Publications by authors named "Mi Yao Hu"
Occult nodal spread and metastatic disease require longstanding imaging and biochemical assessments for thyroid cancer, a disease that has a propensity for diffuse, small-volume disease. We have developed a Cu-labeled platelet-derived growth factor receptor α (PDGFRA) antibody for immuno-PET of PDGFRA in metastatic papillary thyroid cancer (PTC). The present work describes the discovery of small cyclic PDGFRA-targeting peptides, their binding features, and radiolabeling with positron emitter gallium-68 (Ga) for characterization in thyroid cancer models.
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- HSV-1 is a virus that can hide in our bodies and come back later, making it hard to treat with medicine because it doesn’t act like a regular virus all the time.
- Scientists believe how the virus hides and returns has a lot to do with something called epigenetics, which involves changes in how genes are used.
- Some recent studies suggest that the viruses and our cells work differently when it comes to epigenetics, which might help researchers find new ways to make medicine that can stop the virus.
During latent infections with herpes simplex virus 1 (HSV-1), viral transcription is restricted and the genomes are mostly maintained in silenced chromatin, whereas in lytically infected cells all viral genes are transcribed and the genomes are dynamically chromatinized. Histones in the viral chromatin bear markers of silenced chromatin at early times in lytic infection or of active transcription at later times. The virion protein VP16 activates transcription of the immediate-early (IE) genes by recruiting transcription activators and chromatin remodelers to their promoters.
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