Publications by authors named "Mette-Kirstine Christensen"
Article Synopsis
- - The study aimed to compare the effectiveness of high-efficacy disease-modifying therapies (heDMTs) and medium-efficacy disease-modifying therapies (meDMTs) in patients with multiple sclerosis (MS) who have not previously received treatment, focusing on disability worsening and relapse rates.
- - Researchers analyzed data from the Danish Multiple Sclerosis Registry, assessing a total of 388 patients, with findings showing that those on heDMT had significantly lower rates of disability worsening and first relapses compared to those on meDMT over a 4-year period.
- - The conclusion indicates that starting treatment with heDMT is associated with a reduced risk of deterioration in disability and fewer relapses in MS patients, providing Class
Objective: This study compares the new Motor Unit Number Estimation (MUNE) technique, MUNIX, with the more common incremental stimulation MUNE (IS-MUNE) with respect to reproducibility in healthy subjects and as potential biomarker of disease progression in patients with ALS.
Methods: Thirteen ALS patients and 48 control subjects were prospectively investigated - both groups were studied with MUNIX and IS-MUNE applied on the abductor digiti minimi (ADM) muscle. Additional retest was performed on 14 control subjects.
The basolateral amygdaloid complex is a site of origin for zinc-containing pathways in the brain; it is also known for its massive innervation of the medial prefrontal cortex. The presence, and potential neuromodulatory role, of zinc within this fundamental corticolimbic circuit has not been described. For this study, basolateral neurons innervating the medial prefrontal cortex were retrogradely labeled with FluoroGold, and zinc-containing neurons were identified using autometallography to visualize zinc selenium precipitates.
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