PO-22 - Thrombodynamics test for analysis of hemostasis in patients with malignant tumors and predicting thrombotic complications.

Introduction: Close correlation between oncologic diseases and blood coagulation disturbances dictates a necessity of prognosis of the main disease course and contemporary prevention of the thrombotic complications revealed. For this purpose, the global test for the hemostasis system assessment was used to reveal bleeding and thrombogenesis risks - "Thrombodynamics" (TD) allowing analysis in the real time of the thrombogenesis parameters in conditions the most resembling the natural functioning of the blood coagulation system. Parameters of TD test which enable differentiation between hyper-, normo- and hypocoagulation include the speed of the blood clot growth (the time of growth delay, initial and stationary blood clot growth) as well as the physical features of the clot (size and density).

[Investigation of lymphocytes activation using a method of coherent phase microscopy].

Investigation of initial stages of T-lymphocytes activation was performed by coherent phase microscopy (CPM) based on the measurements of phase thickness and diameter of the cell and its organelles. Lymphocytes where activated in two ways: by addition of 2 10-6 g/ml phytohemagglutinin (PHA) and with He-Ne laser (lambda = 633 nm, 10-3 W) radiation. It was shown that phase thickness is proportional to refractivity (difference between refractive indices of an object and the surrounding medium) and geometrical thickness.

[Computer morphometry of lymphocytes in the diagnosis of chronic transplant nephropathy].

Aim: to assess the role of immunological mechanisms in the development and progression of chronic transplant nephropathy (CTN) and the prognostic value of rapid computer morphometry of lymphocytes in predicting the risk of renal allograft rejection.

Subjects And Methods: Thirty-seven renal graft recipients (29 males and 8 females; mean age 35.9 +/- 2.

[Morphofunctional characteristics of neutrophils in patients with autoimmune thyroiditis].

Aim: To study morphofunctional status of neutrophilic polymorphonuclear leukocytes (NPNL) in patients with chronic autoimmune thyroiditis (CAIT).

Material And Methods: The morphofunctional status of NPNL was investigated with vital computer phasic morphometry (CPM) in 25 patients (24 females and 1 male, mean age 45.4 +/- 3.