Development and validation of a risk prediction model for feeding intolerance in neurocritical patients with enteral nutrition.

Background: This study collects and analyzes clinical data on enteral nutrition therapy in neurocritical patients, develops and validates a feeding intolerance (FI) risk prediction model, and provides a theoretical basis for screening patients with high risk of feeding intolerance (FI) and delivering personalized care.

Methods: A convenience sampling method was employed to select 300 patients who were admitted to a tertiary hospital in China for early enteral nutrition therapy in the neurointensive care unit between April 2022 and December 2022. Independent risk factors for FI were identified using univariate and logistic regression analyses.

Development and validation of a risk prognostic model based on the infection phenotype for stomach adenocarcinoma.

Background: Stomach adenocarcinoma (STAD) is one of the most common malignancies. Infection of helicobacter pylori () is a major risk factor that leads to the development of STAD. This study constructed a risk model based on the -related macrophages for predicting STAD prognosis.

Integrating UPLC-Q-Exactive Orbitrap/MS, network pharmacology and experimental validation to reveal the potential mechanism of Tibetan medicine Rhodiola granules in improving myocardial ischemia-reperfusion injury.

Ethnopharmacology Relevance: Rhodiola granules (RG) is a traditional Tibetan medicine prescription that can be used to improve the symptoms of ischemia and hypoxia in cardiovascular and cerebrovascular diseases. However, there is no report on its use to improve myocardial ischemia/reperfusion (I/R) injury, and its potential active ingredients and mechanism against myocardial ischemia/reperfusion (I/R) injury remain unclear.

Aim Of The Study: This study aimed to reveal the potential bioactive components and underlying pharmacological mechanisms of RG in improving myocardial I/R injury through a comprehensive strategy.

A nomogram prediction model for early death in patients with persistent pulmonary hypertension of the newborn.

Background: Persistent pulmonary hypertension of the newborn (PPHN) is a major lethal disorder in neonates that leads to an extremely high mortality rate. Thus, the early identification of adverse outcomes in PPHN is critical for clinical practice. This research attempted to develop a nomogram prediction system for assessing the mortality of newborns with PPHN.

An In Vitro Dissolution Determination of Multi-Index Components in Tibetan Medicine Rhodiola Granules.

The composition of the Tibetan medicine Rhodiola granules (RG) is complex, and the overall quality of RG is difficult to determine. Therefore, establishing a method to determine the multi-component in vitro dissolution of RG is of great significance for quality control. This study uses the second paddle method of the fourth general rule 0931 from the Chinese Pharmacopoeia (2020 edition), compliant with apparatus 2 of the United States Pharmacopeia (USP).

Clinical significance of SPOCK2 expression signature for high-grade serous ovarian cancer patients.

SPOCK2 is a member of the SPOCK family, a 424-amino acid protein that binds to glycosaminoglycans to form proteoglycans. The purpose of this study was to explore expression profile of SPOCK2, and evaluate prognostic potential and its correlation with immune infiltration in high-grade serous ovarian cancer (HGSOC). Expression of SPOCK2 mRNA and protein between normal and tumor tissues were analyzed using the Cancer Genome Atlas database (TCGA), Gene Expression Omnibus (GEO), Clinical Proteomic Tumor Analysis Consortium (CPTAC), and the Human Protein Atlas (HPA) databases.

Experimental demonstration of wave-front coded imaging with a very low response of the modulation transfer function at the Nyquist frequency.

Wave-front coding (WFC) is a well-known technique that can be used to extend the depth of field (DOF) of incoherent imaging systems. The phase masks make the optical transfer function drop significantly, and digital restoration must be used to obtain a clear image with a largely extended DOF. According to the existing literature, in order to obtain satisfactory restoration results, the optical modulation transfer function (MTF) at the Nyquist frequency is required to be bigger than 0.

Hydroxycinnamoylmalated flavone C-glycosides from Lemna japonica.

Three previously undescribed flavone C-glycosides (1-3), along with seven known ones (4-10), were isolated and characterized from the smallest flowering aquatic plant, Lemna japonica. On the basis of spectroscopic analysis and alkaline hydrolysis, compounds 1-3 were identified to be luteolin 6-C-(2″-O-trans-caffeoyl-d-malate)-β-glucoside (1), apigenin 6-C-(2″-O-trans-caffeoyl-d-malate)-β-glucoside (2), and luteolin 6-C-(2″-O-trans-coumaroyl-d-malate)-β-glucoside (3). Compounds 1-3 are characteristic of a trans-coumaroyl-d-malate or trans-caffeoyl-d-malate linked to C-2″ of the glucose, which was reported for the first time.

The Biological Effects of Dickkopf1 on Small Cell Lung Cancer Cells and Bone Metastasis.

The bone is among the most common sites of metastasis in patients with lung cancer. Over 30%-40% of lung cancers can develop bone metastasis, and no effective therapeutic methods exist in clinic cases. Wnt/β-catenin signaling and Dickkopf1 (DKK1) play important roles in the progression of lung cancer, which preferentially metastasizes to the skeleton.

BN-coated Ca(1-x)Sr(x)S:Eu solid-solution nanowires with tunable red light emission.

We report on the controlled growth of novel BN-coated Ca(1-x)Sr(x)S:Eu nanowires via a solid-liquid-solid process. The Ca(1-x)Sr(x)S solid solution forms as one-dimensional nanowires and has been coated with homogeneous protective BN nanolayers. The structure and luminescence properties of this new nanocomposite have been systematically investigated.

Porous boron nitride with a high surface area: hydrogen storage and water treatment.

We report on the synthesis of high-quality microporous/mesoporous BN material via a facile two-step approach. An extremely high surface area of 1687 m(2) g(-1) and a large pore volume of 0.99 cm(3) g(-1) have been observed in the synthesized BN porous whiskers.