Optimization of the extraction methods and evaluation of the hypoglycemic effect of extracts on artificially induced diabetic mice.

Synthetic antidiabetic drugs are often associated with various adverse side effects, including hypoglycemia, nausea, gastrointestinal disturbances, headaches, and even liver damage. In contrast, plant-derived natural antidiabetic bioactive compounds typically exhibit lower toxicity and fewer side effects and have been reported to aid effectively in diabetes management. These plant extracts regulate diabetes by restoring pancreatic function, enhancing insulin secretion, inhibiting intestinal glucose absorption, and facilitating insulin dependent metabolism.

Investigating the impact of oligo-chitosan on the growth dynamics and yield traits of L. 'BRRI dhan29' under subtropical conditions.

Reducing the harmful chemical use along with obtaining potential yield in field is a worth exploring practice in rice cultivation. To mitigate the prevailing yield gap, the current study was designed to evaluate the effect of chitosan in improving growth, yield contributing characters and yield of rice. The experiment comprised eight different treatments control (no fertilizer and Chitosan) (T), conventional method (with fertilizers) (T), conventional method with foliar spray of 100 ppm chitosan solution (T), conventional method with foliar spray of 300 ppm chitosan solution (T), conventional method with foliar spray of 500 ppm chitosan solution (T), only foliar spray of 100 ppm chitosan solution (T), only foliar spray of 300 ppm chitosan solution (T), and only foliar spray of 500 ppm chitosan solution (T).

Assessment of thiamine and riboflavin levels in common green leafy vegetables grown in Shariatpur, Bangladesh.

Thiamine (vitamin B1) and riboflavin (vitamin B2) are essential vitamins because of their important health impact. Twelve different green leafy vegetable-samples including , and indigenous to Shariatpur district in Bangladesh were collected, dried, stored and analyzed. The extraction procedures involved acid hydrolysis followed by enzymatic hydrolysis of the dried vegetable samples.

Yogurt Supplementation Can Ameliorate Fatty Liver Diseases and Metabolic Syndrome in High Fat-Induced Conditions in Mice.

Hepatic steatosis/non-alcoholic fatty liver disease is a major public health delinquent caused by the excess deposition of lipid into lipid droplets (LDs) as well as metabolic dysregulation. Hepatic cells buildup with more fat molecules when a person takes high fat diet that is excessive than the body can handle. At present, millions of people in the world are affected by this problem.

Phytochemical Profiling and Pharmacological Evaluation of Methanolic Leaf Extract of for Cytotoxic, Anti-inflammatory, Antioxidant, Antiarthritic, and Analgesic Activities.

(Family: Fabaceae) is traditionally used in Ayurvedic medicine for various medicinal purposes, including as a treatment for wounds, leprosy, skin diseases, fever, diabetes, etc. Although the root and stem of this plant have a significant medicinal value, there was little research on the leaves of this plant. This study aimed to investigate the qualitative phytochemical profile and evaluate the in vitro cytotoxic, anti-inflammatory, antioxidant, and antiarthritic activities, as well as the in vivo anti-inflammatory and analgesic activities, of leaf extract.

Spatiotemporal dynamics of geomorphology, landuse, and storm surge inundation of FDMN settled in Bhasan Char island using geo-spatial techniques.

Bhasan Char has undergone noteworthy transformations in its geographical characteristics since its emergence in 2003. Driven by sediment transported by the Ganges-Brahmaputra-Meghna river system, the island has gradually transitioned from a stretched-out configuration to a more rounded shape primarily due to continuous accretion, while erosion has been minimal since 2012. Currently, the island is being prepared to accommodate over 1 million Forcefully Displaced Myanmar Nationals (FDMN) refugees.

HMGA2 overexpression with specific chromosomal abnormalities predominate in CALR and ASXL1 mutated myelofibrosis.

Although multiple genetic events are thought to play a role in promoting progression of the myeloproliferative neoplasms (MPN), the individual events that are associated with the development of more aggressive disease phenotypes remain poorly defined. Here, we report that novel genomic deletions at chromosome 12q14.3, as detected by a high-resolution array comparative genomic hybridization plus single nucleotide polymorphisms platform, occur in 11% of MPN patients with myelofibrosis (MF) and MPN-accelerated/blast phase (AP/BP) but was not detected in patients with polycythemia vera or essential thrombocythemia.

Variations in Furin SNPs, a Major Concern of SARS-CoV-2 Susceptibility Among Different Populations: An - Approach.

COVID-19 caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) had an adverse effect globally because it caused a global pandemic with several million deaths. This virus possesses spike protein that is cleaved or activated by Furin-like protease enzymes occurring by mammalian lung or respiratory cells to enter the mammalian body. The addition of the Furin cleavage site in SARS-CoV-2 makes it a more infectious and emerging virus than its ancestor's viruses.

Trophic status analysis and nutrient source allocation in urban lakes of Dhaka, Bangladesh: a comprehensive approach to eutrophication monitoring.

Urban lakes are vital to ecosystems, providing essential services and recreational spaces in densely populated megacities. However, rapid urbanization and anthropogenic activities, particularly eutrophication driven by macronutrient accumulation, severely threaten these water bodies. This study underscores the critical need for continuous trophic state monitoring to sustain fish, wildlife, and plant ecosystems.

Evaluation of thiamine and riboflavin in different varieties of rice grown in Kurigram district, Bangladesh.

Context: Rice is indeed a staple food in many parts of the world, including Bangladesh. This research aimed to evaluate the two essential vitamin levels in different processed rice sunned, parboiled, cooked sunned, cooked parboiled, and washed cooked rice.

Objective: The study focused on analyzing the thiamine (vitamin B) and riboflavin (vitamin B) contents in 10 different varieties of paddy samples grown in the Kurigram district of Bangladesh.

Selective targeting of phosphodiesterases to develop potent antiparasitic drugs.

Regulation of intracellular cyclic nucleotides to avoid homeostatic imbalances is achieved through catabolic activity of phosphodiesterases (PDEs). Recently, Ajiboye et al. reported validation of Cryptosporidium PDE1 (CpPDE1) as a viable drug target and identified optimized pyrazolopyrimidines with selective activity against CpPDE1 over human PDEs and with potent anticryptosporidial efficacy.

StackIL10: A stacking ensemble model for the improved prediction of IL-10 inducing peptides.

Interleukin-10, a highly effective cytokine recognized for its anti-inflammatory properties, plays a critical role in the immune system. In addition to its well-documented capacity to mitigate inflammation, IL-10 can unexpectedly demonstrate pro-inflammatory characteristics under specific circumstances. The presence of both aspects emphasizes the vital need to identify the IL-10-induced peptide.

Strain effect on the electronic and optical characteristics of FAGeX (X=Cl, Br, and I) perovskite materials: DFT analysis.

This study investigates the electronic and optical properties of a perovskite material known as Formamidinium Germanium Halide (FAGeX), where X represents the elements Chlorine (Cl), Bromine (Br), and Iodine (I). We explore the bandgap, density of state (DOS), and partial density of state (PDOS) to understand their electronic properties. We use two methods, PBE and HSE-06, to determine the bandgap.

A critical review on heavy metal contamination in aquatic food webs by edible fish species: a special case concerning Bangladesh.

Heavy metals (HMs) are ubiquitous in terrestrial and aquatic environments due to unplanned industrial waste discharge, the release of untreated wastewater, and improper mining activities. In particular, the concentrations of HMs are found to be higher in aquatic environments. As a result, the aquatic biota was heavily affected by HM contamination.

Pentacyclic Triterpenoid Content in Cranberry Raw Materials and Products.

Cranberry fruit extracts have been shown to inhibit expression of pro-inflammatory cytokines in THP-1 cells and reduce colonic tumor burden and tissue inflammation in a mouse model of colitis. These activities are attributed to both the triterpenoid and polyphenol constituents of the fruit. The pentacyclic triterpenoids ursolic acid (UA), oleanolic acid (OA), corosolic acid (CA), maslinic acid (MA), and esters of UA and OA occur in the waxy layer of cranberry peel, and their content in cranberry products is likely to vary with the fruit source and processing methods.

Heat stress tolerance in wheat seedling: Clustering genotypes and identifying key traits using multivariate analysis.

Elevated atmospheric heat is considered as one of the bottlenecks for global wheat production. Screening potential wheat genotypes against heat stress and selecting some suitable indicators to assist in understanding thermotolerance could be crucial for sustaining wheat cultivation. Accordingly, 80 diverse bread wheat genotypes were evaluated in controlled lab condition by imposing a week-long heat stress (35/25 C D/N) at the seedling stage.

Designing and development of efficient multi-epitope-based peptide vaccine candidate against emerging avian rotavirus strains: A vaccinomic approach.

Background: Enteric avian rotavirus (ARV) is the etiological agent of several health problems that pose a global threat to commercial chickens. Therefore, to avoid these widespread epidemics and high mortality rates, only vaccine and strict biosecurity are required.

Method: The present study employs computational techniques to design a unique multi-epitope-based vaccine candidate that successfully activates immune cells against the ARV by combining adjuvant, linker, and B and T-cell epitopes.

Preclinical and Clinical Investigations of Potential Drugs and Vaccines for COVID-19 Therapy: A Comprehensive Review With Recent Update.

The COVID-19 pandemic-led worldwide healthcare crisis necessitates prompt societal, ecological, and medical efforts to stop or reduce the rising number of fatalities. Numerous mRNA based vaccines and vaccines for viral vectors have been licensed for use in emergencies which showed 90% to 95% efficacy in preventing SARS-CoV-2 infection. However, safety issues, vaccine reluctance, and skepticism remain major concerns for making mass vaccination a successful approach to treat COVID-19.

approach to characterize the structure and function of a hypothetical protein of Monkeypox virus exploring Chordopox-A20R domain-containing protein activity.

Monkeypox has emerged as a noteworthy worldwide issue due to its daily escalating case count. This illness presents diverse symptoms, including skin manifestations, which have the potential to spread through contact. The transmission of this infectious agent is intricate and readily transfers between individuals.

Catch composition, catch per unit effort (CPUE) and species selectivity of fishing gears on multi-species Kaptai Lake in Bangladesh.

Kaptai Lake, the largest artificial reservoir in Southeast Asia, is home to a diverse fish fauna that supports thousands of livelihoods and is distinguished by multi-species and multi-gear fisheries. In Kaptai Lake, the gear-based catch composition, catch rate and distribution pattern are little known. From August 2020 to April 2021, a nine-month study was conducted in five using direct catch assessment surveys and fishing effort surveys from four fishing gears, namely seine nets, gill nets, lift nets, and push nets.

In silico functional, structural and pathogenicity analysis of missense single nucleotide polymorphisms in human MCM6 gene.

Single nucleotide polymorphisms (SNPs) are one of the most common determinants and potential biomarkers of human disease pathogenesis. SNPs could alter amino acid residues, leading to the loss of structural and functional integrity of the encoded protein. In humans, members of the minichromosome maintenance (MCM) family play a vital role in cell proliferation and have a significant impact on tumorigenesis.

Investigating the potent TOPO IIα inhibitors in breast cancer through the study of computational drug discovery research approaches.

Breast cancer (BC) is the second-leading cause of cancer after lung cancer. The disease has affected millions of people and resulted in many deaths. In the metastasis of breast cancer cells, Topoisomerase IIα plays a vital role.