Publications by authors named "Mette Nilsen"

Metastatic tumors with moderate radiosensitivity account for most cancer-related deaths, highlighting the limitations of current radiotherapy regimens. The xCT-inhibitor sulfasalazine (SAS) sensitizes cancer cells to radiotherapy by blocking cystine uptake the xCT membrane antiporter, and thereby glutathione (GSH) synthesis protecting against radiation-induced oxidative stress. The expression of xCT in multiple tumor types implies it as a target generic to cancer rather than confined to few subtypes.

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Cocrystallized acetonitrile solvent molecules located inside 5.2 A channels in the crystal structure of L-leucyl-L-serine have been replaced by I2 molecules with full retention of the peptide scaffold.

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