Publications by authors named "Mi-Tao Huang"
Recently studies found that APEX1 was abnormally expressed in melanoma, indicating that it might be involved in the development of melanoma. However, the underlying mechanism and the interaction between APEX1 and LINC00470 in melanoma are not clear. Therefore, we aimed to investigate the role of LINC00470 in the development of melanoma in this work.
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- Diabetes often leads to chronic wounds, and the long non-coding RNA (lncRNA) GAS5 plays a role in regulating healing processes affected by high glucose levels.
- Research using various cellular and animal models found that GAS5 is down-regulated while miR-217 is up-regulated in diabetic conditions, impacting cell viability, migration, and vessel formation.
- The study concludes that GAS5 can inhibit miR-217 to enhance Prox1 expression, thereby promoting lymphangiogenesis and improving wound healing in diabetic models, suggesting a potential new therapeutic approach.