Comparing transcervical balloon with osmotic dilators for cervical preparation prior to procedural abortion: A noninferiority randomized trial.

Objectives: This study aimed to compare cervical preparation with transcervical balloon to osmotic dilators for second-trimester procedural abortions.

Study Design: We performed an unblinded, randomized, noninferiority trial of people undergoing second-trimester procedural abortion at 18 + 0 to 23 + 6 weeks' gestation. We randomized participants to either overnight osmotic dilators (Dilapan-S) or transcervical balloon (Foley).

Implications and Optimization of Domain Structures in IV-VI High-Entropy Thermoelectric Materials.

High-entropy semiconductors are now an important class of materials widely investigated for thermoelectric applications. Understanding the impact of chemical and structural heterogeneity on transport properties in these compositionally complex systems is essential for thermoelectric design. In this work, we uncover the polar domain structures in the high-entropy PbGeSnSeTe system and assess their impact on thermoelectric properties.

Nanotube Structure of AsPSSe ( = 0, 1).

Single-wall nanotubes of isostructural AsPSSe ( = 0, 1) are grown from solid-state reaction of stoichiometric amounts of the elements. The structure of AsPS was determined using single-crystal X-ray diffraction and refined in space group . The infinite, single-walled AsPS nanotubes have an outer diameter of ≈1.

Can phone surveys be representative in low- and middle-income countries? An application to Myanmar.

For decades, in-person data collection has been the standard modality for nationally and sub-nationally representative socio-economic survey data in low- and middle-income countries. As the COVID-19 pandemic rendered in-person surveys impossible and unethical, the urgent need for rapid monitoring necessitated researchers and statistical agencies to turn to phone surveys. However, apart from pandemic-related factors, a variety of other reasons can render large segments of a population inaccessible for in-person surveys, including political instability, climatic shocks, and remoteness.

Triose Phosphate Isomerase Structure-Based Virtual Screening and In Vitro Biological Activity of Natural Products as Inhibitors.

Cutaneous leishmaniasis (CL) is a public health problem affecting more than 98 countries worldwide. No vaccine is available to prevent the disease, and available medical treatments cause serious side effects. Additionally, treatment failure and parasite resistance have made the development of new drugs against CL necessary.

Multispectral Filter Array Design by Optimal Sphere Packing.

Multispectral imaging (MSI) collects a datacube of spatio-spectral information of a scene. Many acquisition methods for spectral imaging use scanning, preventing its widespread usage for dynamic scenes. On the other hand, the conventional color filter array (CFA) method often used to sample color images has also been extended to snapshot MSI using a Multispectral Filter Array (MSFA), which is a mosaic of selective spectral filters placed over the Focal Plane Array (FPA).

Red Blood Cell Transfusion in Patients With Placenta Accreta Spectrum: A Systematic Review and Meta-analysis.

Objective: To evaluate red blood cell use during delivery in patients with placenta accreta spectrum.

Data Sources: We searched MEDLINE, EMBASE, CINAHL, Cochrane Central, ClinicalTrials.gov, and Scopus for clinical trials and observational studies published between 2000 and 2021 in countries with developed economies.

Submilligram Level of Beetle Antifreeze Proteins Minimize Cold-Induced Cell Swelling and Promote Cell Survival.

Hypothermic (cold) preservation is a limiting factor for successful cell and tissue transplantation where cell swelling (edema) usually develops, impairing cell function. University of Wisconsin (UW) solution, a standard cold preservation solution, contains effective components to suppress hypothermia-induced cell swelling. Antifreeze proteins (AFPs) found in many cold-adapted organisms can prevent cold injury of the organisms.

The ongoing crisis of abortion care education and training in the United States.

Purpose Of Review: The Dobbs vs Jackson case (Dobbs) decided by the Supreme Court of the United States (SCOTUS) in 2022 rescinded the constitutional right to abortion care, resulting in immediate state bans and severe restrictions on abortion care in almost half of the states at the time of submission. This article reviews the current state of abortion education and training as well as available curricula and programmes to support continued training.

Recent Findings: Prior to Dobbs, a national residency-level training programme, the Ryan Residency Training Program, has helped expand abortion care training in residency programs nationally, yet there remained many barriers to incorporating this training into practice, including practice and hospital restrictions.

Modulation of hepatic amyloid precursor protein and lipoprotein receptor-related protein 1 by chronic alcohol intake: Potential link between liver steatosis and amyloid-β.

Heavy alcohol consumption is a known risk factor for various forms of dementia and the development of Alzheimer's disease (AD). In this work, we investigated how intragastric alcohol feeding may alter the liver-to-brain axis to induce and/or promote AD pathology. Four weeks of intragastric alcohol feeding to mice, which causes significant fatty liver (steatosis) and liver injury, caused no changes in AD pathology markers in the brain [amyloid precursor protein (APP), presenilin], except for a decrease in microglial cell number in the cortex of the brain.

Toxicity profiles and protective effects of antifreeze proteins from insect in mammalian models.

Antifreeze proteins (AFPs), found in many cold-adapted organisms, can protect them from cold and freezing damages and have thus been considered as additional protectants in current cold tissue preservation solutions that generally include electrolytes, osmotic agents, colloids and antioxidants, to reduce the loss of tissue viability associated with cold-preservation. Due to the lack of toxicity profile studies on AFPs, their inclusion in cold preservation solutions has been a trial-and-error process limiting the development of AFPs' application in cold preservation. To assess the feasibility of translating the technology of AFPs for mammalian cell cold or cryopreservation, we determined the toxicity profile of two highly active beetle AFPs, DAFP1 and TmAFP, from Dendroides canadensis and Tenebrio molitor in this study.

Mixed methods evaluation of simulation-based training for postpartum hemorrhage management in Guatemala.

Background: To assess if simulation-based training (SBT) of B-Lynch suture and uterine balloon tamponade (UBT) for the management of postpartum hemorrhage (PPH) impacted provider attitudes, practice patterns, and patient management in Guatemala, using a mixed-methods approach.

Methods: We conducted an in-country SBT course on the management of PPH in a governmental teaching hospital in Guatemala City, Guatemala. Participants were OB/GYN providers (n = 39) who had or had not received SBT before.

Association of bilateral oophorectomy and menopause hormone therapy with mild cognitive impairment: the REDLINC X study.

Background: Dementia is a major public health problem. Estrogen is a regulator of the central nervous system and its deficit could be involved in cognitive decline in older women.

Objective: This study aimed to evaluate the association of bilateral oophorectomy, menopause hormone therapy (MHT) and other factors on mild cognitive impairment (MCI).

Compressive temporal imaging using a rolling shutter camera array.

In this work, we present a novel camera array that exploits the electronic rolling shutter to achieve high speed compressive temporal imaging. Traditional compressive temporal imaging makes use of mechanical coded apertures, despite implementation and calibration challenges. Instead, we propose to model the inherent spatial and temporal coding provided by the distinctive rolling shutter sampling from each camera of the array as a compressive temporal imaging system matrix.

Snapshot compressive spectral depth imaging from coded aberrations.

Compressive spectral depth imaging (CSDI) is an emerging technology aiming to reconstruct spectral and depth information of a scene from a limited set of two-dimensional projections. CSDI architectures have conventionally relied on stereo setups that require the acquisition of multiple shots attained via dynamically programmable spatial light modulators (SLM). This work proposes a snapshot CSDI architecture that exploits both phase and amplitude modulation and uses a single image sensor.

Evaluation of fluopyram for management of Meloidogyne ethiopica and migratory nematodes in commercial tomato greenhouses in the Metropolitan Region of Chile.

Background: The nematicidal effects of fluopyram were evaluated for the suppression of Meloidogyne ethiopica and migratory nematodes, Xiphinema americanum s. l., Hemicycliophora spp.

Changing the landscape of obstetric resident education in low- and middle-income countries using simulation-based training.

Objective: To evaluate simulation-based training (SBT) in low- and-middle-income countries (LMIC) and the long-term retention of knowledge and self-efficacy.

Methods: We conducted an SBT course on the management of postpartum hemorrhage (PPH), shoulder dystocia (SD), and maternal cardiac arrest (MCA) in three government teaching hospitals in Guatemala. We evaluated changes in knowledge and self-efficacy using a multiple-choice questionnaire for 46 obstetrics/gynecology residents.

Method to Determine Syringe Silicone Oil Layer Heterogeneity and Investigation of its Impact on Product Particle Counts.

Prefilled syringes (PFSs) are commonly used for parenteral delivery of protein therapeutics. In PFSs, the inner surface of the syringe barrel is typically coated with silicone oil for lubrication. The total amount of silicone oil as well as its distribution can impact syringe functionality and particle formation.

Pesticide Residues and Health Risk Assessment in Tomatoes and Lettuces from Farms of Metropolitan Region Chile.

Over the last years, the detection of pesticide residues in the official food surveillance programs of Chile has been increased, mainly in fresh vegetables such as tomatoes and lettuces. The Metropolitana Region of Chile presents the highest detections in the country. The lack of evaluations of toxicological risks in human health have increased uncertainty of the potential effects of pesticides exposures in the Chilean population.

Coronary Artery Dilation in Children with Febrile Exanthematous Illness without Criteria for Kawasaki Disease.

Background: Coronary dilatation is the most important complication of Kawasaki disease (KD) and, in addition to some clinical characteristics, is common to KD and febrile exanthematous illnesses (FEIs).

Objective: To assess whether children with FEI, who do not meet the criteria for KD, have changes in coronary arteries dimensions.

Methods: Echocardiography was performed within the first two weeks of the disease in patients < 10 years with fever and exanthema without other KD criteria.

Compressive spectral imaging via deformable mirror and colored-mosaic detector.

Compressive Spectral Imaging (CSI) is an emerging technology that aims at reconstructing a spectral image from a limited set of two-dimensional projections. To capture these projections, CSI architectures often combine light dispersive elements with coded apertures or programmable spatial light modulators. This work introduces a novel and compact CSI architecture based on a deformable mirror and a colored-filter detector to produce compressive spatio-spectral projections without the need of a grating or prism.

Evidence of microplastic accumulation in agricultural soils from sewage sludge disposal.

Microplastics are emerging as a steadily increasing environmental threat. Wastewater treatment plants efficiently remove microplastics from sewage, trapping the particles in the sludge and preventing their entrance into aquatic environments. Treatment plants are essentially taking the microplastics out of the waste water and concentrating them in the sludge, however.

Waiting it out: consultation delays prolong in-patient length of stay.

Background: Decreasing delays for hospitalised patients results in improved hospital efficiency, increased quality of care and decreased healthcare expenditures. Delays in subspecialty consultations and procedures can cause increased length of stay due to reasons outside of necessary medical care.

Objective: To quantify, describe and record reasons for delays in consultations and procedures for patients on the general medicine wards.