Associations of Plasma Neurofilament Light Levels With Brain Microstructure and Macrostructure and Cognition in the Community-Based Rhineland Study.

Background And Objectives: Plasma neurofilament light chain (NfL) level is a sensitive yet aspecific marker of neurodegeneration. Its neuroanatomical and functional correlates in the general population are not fully elucidated. We thus assessed how brain's macrostructures and microstructures and cognitive function are related to plasma NfL levels in cognitively unimpaired adults over a wide age range.