The protection of the myocardium by amifostine against mitoxantrone-induced acute cardiotoxicity in rats.

Objective: Amifostine (AMI) has been used for the prevention of doxorubicin-induced cardiotoxicity in several experimental and a few clinical studies. The aim of this study was to investigate the effects of AMI on lipid peroxidation, protective enzymes, and mitoxantrone (MITO)-induced acute cardiotoxicity in the rat heart using biochemical tests and histopathological examinations.

Methods: Thirty-six rats were divided into six groups (n=6 in each).