Publications by authors named "Meuleman S"
Oncolytic viruses show promise in enhancing tumor immunogenicity by releasing immunogenic signals during tumor cell infection and lysis. In this study, we improved the virus-induced tumor immunogenicity of recombinant Semliki Forest virus (rSFV)-based replicon particles by encoding immunogenic cytokines such as C-X-C motif chemokine ligand 10 (CXCL10), FMS-like tyrosine kinase 3 ligand (Flt3L), or interferon-gamma (IFN-ƴ). Real-time imaging and flow cytometry of human cancer cell-based monolayer and spheroid cultures, using LNCaP or PANC-1 cells, revealed effective infection and transgene expression in both models.
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- Scientists studied a type of brain tumor in kids called high-grade glioma that has a special gene mutation in a protein called H3.3.
- They found that this mutation might be causing problems with how DNA is copied during cell division, making it unstable.
- By using lab experiments, they showed that when this mutation is present, it leads to more mistakes in DNA copying, which could help the tumor grow.
Background: Myotonic Dystrophy type 1 (DM1) is primarily a neuromuscular disease but can also have neuropsychological consequences (i.e.cognitive, emotional and behavioural) which can influence daily living and societal participation.
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