A novel synergistic covalence and complexation bridging strategy based on multi-functional biomass-derived aldehydes and Al(III) for engineering high-quality eco-leather.

To get rid of the chrome pollution faced by the leather industry, we explored a novel engineering high-quality eco-leather technology based on the synergistic interactions between biomass-based aldehydes and Al(III). Firstly, dialdehyde xanthan gum (DXG) was prepared to covalently crosslink with the collagen fibers (CFs) via Schiff-base linkages under alkaline conditions, endowing the leather with a shrinkage temperature (Ts) of 80 °C and opening channels for the subsequent penetration of Al species (AL). Secondly, and for this latter purpose, the DXG-tanned leather was acidified to release part of the DXG from the leather according to the dynamic nature of the Schiff-base.

Green and sustainable 'Al-Zr-oligosaccharides' tanning agents from the simultaneous depolymerization and oxidation of waste paper.

Developing chrome-free and sustainable tanning agents is extremely important to the sustainability of the leather industry. Herein, we have synthesized an Al-Zr-oligosaccharides tanning agent via a simultaneous degradation and oxidation of cellulose in waste paper. The influence of the temperature and the concentrations of AlCl and HO during the synthesis were thoroughly investigated on the properties of the tanning agent and the leather produced.

Mitolysosome exocytosis, a mitophagy-independent mitochondrial quality control in flunarizine-induced parkinsonism-like symptoms.

Mitochondrial quality control plays an important role in maintaining mitochondrial homeostasis and function. Disruption of mitochondrial quality control degrades brain function. We found that flunarizine (FNZ), a drug whose chronic use causes parkinsonism, led to a parkinsonism-like motor dysfunction in mice.

Association Between Extracellular Superoxide Dismutase Activity and 1-Year All-Cause Mortality in Patients With Acute Exacerbations of Chronic Obstructive Pulmonary Disease: A Prospective Cohort Study.

Background And Objectives: Accumulating evidence suggests that oxidative stress is involved in the development of chronic obstructive pulmonary disease (COPD) and its progression. Activity of extracellular superoxide dismutase (ecSOD), the only extracellular enzyme eliminating superoxide radicals, has been reported to decline in acute exacerbations of COPD (AECOPD). However, the association between serum ecSOD activity and 1-year all-cause mortality in AECOPD patients remains unclear.

Biomass-related PM2.5 induces mitochondrial fragmentation and dysfunction in human airway epithelial cells.

The use of biomass for cooking and heating is considered an important factor associated with chronic obstructive pulmonary disease (COPD), but few studies have previously addressed its underlying mechanisms. Therefore, this research aimed to evaluate the effects of biomass-related PM (BRPM) exposure on 16HBE human airway epithelial cells and in mice with regard to mitochondrial dysfunction. Our study indicated that BRPM exposure of 16HBE cells resulted in mitochondrial dysfunction, including decreased mitochondrial membrane potential, increased expression of fission proteins-phospho-DRP1, increased mitochondrial ROS (mtROS), and decreased levels of ATP.

Changes in the gut microbiome and metabolome in a rat model of pulmonary arterial hypertension.

The gut microbiota is widely considered to be involved in several diseases, including atherosclerosis, obesity, chronic obstructive pulmonary disease (COPD) and pulmonary arterial hypertension (PAH). This study aimed to determine if changes in the gut microbiome and metabolome play a major role in the early pathogenesis of PAH. Male Wistar rats were injected with monocrotaline (MCT) (55 mg/kg) at day 1 and injected with calcium-sensing receptor (CaSR) antagonist NPS2143 (4.

Analysis and Construction of a Competitive Endogenous RNA Regulatory Network of Baicalin-Induced Apoptosis in Human Osteosarcoma Cells.

Background: Baicalin is an extract from the traditional Chinese herb and has the potential to treat osteosarcoma (OS). However, the transcriptome-level mechanism of baicalin-mediated antitumor effects in OS has not yet been investigated. The aim of this study was to analyze the competitive endogenous RNA (ceRNA) regulatory network involved in baicalin-induced apoptosis of OS cells.

Systematic Understanding of the Mechanism of Baicalin against Gastric Cancer Using Transcriptome Analysis.

Background: Gastric cancer (GC) is the most common type of cancer. It is highly malignant and is characterized by rapid and uncontrolled growth. The antitumour activity of Baicalin was studied in multiple cancers.

A Combined Model of Human iPSC-Derived Liver Organoids and Hepatocytes Reveals Ferroptosis in DGUOK Mutant mtDNA Depletion Syndrome.

Mitochondrial DNA depletion syndrome (MDS) is a group of severe inherited disorders caused by mutations in genes, such as deoxyribonucleoside kinase (DGUOK). A great majority of DGUOK mutant MDS patients develop iron overload progressing to severe liver failure. However, the pathological mechanisms connecting iron overload and hepatic damage remains uncovered.

Selective degradation and oxidation of hemicellulose in corncob to oligosaccharides: From biomass into masking agent for sustainable leather tanning.

Chrome-free metal tanning agent has been considered as eco-friendly in the leather industry. However, extensive crosslinking reactions of metal species on the leather surface restrain their uniform penetration into the hierarchical nanoscale leather matrix. Thus, masking agents with appropriate coordination ability are needed.

Author Correction: Glis1 facilitates induction of pluripotency via an epigenome-metabolome-epigenome signalling cascade.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Glis1 facilitates induction of pluripotency via an epigenome-metabolome-epigenome signalling cascade.

Somatic cell reprogramming provides insight into basic principles of cell fate determination, which remain poorly understood. Here we show that the transcription factor Glis1 induces multi-level epigenetic and metabolic remodelling in stem cells that facilitates the induction of pluripotency. We find that Glis1 enables reprogramming of senescent cells into pluripotent cells and improves genome stability.

Predicting the weld width from high-speed successive images of the weld zone using different machine learning algorithms during laser welding.

The dynamic behavior of the keyhole and molten pool is associated with the quality of weld seam. In this study, an on-line visual monitoring system is devised to photograph the keyhole and molten pool during external magnetic field assisted laser welding on the AISI 2205 duplex stainless steel plates. Seven features are defined to describe the morphology of the keyhole and molten pool.

Long Noncoding RNA COPDA1 Promotes Airway Smooth Muscle Cell Proliferation in Chronic Obstructive Pulmonary Disease.

Abnormal expression of long noncoding RNAs (lncRNAs) has been confirmed to be associated with many diseases, including chronic obstructive pulmonary disease (COPD). To gain better understanding of the mechanism of COPD, we investigated the lncRNA and mRNA profiles in the lung tissue of patients with COPD. According to the analysis, one of the significantly different lncRNAs, COPDA1, might participate in the occurrence and development of COPD.

Polybrene induces neural degeneration by bidirectional Ca influx-dependent mitochondrial and ER-mitochondrial dynamics.

Hexadimethrine bromide (Polybrene) was once used clinically as a heparin neutralizer and has recently found use as a promoter in virus-mediated gene therapy trials and gene transfer in research. However, the potential for tissue-specific toxicity of polybrene at low doses has been ignored so far. Here, we found that after intracerebroventricular (ICV) polybrene injection, mice showed disability of movement accompanied neural death and gliosis in brain, and in human neurons, polybrene induces concentration-dependent neuritic beading and fragmentation.

BNIP3L-dependent mitophagy accounts for mitochondrial clearance during 3 factors-induced somatic cell reprogramming.

Induced pluripotent stem cells (iPSCs) have fewer and immature mitochondria than somatic cells and mainly rely on glycolysis for energy source. During somatic cell reprogramming, somatic mitochondria and other organelles get remodeled. However, events of organelle remodeling and interaction during somatic cell reprogramming have not been extensively explored.

Assessment of metal contamination in the Hun River, China, and evaluation of the fish Zacco platypus and the snail Radix swinhoei as potential biomonitors.

The Hun River is a major tributary of the Liao River in the northeast area of China and provides drinking water for 23 million local residents. This study was designed to assess the severity of metal contamination in the Hun River and the potential use of indigenous organisms (the fish Zacco platypus and the snail Radix swinhoei) as biomonitors of metal contamination. Water, sediment, and the native fish and snails were collected at four sampling sites that differed in their physicochemical characteristics and their contamination levels.

[Mechanisms of Cr (VI) toxicity to fish in aquatic environment: A review].

With increasing consumption and applications of chromium in metallurgy, electroplating, tanning process and stainless steel industry, chromium contamination has become a global environmental problem. In general, Cr(VI) has higher permeability across the cell membrane than Cr(III) and hence is considered more toxic than Cr(III). Oxidative stress could be induced following reactive oxygen species (ROS) normally produced in fish under Cr(VI) exposure due to its variable valences.

Metal Concentrations in Sediment And Biota of the Huludao Coast in Liaodong Bay and Associated Human and Ecological Health Risks.

This study assessed the contamination extent and potential ecological and human health impacts for chromium (Cr), manganese (Mn), nickel (Ni), copper (Cu), zinc (Zn), cadmium (Cd), and lead (Pb) in sediments and indigenous benthic organisms along the coastal area of Huludao, China. We analyzed a total of eight species: two benthic fish species, two bivalves, two snails, and two decapod crustaceans. Cu, Zn, and Cd levels in sediment exceeded the Chinese marine sediment quality criteria.

Srebp-1 Interacts with c-Myc to Enhance Somatic Cell Reprogramming.

Somatic cell reprogramming is accompanied by changes in lipid metabolism. While attempting to dissect the molecular mechanisms of the lipid metabolic switch during reprogramming, we found that overexpression of sterol regulatory element binding protein-1 (Srebp-1), a transcriptional factor required for lipid homeostasis, enhances reprogramming efficiency, while knockdown or pharmaceutical inhibition of Srebp-1 is inhibitory. Srebp-1 overexpression blocks the formation of partially reprogrammed cells, and functions in the early phase of reprogramming.

Expression of interleukin-22 and its significance in the pathogenesis of chronic rhinosinusitis.

In order to explore the role of IL-22 in the pathogenesis of CRS, we observed the expression of IL-22 and associated factors in chronic rhinosinusitis with nasal polyps (CRSwNP) and chronic rhinosinusitis without nasal polyps (CRSsNP). Immunohistochemical staining was applied to detect the expression of IL-22, IL-22R, STAT3, retinoic acid orphan receptor C (RORC) and aryl hydrocarbon recptor (AhR). There was significantly higher expression of IL-22 in CRSsNP than in controls (P<0.

The arsenic content in marketed seafood and associated health risks for the residents of Shandong, China.

Seafood is considered as the main source of arsenic in the human diet. In this study, we quantified the total arsenic content in 200 samples of 22 species collected from eight cities in Shandong, China. Subsequently, we evaluated the health risks associated with seafood consumption for three consumption scenarios based on the quantification of inorganic arsenic in three commonly consumed seafood species.