Publications by authors named "Mi Rin Lee"

Article Synopsis
  • Adipose tissue lipolysis, the breakdown of fat, is controlled by a signaling pathway involving cAMP and protein kinase A (PKA), which targets a protein called PAK4 for degradation.
  • Mice with higher levels of PAK4 in their fat tissue show reduced fat breakdown and increased obesity, while mice lacking PAK4 or treated with a PAK4 inhibitor lose weight and improve insulin sensitivity.
  • PAK4 interferes with lipolysis by phosphorylating and inhibiting the action of key proteins (FABP4 and HSL) involved in fat metabolism, with elevated PAK4 levels linked to obesity in humans, suggesting that targeting PAK4 could be a potential obesity treatment.
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Cephalic arch stenosis (CAS) is critical point to maintain functional arteriovenous fistula (AVF) in patients undergoing hemodialysis with brachio-cephalic AVFs. In this study, we aimed to determine the effectiveness of dual outflow (cephalic and basilic veins) as a surgical method to prevent CAS. Between July 2016 and December 2019, 369 patients underwent upper arm AVF creation.

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This study aimed at developing a fully automatic technique for right lobe graft weight estimation using deep learning algorithms. The proposed method consists of segmentation of the full liver region from computed tomography (CT) images, classification of the entire liver region into the right and left lobes, and estimation of the right lobe graft weight from the CT-measured right lobe graft volume using a volume-to-weight conversion formula. The first two steps were performed with a transformer-based deep learning model.

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Purpose: Precise estimation of the standard liver volume (SLV) is crucial in decision making regarding major hepatectomy and living donor liver transplantation. This study aimed to propose an accurate and efficient formula for estimating the SLV in the Korean population.

Methods: We created a regression model for SLV estimation using a data set of 230 Korean patients with healthy livers.

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Article Synopsis
  • PAK4 is an oncogenic protein that plays a significant role in liver injury caused by ischemia/reperfusion (I/R), making it a potential target for anticancer therapy.
  • Research using Pak4 knockout mice revealed that deleting PAK4 in liver cells reduced liver damage and inflammation during I/R injury, while overexpressing it worsened the condition.
  • PAK4 was found to inhibit the antioxidant protein Nrf2, and inhibiting PAK4 showed protective effects against liver injury, suggesting that targeting PAK4 could be a beneficial strategy for treatment.
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Background: An impalement injury of the oral cavity is a common traumatic injury in children. In most cases, it is not accompanied by sequelae, but if foreign body residues are not found due to a minor injury, they may result in inflammatory responses and delayed vascular injuries in the surrounding tissues. Without early diagnosis and appropriate initial management, residual foreign bodies can cause serious complications and even mortality in some cases.

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Introduction: Although the clinical significance of type II endoleaks remain controversial, management strategies continue to expand. The laparoscopic approach is a minimally invasive method for persistent type II endoleak repair after endovascular aneurysm repair.

Patient Concerns: A 70 - year - old male patient with a history of endovascular aneurysm repair with left internal iliac artery embolization presented with persistent type II endoleak from the lumbar arteries 2 years ago.

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Nonalcoholic fatty liver disease (NAFLD) is caused by the hepatic accumulation of saturated fatty acids involving the ER stress mechanism. Secretion of apo lipid carrier proteins and their binding to hepatic TG and cholesterol are affected by ER stress. This study was designed to identify ER stress regulators with potential effects against hepatic lipid accumulation.

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In this study we examined the inhibition of hepatic dyslipidemia by Eucommia ulmoides extract (EUE). Using a screening assay for BAX inhibition we determined that EUE regulates BAX-induced cell death. Among various cell death stimuli tested EUE regulated palmitate-induced cell death, which involves lysosomal BAX translocation.

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Eucommia ulmoides Oliver is a natural product widely used as a dietary supplement and medicinal plant. Here, we examined the potential regulatory effects of Eucommia ulmoides Oliver extracts (EUE) on hepatic dyslipidemia and its related mechanisms by in vitro and in vivo studies. EUE and its two active constituents, aucubin and geniposide, inhibited palmitate-induced endoplasmic reticulum (ER) stress, reducing hepatic lipid accumulation through secretion of apolipoprotein B and associated triglycerides and cholesterol in human HepG2 hepatocytes.

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The anti-apoptotic protein Bax inhibitor-1 (BI-1) is a regulator of apoptosis linked to endoplasmic reticulum (ER) stress. It has been hypothesized that BI-1 protects against neuron degenerative diseases. In this study, BI-1⁻/⁻ mice showed increased vulnerability to chronic mild stress accompanied by alterations in the size and morphology of the hippocampi, enhanced ROS accumulation and an ER stress response compared with BI-1⁺/⁺ mice.

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Article Synopsis
  • The study focuses on developing a quick and efficient method to measure phenylbutyric acid (PBA) and its metabolite, phenylacetic acid (PAA), which are important in managing endoplasmic reticulum (ER) stress linked to various diseases.
  • Using liquid chromatography-tandem mass spectrometry (LC-MS/MS), the researchers achieved accurate detections with a short analysis time of 15 minutes.
  • Findings showed significant differences in the distribution of PBA and PAA across various tissues in mice after injection, indicating higher concentrations in plasma compared to tissues, which could have implications for understanding their roles in human health.
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