(2-Fluoroallyl)boration of Ketones with (2-Fluoroallyl)boronates.

Efficient routes toward activation of -chlorofluorocyclopropane-derived (2-fluoroallyl)boronates for allylboration of various ketones including functionalized and low-reactive ones were developed. Increasing the boron electrophilicity by the transformation of a boronate moiety into a borinic ester with BuLi/trifluoroacetic anhydride (TFAA) makes (2-fluoroallyl)boration of acetyl arenes/hetarenes and aliphatic ketones possible with high diastereoselectivity. For low-reactive or sterically hindered ketones (e.

New hydrate formation methods in a liquid-gas medium.

Conceptually new methods of hydrate formation are proposed. The first one is based on the shock wave impact on a water-bubble medium. It is shown that the hydrate formation rate in this process is typically very high.

[Specificity of molecular recognition in oligomerization of bacterial L-asparaginases].

Bacterial L-asparaginases, which are widely used in the antitumor therapy, act only as homotetramers, because their active sites are located at the interface between the subunits of the enzyme. Since salt bridges substantially stabilize L-asparaginase tetramers, we have supposed that oligomerization of bacterial L-asparaginase is a high-avidity process. This assumption was proved by bioinformatic and biosensoric methods.

[Oligomerization of L-asparaginase from Erwinia carotovora].

Bacterial L-asparaginases catalyzing hydrolysis of L-asparagine up to L-aspartate and ammonia, are used in medical practice for treatment of acute lymphoblastic leukemia. The long-term therapy with these preparations is accompanied by a number of side effects, which are attributed to glutaminase activity of L-asparaginase. Substrate specificity and activity of L-asparaginases are directly associated with the process of enzyme oligomerization.

[Diagnosis of the obstructed pulmonary abscesses].

Only spot bronchography, and if its results are negative, transthoracal puncture permit a correct diagnosis of blocked or partially blocked pulmonary abscess in 2/3 of cases. This result is of importance for the choice of the treatment strategy in such patients. Use of thin or super-thin needles for puncture helped to do without serious complications and obtain reliable diagnostic information in 90% of cases.

[Feasibility and limitations of the preoperative diagnosis of meningocele].

The paper is concerned with clinical and x-ray analysis, performed in 10 patients (9 women and 1 man) aged 40 to 50, with meningocele, a congenital abnormality. The final diagnosis of this disease was made possible only by means of transthoracic needle biopsy of cerebrospinal fluid, which was effectively performed in 5 patients.

[Roentgeno-morphologic characteristics of the principal forms of pulmonary sequestration].

Basing on roentgeno-morphological correlations, three morphological types of pulmonary sequestration (PS) were singled out: intrapulmonary, intrapleural (peripulmonary) and extrapleural (mediastinal). PS signs on a skiagram can be of two types: spherical and cavitary. Reliable clinicoroentgenological diagnosis of PS is hardly possible and of hypothetical nature.

[Errors and complications of microsurgical autologous transplantation of tissue in trauma].

Possible errors and complications are analyzed basing on the experience with microsurgical autotransplantation of 87 tissue complexes fulfilled in 81 patients with traumas. Various complications were established in 25 out of 82 patients (30.4%).