Publications by authors named "Mi Young Cho"

Article Synopsis
  • Cell-based immunotherapies show promise for cancer treatment, but there's a need for better experimental models that mimic clinical settings to study their effects.
  • This study investigates using three-dimensional (3D) scaffold-based cell cultures to support immune cell growth and continuous cancer cell monitoring, particularly focusing on A549 lung cancer cells and natural killer (NK) cells.
  • The results indicate that 3D cultures reveal greater drug resistance in solid tumor cells and increased expression of markers related to cancer progression compared to traditional 2D cultures, making 3D models a valuable tool for understanding and improving NK cell therapies.
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  • * The study introduces a new imaging technique that non-invasively tracks NK cell activation by using a genetic modification to bind the STAT1 protein when NK cells are activated.
  • * Engineered NK cells (GAS-NK) show their effectiveness through various tests and real cancer models, providing a promising way to enhance monitoring of NK cell activity and potentially improving cancer treatment outcomes.
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  • Anomalous origin of the left pulmonary artery (AOLPA) is a rare congenital heart defect that requires careful detection during fetal echocardiography.
  • A 30-year-old pregnant woman had a fetal scan that identified AOLPA and a right-sided aortic arch, allowing for better planning of her delivery.
  • Early detection of AOLPA through prenatal diagnosis is essential for improving outcomes, highlighting the need for thorough examination during fetal echocardiography.
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Recently, extracellular vesicles (EVs) have been developed as therapeutic targets for various diseases. Biodistribution is crucial for EVs intended for therapeutic purposes because it can determine the degree of on- and off-target effects. This study aimed to explore techniques to evaluate the biodistribution of unmodified EVs.

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Aims: Heart transplantation is a well-established treatment for end-stage heart failure in paediatric patients, demonstrating excellent long-term outcomes.

Methods: This retrospective study analyses 35 years of data on 244 paediatric recipients (<18 years) at a single institution from 1986 to 2022. The analysis explores changes in diagnoses, survival, waiting times and mechanical circulatory support (MCS) over three decades (1991-2000, 2001-2010 and 2011-2020).

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Objectives: This study aimed to evaluate the short-/mid-term outcome of patients with complex dextro (d)-/levo (l)-transposition of the great arteries (TGA), ventricular septal defect and left ventricular outflow tract obstructions.

Methods: A single-centre, retrospective review of all complex dextro-TGA (n = 85) and levo-TGA (n = 22) patients undergoing different surgeries [Arterial switch operation + left ventricular outflow tract obstruction-resection (ASO-R), half-turned truncal switch/Mair (HTTS), Nikaidoh and Rastelli] between May 1990 and September 2022 was performed. Groups were analysed using Kruskal-Wallis test with post hoc pairwise comparison and Kaplan-Meier time-to-event models.

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Valosin-containing protein (VCP)/p97, an AAA+ ATPase critical for maintaining proteostasis, emerges as a promising target for cancer therapy. This study reveals that targeting VCP selectively eliminates breast cancer cells while sparing non-transformed cells by inducing paraptosis, a non-apoptotic cell death mechanism characterized by endoplasmic reticulum and mitochondria dilation. Intriguingly, oncogenic HRas sensitizes non-transformed cells to VCP inhibition-mediated paraptosis.

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Rock bream iridovirus (RBIV), belonging to Megalocytivirus, causes severe mortality in rock bream. Almost all deaths associated with RBIV are accompanied by splenic enlargement and anemia. Although red blood cells (RBCs) are involved in the immune response against viral infections, their involvement in rock bream has not yet been studied in terms of the immune response against RBIV.

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The impact of bacteria on cancer progression and treatment is becoming increasingly recognized. Cancer-associated bacteria are linked to metastases, reduced efficacy, and survival challenges. In this study, we present a sensitive hypoxia-activated prodrug, , which comprises an antibiotic combined with a chemotherapeutic.

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Mechanical support options for children and small adolescents with acute left ventricular failure are often limited to extracorporeal life support (ECLS) and subsequent left ventricular assist device implantation. We report a case of a 3-year-old child weighing 12 kg with acute humoral rejection after cardiac transplantation not adequately responding to medical therapy who presented in persistent low cardiac output syndrome. We successfully stabilized the patient by implanting a Impella 2.

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Article Synopsis
  • Natural killer (NK) cells are immune cells that could be used for advanced cancer treatments, but traditional therapies focused on one target can struggle due to tumor heterogeneity and relapse.
  • A new system called the split and universal cotinine-CAR (Cot-CAR) was developed, which allows NK cells to target multiple tumor antigens without needing extensive re-engineering.
  • The effectiveness of the Cot-CAR system was tested on various tumor cells, proving that it offers improved specificity, adaptability, and potential to better manage tumor relapse and cytolytic activity in cancer therapies.
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Auranofin (AF), a gold (I)-containing phosphine compound, is being investigated for oncological application as a repurposed drug. We show here that 4~5 µM AF induces paraptosis, a non-apoptotic cell death mode characterized by dilation of the endoplasmic reticulum (ER) and mitochondria, in breast cancer cells. Although the covalent inhibition of thioredoxin reductase (TrxR), an enzyme that critically controls intracellular redox homeostasis, is considered the primary mechanism of AF's anticancer activity, knockdown of TrxR1 did not induce paraptosis.

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Objective: The aim was to report mid-term performance of decellularized equine pericardium used for repair of various congenital heart defects in the pediatric population.

Methods: A retrospective review of all patients undergoing patch implantation between 2016 - 2020 was performed. Patch quality, surgical handling, hemostasis and early patch-related complications were studied on all patients.

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  • Miamiensis avidus is a parasitic pathogen that causes scuticociliatosis in fish and belongs to the ciliate group of protozoans, featuring a linear mitochondrial genome with 47 genes.
  • The complete mitochondrial genome measures 38,695 bp and includes 40 protein-coding genes, two rRNA genes, and five tRNA genes, showing significant differences from other ciliates in gene loss and stop codon usage.
  • This study is the first to sequence M. avidus' mt-genome, offering valuable insights for species identification, phylogenetic studies, and has potential applications in epidemiology and disease management in aquatic environments.
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The heterotypic CIC structures formed of cancer and immune cells have been observed in tumor tissues. We aimed to assess the feasibility of using heterotypic CICs as a functional biomarker to predict NK susceptibility and drug resistance. The heterotypic CIC-forming cancer cells showed a lower response to NK cytotoxicity and higher proliferative ability than non-CIC cancer cells.

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Background: Uneven hepatic venous blood flow distribution (HFD) to the pulmonary arteries is hypothesized to be responsible for the development of intrapulmonary arteriovenous malformations (PAVM) in patients with univentricular physiology. Thus, achieving uniform distribution of hepatic blood flow is considered favorable. However, no established method for the prediction of the post-interventional hemodynamics currently exists.

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Hypoxia is a feature of most solid tumors and a key determinant of cancer growth and propagation. Sensing hypoxia effectively could lead to more favorable clinical outcomes. Here, we report a molecular antenna-based bimodal probe designed to exploit the complementary advantages of magnetic resonance (MR)- and optical-based imaging.

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Background: There has been growing concern regarding the impact of air pollution, especially fine dust, on human health. However, it is difficult to estimate the toxicity of fine dust on the human body because of its diverse effects depending on the composition and environmental factors.

Results: In this study, we focused on the difference in the biodistribution of fine dust according to the size distribution of particulate matter after inhalation into the body to predict its impact on human health.

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Background: Bone marrow-derived mesenchymal stem cells (BMSCs) and bone morphogenetic protein-2 (BMP-2) have been studied for bone repair because they have regenerative potential to differentiate into osteoblasts. The development of injectable and in situ three-dimensional (3D) scaffolds to proliferate and differentiate BMSCs and deliver BMP-2 is a crucial technology in BMSC-based tissue engineering.

Methods: The proliferation of mouse BMSCs (mBMSCs) in collagen/poly-γ-glutamic acid (Col/γ-PGA) hydrogel was evaluated using LIVE/DEAD and acridine orange and propidium iodide assays.

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Several criteria to identify suitable candidates for anatomic repair in congenitally corrected transposition (cc-TGA) have been proposed. The purpose of this study was to critically re-evaluate adequacy of these recommendations in our patient cohort. All cc-TGA patients undergoing anatomic repair between 2010 and 2019 were reviewed.

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Double-chambered right ventricle (DCRV) is a progressive division of the right ventricular outflow tract (RVOT) often associated with a subaortic ventricular defect (VSD). The septation is caused by a mixture of hypertrophied muscle bundles and fibrous tissue, whereof the latter is of unclear pathogenesis. Our group has previously reported that flow disturbances lead to formation of fibroelastic tissue through a process called endothelial-to-mesenchymal transition (EndMT) but it is unclear whether the same mechanism exists in the RV.

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Objectives: Very low birthweight (<1500 g, VLBW) infants with severe congenital heart defect (CHD) are at increased risk for perinatal and operative mortality. This study aims to describe morbidity, long-term mortality and neuro-developmental outcome in early childhood in VLBW infants who received cardiac surgery for severe CHD within 1 year after birth.

Methods: Monocentric observational study on VLBW infants with severe CHD born between 2008 and 2017.

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Article Synopsis
  • Acute kidney injury (AKI) is a common issue after neonatal aortic arch repair, with a study comparing two methods: deep hypothermic circulatory arrest (DHCA) and moderate hypothermia with distal aortic perfusion (MHDP).
  • In a total of 125 neonates studied, 54.4% experienced AKI, predominantly stage 1, but higher stages were more frequent in those who underwent DHCA than MHDP.
  • The findings suggest that while mild AKI is common, MHDP is linked to lower rates of moderate and severe AKI, with early mortality rates not showing a significant difference between the two methods.
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Prematurity is a risk factor for adverse outcomes after arterial switch operation in newborns with D-TGA (D-TGA). In this study, we sought to investigate the impact of prematurity on postnatal and perioperative clinical management, morbidity, and mortality during hospitalization in neonates with simple and complex D-TGA who received arterial switch operation (ASO). Monocentric retrospective analysis of 100 newborns with D-TGA.

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