[The results of the multicenter pharmaco-epidemiological observational project on the use of mydocalm in the treatment of pain syndromes with the muscle spasm].

The prospective multicenter open noncomparative pharmaco-epidemiological observational project on the use of mydocalm in real clinical practice has been completed in 2013. The project has been performed in 2090 clinical/rehabilitation settings in 284 cities of 13 countries using the results of 35,383 patients. The project aimed to assess the safety of treatment (percentage of patients with adverse-effects) and pain relieving efficacy as well as patient's satisfaction with the treatment.

[Medical, psychological, social and gender aspects of aging in modern Russia].

In this article, the authors considered controversial issues ambiguous attitude to the aging process of the population of the Russian Federation on the basis of a number of individual differences--psychological, social, sexual, and medical. The thesis is that, unfortunately, the fight against aging appears rather to be more a struggle with an already existing old age, and you need to develop preventive measures against aging much earlier than is currently done. Submissions own research confirm this position.

[Comparative biochemistry of process of ageing in men and women].

In the research of a number of biochemical indicators in 858 men and 899 women aged from 20 till 70 years divided into 6 compared groups depending on age and gender clear distinctions in the dynamics of the components of the lipid status, status of lipid peroxidation and antioxidant activity of the blood system, the content of middlemolecular peptides are revealed. Simultaneous determination of the biological age of the subjects also revealed a distinct gender differencies testifying to lower rate of aging of men, despite the probability of earlier, in comparison with women, development of dislipidemia and atherosclerosis. Association of the received gender distinctions both with changes of level of estrogen in women due to menopause and with the peculiarities of stressful impacts on male and female organism in different age periods is supposed.

[Depressive disorders in elderly and senile patients in the period of rehabilitation after acute ischemic stroke].

To definite the probability of occurrence of depression after suffering an ischemic stroke in elderly and senile age and the impact of depressive disorders on the results of the rehabilitation treatment the comparative study of 186 patients aged over 70 and 110 patients at the age of 33-60 years was carried out. The results testify that the frequency of occurrence and severity of post-stroke depression do not depend on age. But the depression has a more significant impact on the results of the rehabilitation treatment in the elderly than in patients of the young and middle age, which is explained by a long existence in the period prior to the stroke of the emotional-volitional disorders, characteristic for the elderly and senile age.

[Treatment of elderly and senile patients suffering from benign prostatic hyperplasia and chronic prostatitis].

In the clinical settings and in animal experiments the research was conducted on effectiveness and safety of treatment the benign prostatic hyperplasia, chronic prostatitis in the stage of active inflammation in elderly and senile patients. The method of treatment including transrectal fonoforez of the Russian preparation of Tisol (Tisolium, gel, the company "Olympus" Yekaterinburg) in combination with diclofenac sodium protected by patents of the Russian Federation was used. The developed method of treatment has shown high efficiency and safety, which is confirmed by experimental, clinical, laboratory and instrumental studies.

[Age-related aspects of the extent of lipid metabolism and post-traumatic stress disorders among veterans of modern warfare].

The peculiarities of violations of lipid metabolism and symptoms of post-traumatic stress disorder (PTSD) in 161 patients of 25-69 years, veterans of the military actions on the territory of Afghanistan and the Northern Caucasus were investigated. The dependence of the formation of dyslipidemia and related changes of atherosclerosis in the young age on neuroendocrine effects, accompanying the effects of combat stress and promoting accelerated aging was determined. On the other hand, with the time, after 15-25 years after participating in hostilities, the intensity of PTSD and its influence on the development of violations of lipid spectrum may decline.

[Some problems of modern gerontology and geriatrics in the Russian Federation: the sight of the clinical physician].

This article presents some problems of modern Russian gerontology and geriatrics by eyes of the scientist--the clinical physician having long-term experience in the field. Educational, scientific, practical aspects of gerontology and those stereotypes of understanding of problems of elderly which developed for years are subjected the certain criticism, decades, but in the modern world any more absolutely correspond to a today's reality. It is offered to transform the ideology of the major directions of gerontology, having put at the head of a corner not ideas of prolongation of life as that and carrying out basically actions in relation to seriously ill, but improvements of quality of life, preventive maintenance and treatment of set of the age-related diseases, overcoming of the developed practice of the relation to elderly and senile patients as to persons dependent and demanding the constant help.

[Age-specific dynamics of mental working capacity in different regimens of locomotor activity].

The present study included a total of 392 practically healthy men aged between 40 and 79 years differing in the character of routine locomotor activity and the training status (from masters of sport of international grade to the subjects who had never been engaged in sporting activities). They were divided into 4 groups each comprised of subjects ranged by age with a ten-year interval. Their mental working capacity was estimated from the results of the correction test.

[Features of bioelectric activity of the brain in epilepsy patients of elderly and senile age].

89 patients of elderly and senile age with various epilepsy forms have been examined. The general characteristic features of bioelectric brain activity of the elderly patients, suffering from epilepsy have been defined. Features of electroencephalographic (EEG) picture depending on the form of the disease, age of debut, expressiveness of cerebrovascular pathologies are revealed.

[Analysis of hemodynamics in late ontogenesis in subjects with different regimes of motor activity].

Th present study was designed to examine 409 practically healthy men at the age of 50 to 79 years differing in terms of daily locomotor activities. They were divided into 4 groups each comprising subjects whose age differed within 10 years. Group 1 included former high-class athletes continuing physical exercises.

[Efficiency of rehabilitation of elderly and senile patients after an ischemic stroke].

Productivity of a wide medical rehabilitation in 296 patients who have had an ischemic stroke was studied. In the period of rehabilitation treatment 186 patients of 70-84 years composed the basic group, 110 in the control group were of 33-60 years. Clinical, social, psychological indicators in dynamics were compared; results of variety of tool and laboratory researches were estimated.

[Age-related dynamics of the maximum oxygen consumption associated with different regimens of locomotor activity].

This study included a total of 234 practically healthy men at the age from 40 to 69 years differing in the regimen of daily locomotor activity. They were divided into 4 groups, each comprised of subjects ranged by age with a ten-year interval. Group 1 included former high-level athletes continuing active physical training, group 2 was comprised of former high-level athletes living a sedentary life style, group 3 consisted of subjects regularly engaged in health-giving physical exercises, and group 4 included subjects who were never engaged in physical exercises.

[Current problems in mutual relations of cerebral vascular and cardiovascular diseases in elderly and senile age].

The authors have been taking up the problems of the cardiovascular pathology caused by atherosclerosis for many years, and are supporters of universality of the specified pathology. The article demonstrates the results of the researches executed by authors, and other leaders of this direction in a medical science. Questions of mutual relations of various diseases of cardiovascular system on clinical, pathogenetic, pathomorphological, biochemical levels are considered.

[The effect of different regimes of motor activity on age-specific dynamics of the main functional systems of the organism].

The present study included 229 healthy men having different habitual patterns of daily locomotor activity. They were allocated to 4 groups encompassing subjects of different age. Group 1 consisted of medium-level athletes and subjects regularly engaged in physical exercises, group 2 included former high-level athletes continuing active physical training, group 3 was comprised of former high-level athletes living a sedentary life style, and group 4 included subjects who were never engaged in physical exercises.

[Clinical and pathogenetic characteristics of the craniocerebral trauma received by elderly patients after stroke].

In 174 patients of elderly and senile age features of a clinical picture and pathogenesis of a craniocerebral trauma of a different severity occurred in different terms after the previous stroke and in different circumstances have been studied. The mutual relations of traumatic and vascular processes are complex, the vascular pathogenetic features of a trauma influence actively to the brain, earlier damaged by an ischemic stroke, increasing the probability of the heavy form of a combined cerebral pathology and the unfavourable forecast. However the vascular encephalopathy in these conditions "does not develop" in posttraumatic one and chronic vascular-brain frustration absolutely prevail in all cases above traumatic ones.

[Gerontology aspects of the post-war medicine (about the present and the future of hospitals for veterans of wars)].

This article takes up the problems arisen around the largest hospitals for veterans of wars in a situation of considerable reduction of number of veterans, first of all the former participants of the World War II. The author emphasizes the value and urgency of gerontology researches which are made on clinical bases of large hospitals for war veterans and demand the continuation. The author sees many scientific directions of so-called post-war medicine within the limits of clinical and fundamental gerontology.

[The final state of lipid peroxidation and antioxidation activity in blood system of elderly patients with cardiovascular pathology].

The state of lipid peroxidation and antioxidation activity in blood system of 118 elderly patients with some forms of cardiovascular pathology was analyzed 2-4 days before death due to various causes--cardiovascular, cerebrovascular, malignant tumours. Distinct differences in the state of lipid peroxidation and antioxidation activity in blood system was revealed as regards to some forms of cardiovascular pathology and combinations of cardiovascular pathology with other diseases, in particular malignant tumours. Most aggressive changes of indexes in the lipid peroxidation were registered in patients with ischemic strokes.

[Evoked potentials of the brain in early diagnostics of the cognitive disorders in the elderly patients with cardiovascular pathology].

The changes of visual, acoustic and cognitive evoked potentials of brain in 78 elderly patients were studied. Chronic ischemia of the heart and the brain with clinical signs of mild cognitive impairment was present in all patients. Distinct pathomorphologycal sings of structure disorders in brain were absent, and this fact was confirmed with the help of neuroimaging investigations.

[Cardiovascular pathology in old patients with fatal malignant tumours].

The matter under analyses were clinical and pathomorphological peculiarities of the cardiovascular pathology in old patients with fatal malignant tumours. All patients had been treated in hospital, but notwithstanding died with causal of the malignant tumours. Pathomorphological investigation revealed lesser expressiveness of the atherosclerosis in aorta, arteries of braining foundation, coronaric arteries in patients with fatal malignant tumours as compared with patients, who died with causal of the cardiovascular pathology.

[Cardiovascular and cerebrovascular pathology in old patients: clinical and morphological aspects of interrelations].

The matter under observations and studies were 190 old patients with cardiovascular and cerebrovascular pathology. All the patients had been treated in hospital over and over again, but notwithstanding died with causal or the acute infarct of myocardium and its consequences (n=145), or the ischemic stroke (n=45). Pathomorphological investigation covering definition of clinical and morphological interrelations between two main marks of vascular diseases - brain and myocardium was carried out in all cases.

[Some problems of interrelations between ischemic stroke and cranial-cerebral trauma in elderly and aged patients].

The matters under studies were interrelations between cranial-cerebral trauma and ischemic stroke in old patients. Cranial-cerebral trauma took place before ischemic stroke in 80 cases. Ischemic stroke took place before cranial-cerebral trauma in 174 cases.

[Dynamics of lipid peroxidation and antioxidant defense processes in elderly patients during preparation to ophtalmosurgical interventions].

The changes of indices of the lipid peroxidation and antioxidant activity in elderly patients were studied. All the patients had cardiovascular pathology and had been getting ready for ophthalmology interventions about cataract. It is ascertained that the dynamics of lipid peroxidation and antioxidant activity indices connected with pre-surgery therapy can be the authentic prognosis criterion in regard to safety of an operation and possible cardiovascular complications.

[Accelerated senescence of armed conflicts participants suffering from the consequences of war cranial-cerebral trauma and alcoholism].

The matter under studies was the way accelerated senescence of armed conflicts participants with brain injuries depends on alcohol addiction developed after the injuries and on dysfunction of neurohumoral regulation of heart activity. It has been established that the posttraumatic alcohol addiction considerably activates the processes of accelerated senescence and lipid peroxidation connected with it, depresses the system of antioxidant protection and enhances the progress of dysfunctions in neurohumoral regulation of heart activity.

[Information conception of the control at aging].

The exchange of energy between organism and environment perhaps may be to describe with help "entropia"--notion of thermodynamics. Point of view information technologies authors suggest to use "factor of controls", which work with help principle of reverse biological connection. This principle may be to use for control aging, when complicated modulated electromagnetic (information) field has regulationing negative entropic component.