Publications by authors named "Metin Unlu"
Clinical Relevance: Endonasal dacryocystorhinostomy (EN-DCR) is one of the preferred interventions for occlusion of the nasolacrimal drainage system. Understanding the bulbar conjunctival changes that occur after EN-DCR surgery will provide better insight into the effect of this procedure on visual quality and patient comfort.
Background: This study aimed to evaluate visual quality and bulbar conjunctival cytologic changes using in vivo confocal microscopy and corneal topography in patients with epiphora resulting from nasolacrimal duct obstruction after EN-DCR.
Purpose: We evaluated the surgical outcomes and management of complications associated with the minimally invasive conjunctivodacryocystorhinostomy using the StopLoss Jones (SLJT) tube of proximal lacrimal canal obstruction.
Methods: The study retrospectively included 22 eyes of 15 patients who underwent SLJT for proximal canalicular obstruction. Age, gender, follow-up duration, etiology of canalicular obstruction, previous surgery, tube size, complications, and the need for additional surgical intervention were assessed.
Objective: To compare the results of one-step surgery (OSS) and two-step surgery (TSS) in the surgical management of eyelid basal cell carcinomas (BCC).
Method: A total of 43 eyes of 43 patients were included. OSS was applied to 22 of these patients, while TSS was applied to 21 patients.
Article Synopsis
- The study aimed to assess the choroidal vascular parameters in keratoconus (KC) patients and their relationship to eye topography.
- Researchers analyzed 90 KC patients grouped by severity and compared them to 29 patients without KC, focusing on choroidal microvascular density and vascularity indices.
- Results indicated a decrease in specific retinal nerve fiber thickness and choroidal vascularity in advanced KC patients, along with a weak negative correlation between choroidal vascularity and keratometry measurements.
Article Synopsis
- The study aimed to explore changes in the peripapillary choroidal vascular structure in patients with thyroid orbitopathy (TO), comparing those with active and inactive forms of the condition to healthy controls.
- It found significant reductions in various choroidal vascular indices in both active and inactive TO patients compared to controls, particularly noted in the nasal and temporal areas.
- The findings suggest that the horizontal areas of the choroidal structure are more sensitive indicators of changes due to TO, with the inferior quadrant being the first affected in active cases.
Article Synopsis
- The study aimed to examine the superficial and deep vascular characteristics of the optic disc in patients with retrobulbar optic neuritis using optical coherence tomography angiography (OCT-A).
- Nineteen patients with unilateral non-infectious retrobulbar neuritis were analyzed, comparing the affected eyes to healthy contralateral eyes, with various optic nerve parameters assessed through OCT-A.
- Results showed significant decreases in certain superficial capillary densities in eyes with optic neuritis, while other parameters such as PPCMv density remained unchanged.
Article Synopsis
- * Results showed decreased peripapillary vascular density and lamina cribrosa thickness (LCT) in TO patients, particularly those with dysthyroid optic neuropathy (DON), but retinal nerve fiber layer thickness (RNFLT) did not show significant differences among groups.
- * IV MTP treatment improved LCT and best-corrected visual acuity in patients, while other measured factors like intraocular pressure and proptosis also decreased, suggesting beneficial effects of the treatment
Purpose: The purpose of the study was to investigate the parapapillary choroidal microvasculature in thyroid eye disease (TED) using optical coherence tomography angiography (OCTA).
Methods: Only one eye of each subject was included in the study. Patients with TED and controls were included in the study.
Objective: Basal cell carcinomas (BCC) mostly originate from the head and neck region. Main goal in BCC treatment is to achieve both aesthetic and functional results while observing the principles of tumor surgery. We report our experience regarding the clinical, histopathological features and surgical treatment results of head and neck basal cell carcinomas in the light of the literature.
View Article and Find Full Text PDFPurpose: In the present study, antifungal activity of ozonated olive oil (OZO) and ozonated distilled water (ODW) in the treatment of experimentally induced keratitis with in rabbits were investigated.
Methods: The Groups were composed of as 1, 2, 3, 4, 5, 7 (n = 5 rabbits, 10 eyes/in each group) and Group 6 (n = 10 rabbits, 20 eyes/in the group). Fourty-eight hours after inoculation; Group 1 received fluconazle (FLU)+OZO drops, Group 2 received FLU drop, Group 3 received OZO drop, Group 4 received FLU+ODW drops, Group 5 received ODW drop, Group 6 (infected control group) and Group 7 received PBS drop (negative control group).
Anterior ischemic optic neuropathy and cilioretinal artery occlusion secondary to polyarteritis nodosa: A case report.
Photodiagnosis Photodyn Ther
June 2021
Introduction: Polyarteritis nodosa is a systemic vasculitis characterized by necrotizing inflammatory lesions affecting the middle and small arteries.
Case Presentation: A 23-year-old male presented to our ophthalmology clinic with a 1-day history of sudden vision loss in his left eye. Posterior segment examination the left eye showed optic disc borders were faint, hyperemic and fluffy with cilioretinal artery occlusion signs present.
Objectives: To investigate the correlation between the clinical grading of the severity of meibomian gland dysfunction (MGD) and meibomian gland area (MGA) loss detected using Sirius meibography in the upper and lower eyelids and to correlate these parameters with dry eye signs and symptoms.
Methods: One hundred thirty eyes of 130 volunteer patients were enrolled. Meibomian gland dysfunction was defined as the presence of signs consistent with meibomian gland terminal duct obstruction and categorized between grades 1 and 4.
Article Synopsis
- This study aimed to evaluate the safety and effectiveness of using stem cells derived from adipose tissue (ADMSC) for patients with optic nerve diseases through a procedure called suprachoroidal implantation.
- The research involved four patients with optic atrophy, who were monitored over six months for changes in visual acuity and other eye examinations.
- Results showed that all patients saw improvements in their vision and eye health without any complications, suggesting that this stem cell treatment could be a promising option for conditions lacking curative treatments.
This prospective clinical case series aimed to investigate the safety and efficacy of suprachoroidal adipose tissue-derived mesenchymal stem cell (ADMSC) implantation in patients with dry-type age-related macular degeneration (AMD) and Stargardt's macular dystrophy (SMD). This study included four patients with advanced-stage dry-type AMD and four patients with SMD who underwent suprachoroidal implantation of ADMSCs. The best-corrected visual acuity (BCVA) in the study was 20/200.
View Article and Find Full Text PDFObjectives: To assess the effects of anti-vascular endothelial growth factor (VEGF) drugs on retinal pigment epithelium cell culture.
Materials And Methods: Aflibercept (0.5 mg/mL), bevacizumab (0.
Ocular complications of severe corneal abrasions after cosmetic blepharopigmentation.
J Cosmet Laser Ther
January 2020
A 53-year-old woman with hemiparesis and poor dexterity, underwent cosmetic blepharopigmentation on the both upper eyelids in the dermatology clinic of a private hospital. She was not asked for any information on her medical history and no informed consent was obtained and the procedure was performed without any protective ocular shields. The patient experienced severe lacrimation, discomfort, and increased sensitivity to light during and after the procedure.
View Article and Find Full Text PDFPurpose: To define the alterations in retinal vessel diameter in Parkinson's disease (PD) by optical coherence tomography (OCT).
Methods: This is a case-control study including 41 eyes of 41 patients with diagnosis of PD and 35 eyes of 35 age- and sex-matched control subjects. All subjects underwent complete neurological and ophthalmological examinations before measurements.
A 25-year-old woman underwent diode laser application on the both upper eyelids in the dermatology department of a private hospital to obtain a cosmetic healing of the reddish look on her eyelids without any protective lenses. The patient experienced severe uveitis, atonic pupils, raised intraocular pressure, and increased sensitivity to light in her eyes on the following day of the procedure. Topical steroids and pressure-lowering agents were able to treat the acute uveitis and glaucoma, unfortunately the patient suffered from irreversible atonic and atrophic pupils and photosensitivity.
View Article and Find Full Text PDFPurpose: There have been ongoing clinical trials of therapeutic agents in Huntington's disease (HD) which requires development of reliable biomarkers of disease progression. There have been studies in the literature with conflicting results on the involvement of retina in HD, and up to date there is not a study evaluating the single retinal layers in HD. We aimed to evaluate the specific retinal changes in HD and their usability as potential disease progression markers.
View Article and Find Full Text PDFTo assess the correlation between functional and anatomical evaluations with multifocal electroretinography (mfERG) and spectral-domain optical coherence tomography (SD-OCT) in patients with Parkinson's disease (PD). This cross-sectional study involved 116 eyes of 58 patients with PD and 30 age- and sex-matched control subjects. All study participants underwent a comprehensive neuro-ophthalmic examination, retinal single-layer thicknesses and volumes, and peripapillary retinal nerve fiber layer (pRNFL) measurements with SD-OCT, and the patients' mfERG recordings were evaluated.
View Article and Find Full Text PDFBackground: Differentiating Parkinson disease (PD) from progressive supranuclear palsy (PSP) can be challenging early in the clinical course. The aim of our study was to see if specific retinal changes could serve as a distinguishing feature.
Methods: We used spectral domain optical coherence tomography (SD-OCT) with automatic segmentation to measure peripapillary nerve fiber layer thickness and the thickness and volume of retinal layers at the macula.
Purpose: To compare corneal wetting performances of different dispersive ophthalmic viscosurgical devices.
Methods: Three different types of dispersive ophthalmic viscosurgical devices, hydroxypropyl methylcellulose %2 (HPMC), sodium hyaluronate %3-sodium chondroitin sulphate %4 (HACS), and sodium hyaluronate %3 (HA), were applied on corneal surfaces of 10 healthy volunteer subjects repeatedly at 3 different time points. Corneal wetting properties of the ophthalmic viscosurgical devices were compared qualitatively and quantitatively by anterior segment optical coherence tomography for 30 minutes.
Background: The aim of the study is to test whether use of autologous serum eye-drops can provide earlier epithelial healing following the application of photorefractive keratectomy.
Method: Sixty patients (60 eyes) underwent photorefractive keratectomy for myopia. Thirty eyes received autologous serum drops (Study group) while 30 eyes received conventional artificial tears (Control group) after photorefractive keratectomy.
Aim: To evaluate the retinal vessel diameters in patients with migraine by optical coherence tomography (OCT).
Methods: In this cross-sectional study, 124 eyes of 62 patients with a diagnosis of unilateral migraine during attack-free period and 42 age- and sex-matched control subjects were included. Migraine patients were divided into the ≤2 migraine attacks per month group and the ≥5 migraine attacks per month group.
Purpose: To evaluate the effect of fluorescein angiography on retinal vessel diameter with Optical Coherence Tomography (OCT).
Methods: In this cross-sectional study, a total of 81 eyes of 81 patients who were performed fluorescein angiography (FA) procedure were included. Retinal vessels were examined with the Spectral-domain OCT at baseline and immediately after FA procedure.