Publications by authors named "Mezziani S"
Article Synopsis
- Plasmacytoid dendritic cells (pDCs) play a crucial role in initiating immune responses, making them key targets for immunotherapy after cord blood transplantation (CBT).
- A study showed that pDC levels in children who received CBT were significantly higher than in those who received bone marrow transplantation (BMT) and remained elevated for 2 to 9 months post-transplant.
- Despite the potential for stimulating pDCs with Toll-like receptor (TLR) agonists, their ability to produce interferon-alpha (IFN-α) was compromised for up to 9 months after CBT, suggesting limited immunotherapy effectiveness; however, the large functional pDC production from cord blood offers a promising avenue for future
Background And Objective: Intravenous (IV) busulfan (Bu) combined with therapeutic drug monitoring-guided dosing is associated with better event-free survival (EFS), lower transplant-related mortality. But optimal target steady-state concentration (Css) of Bu in children undergoing hematopoietic stem cell transplantation (HSCT) remains unclear. This study aimed to evaluate the relation between Css of Bu and clinical outcomes in children receiving Bu before HSCT.
View Article and Find Full Text PDFBU is a key compound of conditioning regimens in children undergoing hematopoietic SCT (HSCT). Inter-individual differences in BU pharmacokinetics (PKs) might affect BU efficacy and toxicity. As BU is mainly metabolized by glutathione S-transferase (GST), we investigated the relationship between GSTA1, GSTM1 and GSTP1 genotypes with first-dose BU PKs, and the relationship with HSCT outcomes in 69 children receiving myeloablative conditioning regimen.
View Article and Find Full Text PDFReconstitution of maturating and regulatory lymphocyte subsets after cord blood and BMT in children.
Bone Marrow Transplant
March 2013
Some clinical characteristics of cord blood transplantation (CBT) might be explained by specificities in the reconstitution of immune subsets differing by their maturation stage or their implication in GVHD, tolerance or immune responses against tumor or infectious agents. Here, we compare the immune reconstitution of several of these subsets after CBT and BMT. B-cell count recovery was faster after CBT.
View Article and Find Full Text PDFCMV and varicella zoster virus (VZV) are significant causes of morbidity and mortality following umbilical cord blood transplantation (UCBT). However, the kinetics of reconstitution and protective potential of antiviral cell-mediated immune responses following UCBT remain poorly characterized. In this study, the reconstitution of CMV- and VZV-specific T cell responses was assessed using IFN-γ ELISPOT in 28 children who underwent UCBT to treat hematological or inherited disorders.
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