Publications by authors named "Mia Ravn Jacobsen"
Background: Transcatheter mitral valve repair is performed in a patient population at risk for thrombotic and bleeding events. The effects on platelet function and reactivity and their association with bleeding events after mitral transcatheter edge-to-edge therapy (M-TEER) have not been systematically examined.
Objectives: We sought to investigate the association of different parameters of platelet function and thrombogenicity with bleeding events post M-TEER.
Article Synopsis
- The study aimed to assess if having a family history of unexplained heart failure (HF) in first-degree relatives increases the likelihood of developing unexplained HF themselves.
- An analysis of Danish nationwide registry data from 1978 to 2017 found that first-degree relatives of probands with unexplained HF had a significantly higher incidence rate of HF, particularly among siblings and when the proband was diagnosed at a younger age.
- The findings suggest that relatives of individuals with early-onset unexplained HF should be screened more closely due to the increased risk of developing the condition themselves.
Bleeding risk and P2Y12 inhibitors in all-comer patients with ST-segment elevation myocardial infarction treated with percutaneous coronary intervention: a single-centre cohort study.
Eur Heart J Cardiovasc Pharmacother
November 2023
Article Synopsis
- A study aimed to assess STEMI patients at high bleeding risk (HBR) based on the PRECISE-DAPT score, investigating their treatment options and associated outcomes after stent implantation and dual antiplatelet therapy.
- The analysis included 6179 STEMI patients over several years, showing that 33% were classified as HBR, predominantly elderly females with more health issues, and revealing significant differences in bleeding and major adverse cardiovascular events (MACE) rates between HBR and non-HBR patients.
- The findings indicated that HBR patients were more often prescribed stronger P2Y12 inhibitors like ticagrelor or prasugrel compared to clopidogrel, suggesting a trend toward prioritizing ischemic risk
Article Synopsis
- The study focused on patients with ST-segment elevation myocardial infarction (STEMI) and explored the outcomes of those who underwent percutaneous coronary intervention (PCI) without stenting compared to those who received immediate stenting.
- Results showed that in a follow-up period of 3.4 years, patients who did not receive stenting had similar rates of major adverse events, including mortality and recurrent myocardial infarctions, as those who underwent immediate stenting.
- The findings suggest that in cases where there is no significant residual stenosis and stable blood flow post-PCI, stenting might be unnecessary, potentially leading to less invasive treatment options for STEMI patients.
Background: To compare effectiveness and safety of clopidogrel, prasugrel, and ticagrelor among all-comers with ST-segment elevation myocardial infarction (STEMI) and extend the knowledge from randomized clinical trials.
Methods: All consecutive patients with STEMI admitted to Copenhagen University Hospital, Rigshospitalet, from 2009 to 2016 were identified via the Eastern Danish Heart Registry. By individual linkage to Danish nationwide registries, claimed drugs and end points were obtained.
Background: New-onset atrial fibrillation (NEW-AF) following ST-segment elevation myocardial infarction (STEMI) is a common complication, but the true prognostic impact of NEW-AF is unknown. Additionally, the optimal treatment of NEW-AF among patients with STEMI is warranted.
Methods: A large cohort of consecutive patients with STEMI treated with percutaneous coronary intervention were identified using the Eastern Danish Heart Registry from 1999-2016.
Aims: To investigate seasonality and association of increased enterovirus and influenza activity in the community with ventricular fibrillation (VF) risk during first ST-elevation myocardial infarction (STEMI).
Methods: This study comprised all consecutive patients with first STEMI (n = 4,659; aged 18-80 years) admitted to the invasive catheterization laboratory between 2010-2016, at Copenhagen University Hospital, Rigshospitalet, covering eastern Denmark (2.6 million inhabitants, 45% of the Danish population).
Background Potassium disturbances per se increase the risk of ventricular fibrillation (VF). Whether potassium disturbances in the acute phase of ST-segment-elevation myocardial infarction (STEMI) are associated with VF before primary percutaneous coronary intervention (PPCI) is uncertain. Methods and Results All consecutive STEMI patients were identified in the Eastern Danish Heart Registry from 1999 to 2016.
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