Publications by authors named "Mette Kenfelt"
Concentrations, Number of Doses, and Formulations of Aluminium Adjuvants in Vaccines: A Systematic Review with Meta-Analysis and Trial Sequential Analysis of Randomized Clinical Trials.
Marija Barbateskovic Sarah Louise Klingenberg Sara Russo Krauss Dezhao Kong Zhangtong Wu Mette Kenfelt
Vaccines (Basel)
November 2023
Article Synopsis
- Aluminium adjuvants are added to vaccines to enhance their effectiveness, and researchers evaluated the impacts of various types, concentrations, doses, and sizes of these adjuvants through a systematic review and analysis of clinical trials.
- The study included 10 randomized clinical trials involving healthy participants and found no significant differences in serious adverse events, all-cause mortality, or non-serious adverse events based on the data analyzed.
- The overall certainty of evidence was low to very low, and important aspects like quality of life or disease development among participants were not reported, leaving the benefits and risks of different aluminium adjuvants uncertain.
Objectives: To assess the benefits and harms of aluminium adjuvants versus placebo or no intervention in randomised clinical trials in relation to human vaccine development.
Design: Systematic review with meta-analysis and trial sequential analysis assessing the certainty of evidence with Grading of Recommendations Assessment, Development and Evaluation (GRADE).
Data Sources: We searched CENTRAL, MEDLINE, Embase, LILACS, BIOSIS, Science Citation Index Expanded and Conference Proceedings Citation Index-Science until 29 June 2021, and Chinese databases until September 2021.