and delayed static images taken about one hour later which reflect bone localization of the radiotracer. TPI is not specific for a particular condition, but it will confirm or rule out the presence of disease.

[67Ga]citrate scintiscanning in active inflammatory bowel disease.

Twenty-five hospitalized patients were studied prospectively with [67Ga]citrate (GA) abdominal scintillation scanning in an attempt to define its role in the evaluation of patients with active inflammatory bowel disease (IBD). There were nine patients with ulcerative colitis (UC), seven with Crohn's disease (CD), and nine controls. In four patients, two with UC and two with CD, a tissue/plasma radioactivity ratio was obtained and compared to normals.

Computerized tomography, diagnostic ultrasound, and radionuclide scanning. Comparison of efficacy in diagnosis of pancreatic carcinoma.

Forty-six patients, including 33 with proved pancreatic carcinoma, were studied with computerized tomography (CT), ultrasound (US), and radionuclide (RN) scanning. The results of each scanning procedure were compared with the surgical and clinical findings. The detection rate was 82% for CT, and 92% with US.

A new dual-probe system for the rapid bedside assessment of left ventricular function.

A mobile dual-probe system has been developed for the rapid bedside measurement of left ventricular ejection fraction (LVEF) from the beat-to-beat count rate variations that occur during the transit of a single radionuclide bolus through the left ventricle (LV). Cardiac output, pulmonary blood volume, and left ventricular end-diastolic volume can also be calculated. The dual-probe system incorporates a central collimated probe for monitoring activity in the LV surrounded by an annular detector collimated in such a manner as to provide simultaneous real-time monitoring of the LV background activity.

Applications of diagnostic ultrasound and radionuclides to cardiovascular diagnosis. Part II. Cardiovascular disease in the young.

Echocardiography (ECHO) and radionuclide cardiography have had a significant impact on pediatric cardiology because they have proved to be sensitive enough to permit early diagnosis of many forms of heart disease and in some cases to estimate its severity and to provide information concerning ventricular performance. An overview of the anatomic and functional information that can be obtained from these two methods will be presented first, followed by details concerning the indications for their use and their relative clinical value in various acquired and congenital heart diseases. We have stressed particularly those facets of pediatric cardiac disease that differ most from those in the adult.

Applications of diagnostic ultrasound and radionuclides to cardiovascular diagnosis. Part I. Acquired cardiovascular disease in the adult.

Noninvasive methods have become an important part of the diagnostic process for evaluation of cardiovascular anatomy and function in adults and in the young. Because there is a multiplicity of noninvasive methods presently available, in some cases with overlapping capabilities, there has been some confusion as to which constitutes the method of choice in a given clinical circumstance. The reviews that follow outline some of the practical strengths and limitations of two methods (echocardiography and radionuclide cardiography), hopefully thereby providing some rationale for choosing the more appropriate technique in the approach to specific clinical problems.