Accuracy and potential improvements of surface-guided breast cancer radiotherapy in deep inspiration breath-hold with daily image-guidance.

Radiotherapy of left-sided breast cancer in deep inspiration breath-hold (DIBH) reduces the heart dose. Surface guided radiotherapy (SGRT) can guide the DIBH, but the accuracy is subject to variations in the chest wall position relative to the patient surface.In this study, ten left-sided breast cancer patients received DIBH radiotherapy with tangential fields in 15-18 fractions.

Analysis of cardiac substructure dose in a large, multi-centre danish breast cancer cohort (the DBCG HYPO trial): Trends and predictive modelling.

Background And Purpose: Radiotherapy for breast cancer can increase the risks of heart disease. Patient-specific risk assessment may be improved with the inclusion of doses to cardiac substructures. The purpose of this work was to use automatic segmentation to evaluate substructure doses and develop predictive models for these based on the dose to the whole heart.

Fully automated detection of heart irradiation in cine MV images acquired during breast cancer radiotherapy.

Purpose: To develop robust automated detection of heart irradiation in continuous portal images (cine MV images) of tangential breast cancer treatments.

Methods: Cine MV images of 302 tangential field deliveries were recorded for ten left-sided breast cancer patients receiving deep-inspiration breath-hold radiotherapy. An algorithm for fully automated heart edge detection in cine MV images was developed and tested for all images.

Characterization and radiosensitivity of HPV-related oropharyngeal squamous cell carcinoma patient-derived xenografts.

Oropharyngeal squamous cell carcinomas (OPSCC) are rising rapidly in incidence due to Human Papillomavirus (HPV) and/or tobacco smoking. Prognosis is better for patients with HPV-positive disease, but may also be influenced by tobacco smoking and other factors. There is a need to individualize treatment to minimize morbidity and improve prognosis.

DBCG hypo trial validation of radiotherapy parameters from a national data bank versus manual reporting.

Introduction: The current study evaluates the data quality achievable using a national data bank for reporting radiotherapy parameters relative to the classical manual reporting method of selected parameters.

Methods: The data comparison is based on 1522 Danish patients of the DBCG hypo trial with data stored in the Danish national radiotherapy data bank. In line with standard DBCG trial practice selected parameters were also reported manually to the DBCG database.

Setup error and motion during deep inspiration breath-hold breast radiotherapy measured with continuous portal imaging.

Background: The position and residual motion of the chest wall of breast cancer patients during treatment in deep inspiration breath-hold (DIBH) were investigated.

Material And Methods: The study included 58 left-sided breast cancer patients treated with DIBH three-dimensional (3D) conformal radiotherapy in 15 or 25 fractions. The DIBH levels were monitored using an external marker block placed on the chest, either shifted 5 cm to the right at the level of the xiphoid process (Group 1, 27 consecutive patients) or placed medially on the inferior part of the sternum (Group 2, 31 consecutive patients).

Risk of second primary lung cancer in women after radiotherapy for breast cancer.

Background: Several epidemiological studies have reported increased risks of second lung cancers after breast cancer irradiation. In this study we assessed the effects of the delivered radiation dose to the lung and the risk of second primary lung cancer.

Methods: We conducted a nested case-control study of second lung cancer in a population based cohort of 23,627 early breast cancer patients treated with post-operative radiotherapy from 1982 to 2007.

A model for managing patient booking in a radiotherapy department with differentiated waiting times.

Background: In Denmark, the waiting time from the ready-to-treat date to the first radiotherapy fraction is by national legislation guaranteed not to exceed 4 weeks. This guarantee has now been tightened for some specific diagnoses as it is required that e.g.

[Postoperative radiotherapy treatment of early breast cancer].

Postoperative radiotherapy (RT) is an important part of the multidisciplinary treatment of early breast cancer. Meta-analyses of large randomized trials of RT after lumpectomy and mastectomy have shown that RT reduces the risk of local recurrence with at least 70% and mortality after 15 years with 5%. The effect is most pronounced in patients with a high risk of local recurrence, but is independent of adjuvant systemic treatment.