Publications by authors named "Mi-Na Kim"
Background: This study aimed to identify risk factors associated with the implementation of veno-arterial extracorporeal membrane oxygenation (VA-ECMO) in patients with acute myocarditis and to develop a predictive model.
Methods And Results: This retrospective study included 841 patients from 7 hospitals in Korea with biopsy-proven or clinically suspected acute myocarditis. Logistic regression analysis was used to identify the clinical characteristics of patients who required VA-ECMO and to construct a scoring system to predict the implementation of VA-ECMO.
[Noninvasive Imaging Test to Assess Liver Fibrosis: Vibration-controlled Transient Elastography].
Korean J Gastroenterol
November 2024
Liver fibrosis refers to the formation of scar tissue in the liver when inflammation persists over a long period. Assessing liver fibrosis is crucial for predicting the prognosis of chronic liver disease and managing patients with these conditions. Although a liver biopsy remains the gold standard for assessing liver fibrosis, it is limited by its invasive nature.
View Article and Find Full Text PDFBackground: Adherence to oral anticoagulant therapy is essential to prevent ischemic stroke in patients with atrial fibrillation (AF).
Objective: This study aimed to evaluate whether smartphone app-based interventions improve medication adherence in patients with AF.
Methods: This open-label, multicenter randomized controlled trial (ADHERE-App [Self-Awareness of Drug Adherence to Edoxaban Using an Automatic App Feedback System] study) enrolled patients with AF treated with edoxaban for stroke prevention.
Unlabelled: The FilmArray Pneumonia Panel (FilmArrayPN; bioMérieux) was tagged for potential false-positive seasonal coronavirus results, possibly caused by non-specific amplification or cross-reactivity with human genomic DNA. This study was conducted to determine the real-world false-positive rate of seasonal coronavirus infections using FilmArrayPN at a tertiary care hospital. We retrospectively reviewed FilmArrayPN results to detect lower respiratory tract pathogens from July 2023 to April 2024.
View Article and Find Full Text PDFAims: Whether medication adherence to angiotensin receptor-neprilysin inhibitor (ARNI) in real-world practice is associated with the reduced risk of all-cause mortality or hospitalization relative to that with traditional renin-angiotensin system (RAS) blockade remains unclear. This study investigated the influence of medication adherence of ARNI and traditional RAS blockade in heart failure with reduced ejection fraction (HFrEF).
Method: We conducted a nationwide longitudinal cohort study with patients with HFrEF using data from the Korean National Health Insurance Service data (2017-2021) covering the entire population.
Article Synopsis
- A study aimed to investigate the incidence of metabolic dysfunction-associated steatotic liver disease (MASLD) and its progression to advanced fibrosis in individuals aged 60 and older, revealing a growing concern as this population expands.* -
- Researchers analyzed data from 329,388 seniors, finding an overall MASLD incidence rate of 1.94 per 100 person-years, which increased significantly in people who were overweight or obese.* -
- The results highlight that overweight/obesity is a strong predictor for both MASLD and advanced fibrosis in older adults, emphasizing the need to identify age-specific risk factors for better health outcomes in this demographic.*
Article Synopsis
- The study investigates candidemia caused by a specific yeast complex, focusing on both single and serial infection episodes in patients at a Korean hospital from 2019 to 2023.
- A total of 586 blood isolates were collected from 68 patients, with only the first isolate analyzed, revealing minimal antifungal resistance and different clinical outcomes for patients with single versus serial episodes, though the 30-day mortality rates were similar.
- Results suggest that underlying health conditions, such as liver disease and ICU admission, are more relevant to repeated candidemia episodes than the properties of the yeast itself.
Background & Aims: We investigated the association of physical activity (PA) levels and changes with the risk of hepatocellular carcinoma (HCC) in patients with type 2 diabetes.
Methods: Patients with type 2 diabetes who had undergone health examinations in 2009 and 2011 were enrolled. In total, 1,439,152 patients were included in the analysis.
Background And Aims: Antiviral therapy (AVT) is required in patients with newly diagnosed hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC), if HBV DNA is detectable. We compared the risk of recurrence according to HBV replication activity at the curative treatment of HBV-related HCC.
Methods: Patients with HBV-related HCC who underwent surgical resection or radiofrequency ablation between 2013 and 2018 were enrolled in this retrospective cohort study.
Backgrounds/aims: This meta-analysis examined whether preoperative vibration-controlled transient elastography (VCTE) can predict postoperative complications and recurrence in patients undergoing hepatic resection for hepatocellular carcinoma (HCC).
Methods: A systematic literature search was conducted using Ovid-Medline, EMBASE, Cochrane, and KoreaMed databases. Out of 431 individual studies, thirteen published between 2008 and 2022 were included.
Background/aims: Opinions differ regarding vibration-controlled transient elastography and magnetic resonance elastography (VCTE/MRE) cut-offs for diagnosing advanced fibrosis (AF) in patients with non-alcoholic fatty liver disease (NAFLD). We investigated the diagnostic performance and optimal cut-off values of VCTE and MRE for diagnosing AF.
Methods: Literature databases, including Medline, EMBASE, Cochrane Library, and KoreaMed, were used to identify relevant studies published up to June 13, 2023.
Article Synopsis
- The study evaluates the effectiveness of vibration-controlled transient elastography (VCTE) in diagnosing liver fibrosis in autoimmune liver diseases like primary biliary cholangitis (PBC), autoimmune hepatitis (AIH), and primary sclerosing cholangitis (PSC).
- A meta-analysis of 14 studies involving 1,098 patients showed that VCTE performs well for fibrosis staging, with strong area under the curve (sAUC) values for different stages of fibrosis across all three diseases.
- The findings suggest that VCTE is a reliable non-invasive tool for assessing and monitoring liver fibrosis in patients with autoimmune liver diseases.
Article Synopsis
- Despite advancements in hepatitis C therapy, hepatocellular carcinoma (HCC) can still occur after patients achieve sustained viral response (SVR), prompting a study on the predictive capabilities of vibration-controlled transient elastography (VCTE) and fibrosis 4-index (FIB-4) for HCC development post-SVR.
- The meta-analysis included 27 studies with a total of 169,911 patients, assessing the tests' performance in predicting HCC using pooled estimates of sensitivity, specificity, and area under the curve (AUC).
- The results indicated that both VCTE and FIB-4 have good predictive capabilities for HCC development after SVR, with optimal cut-off values identified for risk assessment, highlighting
Rationale, Design, and Interim Observations of the Steady Movement With Innovating Leadership for Heart Failure (SMILE HF) Registry: A Multicenter Prospective Cohort Registry for Patients With Acute Heart Failure.
Int J Heart Fail
July 2024
Background And Objectives: Heart failure (HF) is a leading cause of hospitalization and death worldwide. The Steady Movement with Innovating Leadership for Heart Failure (SMILE HF) aims to evaluate the clinical characteristics, management, hospital course, and long-term outcomes of patients hospitalized for acute HF in South Korea.
Methods: This prospective, observational multicenter cohort study was conducted on consecutive patients hospitalized for acute HF in nine university hospitals since September 2019.
Article Synopsis
- Researchers aimed to determine the prevalence of clinically significant liver fibrosis in the general population using noninvasive tests (NITs).
- They analyzed data from four major databases and included 45 studies, finding the prevalence rates of advanced liver fibrosis to be 2.3% and significant liver fibrosis to be 7.3%.
- The highest prevalence rates were observed in the American region, indicating a need for further research to identify at-risk individuals in the general population.
The gut microbiome significantly influences immune responses and the efficacy of immune checkpoint inhibitors. We conducted a clinical trial (NCT04264975) combining an anti-programmed death-1 (PD-1) inhibitor with fecal microbiota transplantation (FMT) from anti-PD-1 responder in 13 patients with anti-PD-1-refractory advanced solid cancers. FMT induced sustained microbiota changes and clinical benefits in 6 of 13 patients, with 1 partial response and 5 stable diseases, achieving an objective response rate of 7.
View Article and Find Full Text PDFArticle Synopsis
- - The Fibrosis-4 index (FIB-4) is a noninvasive test used to assess advanced liver fibrosis (AF) in patients with nonalcoholic fatty liver disease (NAFLD), though its effectiveness in those with type 2 diabetes mellitus (T2DM) is debated due to high AF rates in this group.
- - A meta-analysis of 12 studies involving 5,624 NAFLD patients with T2DM revealed that FIB-4 has moderate sensitivity and specificity, particularly showing better performance at high cutoffs (high specificity but lower sensitivity).
- - While FIB-4 can be useful for diagnosing AF, the current evidence is limited and varied, suggesting a need for more research to
Backgrounds/aims: Accurate diagnosis of significant liver fibrosis in patients with chronic hepatitis B (CHB) is crucial when determining whether to initiate antiviral treatment (AVT). We conduct a meta-analysis to assess the diagnostic performance of vibration-controlled transient elastography (VCTE) for significant liver fibrosis in AVT-naïve CHB patients with serum alanine transaminase (ALT) levels within 5-fold the upper limit of normal (ULN).
Methods: The Ovid-Medline, EMBASE, Cochrane, and KoreaMed databases were searched to identify studies that compared the performance of VCTE and liver biopsy (reference standard) when diagnosing significant liver fibrosis (≥F2) in AVT-naïve CHB patients with ALT within 5-fold the ULN.
Backgrounds/aims: Liver stiffness measurement (LSM) using vibration-controlled transient elastography (VCTE) can assess fibrotic burden in chronic liver diseases. The systematic review and meta-analysis was conducted to determine whether LSM using VCTE can predict the risk of development of hepatocellular carcinoma (HCC) in chronic hepatitis B (CHB) patients.
Methods: A systematic literature search of the Ovid-Medline, EMBASE, Cochrane, and KoreaMed databases (from January 2010 to June 2023) was conducted.
Hepatocellular carcinoma (HCC) is undergoing a transformative shift, with metabolic-associated fatty liver disease (MAFLD) emerging as a dominant etiology. Diagnostic criteria for MAFLD involve hepatic steatosis and metabolic dysregulation. Globally, MAFLD prevalence stands at 38.
View Article and Find Full Text PDFClinical evaluation of the T2Candida assay for the rapid diagnosis of candidemia.
Diagn Microbiol Infect Dis
September 2024
We evaluated the clinical performance of the T2Candida assay. The overall agreement of the T2Candida assay results with the blood culture results was 95.3 % (121/127).
View Article and Find Full Text PDFAims: Assessing the risk for HF rehospitalization is important for managing and treating patients with HF. To address this need, various risk prediction models have been developed. However, none of them used deep learning methods with real-world data.
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