Publications by authors named "Meydan Ben Ishai"
Background: To report a single center experience with semi-adjustable posterior approach levator plication ('levatorpexy') in patients with congenital ptosis.
Materials And Methods: A retrospective study. All cases who underwent posterior approach levatorpexy for congenital ptosis between the years 2016 to 2022 were included.
Purpose: To describe the prevalence and outcome of motor vehicle accidents-associated ocular injuries.
Methods: A survey of patients who presented to the emergency room at a level 1 trauma center with motor vehicle accidents-associated ocular injuries. A patient questionnaire and review of clinical notes were conducted for all patients.
Purpose: To examine the long-term success rate of pediatric endoscopic DCR surgery via telephone questionnaires, as determined by patients and their parents.
Methods: This is a retrospective cohort study of all patients who underwent DCR surgery at the Schneider Children's Medical Center of Israel between 2010 and 2020. We performed long-term follow-ups to assess the quality of life, surgical complications, and satisfaction with surgical outcomes.
Article Synopsis
- The study evaluated cemiplimab, a PD-1 inhibitor, for treating cutaneous periocular-locally-advanced squamous-cell-carcinoma (POLA-SCC) with orbital invasion.
- Conducted at four medical centers between 2019-2022, it analyzed 13 patients with biopsy-confirmed POLA-SCC and found a 69.2% overall response rate.
- Results showed that a significant portion of patients achieved complete responses, and none required orbital exenteration, suggesting cemiplimab may be a promising treatment option for this condition.
Article Synopsis
- The study aimed to evaluate the foveal microvascular structure in children who had retinopathy of prematurity (ROP) and were treated with diode laser photocoagulation, utilizing optical coherence tomography angiography (OCTA).
- The research involved 17 children with a history of ROP and compared their OCTA results to those of 12 healthy controls, finding significant differences in several parameters.
- Key findings included a smaller foveal avascular zone and lower vascular density in the ROP group, indicating that OCTA can reveal important long-term changes in macular structures for these patients.
Purpose: To establish a model to predict treatment outcome of periocular locally advanced basal cell carcinoma (POLA BCC) based on initial response to treatment with vismodegib (Erivedge), a sonic hedgehog inhibitor.
Design: Subgroup analysis of data from the STEVIE study database.
Methods: Analysis of medical history, treatment protocol, and treatment outcome of POLA BCC tumours in a STEVIE study population of 244 POLA BCC patients treated with ≥1 dose of vismodegib.
Background: Eye trauma is an unfortunate and often preventable cause of vision loss. Confetti cannons are common causes of injury. Awareness of ocular hazards of confetti cannons remains low because of limited reports describing ophthalmic injuries following their use.
View Article and Find Full Text PDFPurpose: To assess the normal healing process of limbal-conjunctival autograft (LCA) after pterygium removal during the early postoperative period using anterior segment optical coherence tomography angiography (OCTA).
Methods: Prospective case series of seven patients undergoing pterygium removal with LCA transplantation procedure, imaged with anterior segment OCTA, and anterior segment colour photos prior to the procedure and on postoperative day (POD) 1, 3, 7 and 30. Revascularization of the graft was analysed quantitatively and qualitatively to estimate patterns of blood vessel growth.
Aflibercept clearance through the drainage system in a rat model.
Int J Retina Vitreous
September 2021
Article Synopsis
- The study investigates the clearance of Aflibercept, an anti-VEGF treatment, from the anterior chamber of the eye in a rat model to understand its impact on intraocular pressure (IOP).
- Following induction of choroidal neovascular lesions, rats received Aflibercept injections and were euthanized at various time intervals for analysis using fluorescence staining.
- Results showed complete clearance of Aflibercept from the anterior chamber angle within 48 hours, suggesting that there is no mechanical obstruction related to elevated IOP in the context of Aflibercept treatment.
Objectives: To evaluate the effect of locally advanced periocular basal cell carcinoma (POLA-BCC) on health-related quality of life (HRQoL) and the benefit of vismodegib treatment among participants in the Safety Events in Vismodegib (STEVIE) trial between 2011 and 2017.
Methods: The STEVIE trial was conducted in patients with BCC (all anatomic locations) who were treated with vismodegib in 28-day cycles. Patients completed the Skindex-16, a validated questionnaire for the analysis symptoms, emotions, and functioning, at baseline, on day 1 of cycle 2, on day 1 of cycle 7, and at the end-of-study visit.
Introduction: To compare the safety and efficacy of the Therapeutic Hyper-CL™ lens versus a standard bandage contact lens (PureVision B&L) for chronic corneal edema.
Methods: Prospective, multicenter, randomized, crossover study. Chronic corneal edema patients were randomized to one of two arms.
Purpose: To evaluate the effect of a single subconjunctival aflibercept injection on formed corneal neovascularization.
Methods: A prospective clinical trial, conducted at a single tertiary medical center. Included were consecutive patients with corneal pathologies complicated by corneal neovascularization, who were candidates for anti-vascular endothelial growth factor treatment at the discretion of a cornea specialist.
Importance: The outcomes of vismodegib treatment in a relatively large cohort of study participants with periocular locally advanced basal cell carcinoma (POLA-BCC) may guide physicians when considering this treatment.
Objective: To report the outcomes of vismodegib treatment in patients with POLA-BCC in the Safety Events in Vismodegib (STEVIE) study.
Design, Setting, And Participants: This post hoc subgroup analysis from the STEVIE single-arm, multicenter, open-label cohort study screened all 1215 participants for ocular or periocular involvement and identified 244 participants with POLA-BCC or metastatic BCC.
A 61-year-old man presented with acute painless optic neuropathy with resultant no light perception in his left eye. Neuro-ophthalmological examination, optical coherence tomography and fluorescein angiography did not reveal the etiology. Since the patient had a cardiac pacemaker, he underwent a CT scan with contrast of the brain and orbits, which was normal.
View Article and Find Full Text PDFBackground: There is scant research on the psychopathology of Israeli soldiers who present to a general hospital emergency department (ED).
Objectives: To assess the psychopathology among a cohort of Israeli soldiers who presented to a general hospital ED for mental health assessment.
Methods: The demographic and clinical characteristics of 124 consecutive soldiers who presented to the ED for psychiatric assessment between January 2008 and September 2012 were reviewed.
Previous studies in several fields of medicine, including general ophthalmology, have revealed a positive results bias, demonstrating an association between the results of a trial and the impact factor (IF) of the journal in which it was published. We hypothesized that randomized clinical studies in pediatric ophthalmology with positive results have a greater chance of publication in journals with a higher IF than those with negative results. We analyzed 174 randomized, controlled trials conducted in the field of pediatric ophthalmology, which were retrieved from PubMed.
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