Publications by authors named "Miailhe A"
Article Synopsis
- Leptospirosis is more prevalent in tropical regions but can require ICU care globally; this study compares severe cases in Réunion (tropical) and mainland France (temperate) to understand clinical outcomes and characteristics.
- The study analyzed two groups of ICU patients with severe leptospirosis, finding that while patient demographics differed (e.g., metropolitan patients were older), severity, length of stay, and mortality rates were similar across both regions.
- Three distinct clinical phenotypes were identified: hepato-renal leptospirosis (54.5% with 8.3% mortality), moderately severe leptospirosis (38.5% with 1.8% mortality), and very severe leptospirosis (7
Article Synopsis
- The study investigates the impact of socio-economic status on respiratory issues in survivors of ARDS due to COVID-19, finding that 40% of patients were socio-economically deprived.
- After a follow-up of 6 months post-ICU, 80% of the 401 patients showed respiratory issues, but socio-economic status did not significantly affect the prevalence of these complications.
- The results suggest that, regardless of socio-economic background, the majority of ARDS survivors experienced respiratory sequelae, indicating the widespread impact of COVID-19 on lung health.
Article Synopsis
- * A new multicentre study, called RECOVIDS, aims to explore how social vulnerability impacts recovery in patients who were hospitalized for ARDS related to COVID-19, incorporating both quantitative measurements and qualitative insights into patient experiences.
- * The study will examine patients admitted to intensive care for severe COVID-19 and track their lung health six months post-discharge, focusing on identifying lung sequelae through various tests and assessing the role of socio-economic status in their rehabilitation process.
Background: Alcohol withdrawal syndrome (AWS) is a common condition in hospitalized patients, yet its epidemiology in the ICU remains poorly characterized.
Methods: Retrospective cohort of patients admitted to the Nantes University Hospital ICU between January 1, 2017, and December 31, 2019, and coded for AWS using ICD-10 criteria. The objective of the study was to identify factors associated with complicated hospital stay defined as ICU length of stay ≥7 days or hospital mortality.
Article Synopsis
- A retrospective multicenter study analyzed 382 patients admitted to ICUs for acute cholangitis (AC) from 2005 to 2018, noting a 29% in-hospital mortality rate.
- Factors linked to higher mortality included SOFA score, lactate levels, total serum bilirubin, and complications from AC.
- Over time, mortality rates improved significantly, particularly with prompt biliary decompression; delays of more than 48 hours were associated with increased risk of death.
Purpose: Prognostication of hypoxic-ischaemic brain injury after resuscitation from cardiac arrest is based on a multimodal approach including biomarker assays. Our goal was to assess whether plasma NSE helps to predict day-90 death or poor neurological outcome in patients resuscitated from cardiac arrest in non-shockable rhythm.
Methods: All included patients participated in the randomised multicentre HYPERION trial.
Background: Intubation is a lifesaving procedure that is often performed in intensive care unit (ICU) patients, but leads to serious adverse events in 20-40% of cases. Recent trials aimed to provide guidance about which medications, devices, and modalities maximize patient safety. Videolaryngoscopes are being offered in an increasing range of options and used in broadening indications (from difficult to unremarkable intubation).
View Article and Find Full Text PDFPurpose: To report the incidence, risk factors, clinical presentation, and outcome predictors of severe leptospirosis requiring intensive care unit (ICU) admission in a temperate zone.
Methods: LEPTOREA was a retrospective multicentre study conducted in 79 ICUs in metropolitan France. Consecutive adults admitted to the ICU for proven severe leptospirosis from January 2012 to September 2016 were included.
Objectives: Metabolic acidosis is commonly observed in critically ill patients. Experimental studies suggested that acidosis by itself could impair vascular function, but this has been poorly investigated in human.
Design: Prospective observational study.
In mice, the early host response to intravenous infection with small doses of dispersed Mycobacterium bovis BCG is controlled by the Bcg gene. After infection with a low dose of M. bovis BCG, Lyt-1+ cells were generated in the spleens of BCG-susceptible mice (Bcgs) in parallel with an increase in the proportion of phagocytic cells.
View Article and Find Full Text PDFIntravenous infection of six inbred mouse strains with small doses of dispersed cells of Mycobacterium bovis BCG (15.5 x 10(3) or 15.5 x 10(4) colony-forming units) separated them into resistant (C3H/HeCr, A/J, and DBA/2) and sensitive (B10.
View Article and Find Full Text PDF