Publications by authors named "Mette M Larsen"
Article Synopsis
- Patients with colorectal cancer that has spread to the peritoneum (PM-CRC) have a poor prognosis and respond poorly to chemotherapy.
- The study analyzed tumor samples from 230 patients treated with hyperthermic intraperitoneal chemotherapy (HIPEC) to investigate the molecular characteristics of these tumors, revealing that 27% had BRAF mutations, which were linked to significantly lower survival rates.
- BRAF mutations were associated with specific gene expression changes and immune checkpoint molecules, suggesting that targeting Wnt signaling and these immune checkpoints could provide new treatment options for PM-CRC.
