[First experience with robotic-assisted colorectal surgery].

Robot-assisted surgery has been available at the National Institute of Oncology since 2022. We report on the most important parameters of the colorectal robot-assisted surgery of the first 191 patients. Robotically assisted rectal surgery was compared with our previous laparoscopic and open surgical activities.

Ferroelectric hydrogels from amino acids and oleic acid.

Ferroelectric bio-based materials with a high water content (≈90 wt %) were not previously developed. Here, we develop hydrogels containing ≈90 wt % water, amino acids (lysine and arginine) and oleic acid. The NH and CH groups of lysine hydrogen bond water, as shown by attenuated total reflectance-Fourier transform infrared spectroscopy, yielding electrically conductive solutions.

Cryo-EM structures of a bathy phytochrome histidine kinase reveal a unique light-dependent activation mechanism.

Phytochromes are photoreceptor proteins in plants, fungi, and bacteria. They can adopt two photochromic states with differential biochemical responses. The structural changes transducing the signal from the chromophore to the biochemical output modules are poorly understood due to challenges in capturing structures of the dynamic, full-length protein.

Asymmetric changes in foot anthropometry with pregnancy may be related to onset of lower limb and low back pain.

Introduction: Fifty percent of pregnant females experience pain with 20% reporting long-term pain post-partum. Pregnant females undergo changes in foot anthropometry, lower extremity alignment, and joint laxity. It is unknown if asymmetric alterations may be related to development of pain.

3D-printed sheet jet for stable megahertz liquid sample delivery at X-ray free-electron lasers.

X-ray free-electron lasers (XFELs) can probe chemical and biological reactions as they unfold with unprecedented spatial and temporal resolution. A principal challenge in this pursuit involves the delivery of samples to the X-ray interaction point in such a way that produces data of the highest possible quality and with maximal efficiency. This is hampered by intrinsic constraints posed by the light source and operation within a beamline environment.

Protein motions visualized by femtosecond time-resolved crystallography: The case of photosensory vs photosynthetic proteins.

Proteins are dynamic objects and undergo conformational changes when functioning. These changes range from interconversion between states in equilibrium to ultrafast and coherent structural motions within one perturbed state. Time-resolved serial femtosecond crystallography at free-electron X-ray lasers can unravel structural changes with atomic resolution and down to femtosecond time scales.

Investigation of Intestinal Absorption and Excretion of Paracetamol in Streptozotocin-Induced Hyperglycemia.

The phenolic drug molecules can be metabolized, among others, by the small intestine's enterocytes. The conjugation reactions (glucuronidation and sulfation) show great importance in these transformations, although the oxidation reactions can be significant. These processes are dependent on the substituents of the phenolic compounds or the reacting functional groups (hydroxyl or carboxyl).

The Cell-Wall β-d-Glucan in Leaves of Oat ( L.) Affected by Fungal Pathogen f. sp. .

In addition to the structural and storage functions of the (1,3; 1,4)-β-d-glucans (β-d-glucan), the possible protective role of this polymer under biotic stresses is still debated. The aim of this study was to contribute to this hypothesis by analyzing the β-d-glucans content, expression of related cellulose synthase-like () , , genes, content of chlorophylls, and β-1,3-glucanase content in oat ( L.) leaves infected with the commonly occurring oat fungal pathogen, f.

Soft gamma rays from low accreting supermassive black holes and connection to energetic neutrinos.

The Universe is filled with a diffuse background of MeV gamma-rays and PeV neutrinos, whose origins are unknown. Here, we propose a scenario that can account for both backgrounds simultaneously. Low-luminosity active galactic nuclei have hot accretion flows where thermal electrons naturally emit soft gamma rays via Comptonization of their synchrotron photons.

Systemic versus Oral and Systemic Antibiotic Prophylaxis (SOAP) study in colorectal surgery: prospective randomized multicentre trial.

Background: There is no consensus regarding the role of mechanical bowel preparation (MBP) and oral antibiotic prophylaxis (OABP) in reducing postoperative complications in colorectal surgery. The aim of this study was to examine the effect of OABP given in addition to MBP in the setting of a prospective randomized trial.

Methods: Patients awaiting elective colorectal surgery in four Hungarian colorectal centres were included in this multicentre, prospective, randomized, assessor-blinded study.

Hidden Cores of Active Galactic Nuclei as the Origin of Medium-Energy Neutrinos: Critical Tests with the MeV Gamma-Ray Connection.

Mysteries about the origin of high-energy cosmic neutrinos have deepened by the recent IceCube measurement of a large diffuse flux in the 10-100 TeV range. Based on the standard disk-corona picture of active galactic nuclei (AGN), we present a phenomenological model enabling us to systematically calculate the spectral sequence of multimessenger emission from the AGN coronae. We show that protons in the coronal plasma can be stochastically accelerated up to PeV energies by plasma turbulence, and find that the model explains the large diffuse flux of medium-energy neutrinos if the cosmic rays carry only a few percent of the thermal energy.

PICC-PORT totally implantable vascular access device in breast cancer patients undergoing chemotherapy.

Background And Objectives: The increasing use of arm totally implantable vascular access devices for breast cancer patients who require chemotherapy has led to a greater risk of complications and failures and, in particular, to upper extremity deep vein thrombosis. This study aims to investigate the outcomes of the arm peripherally inserted central catheter-PORT technique in breast cancer patients.

Methods: The peripherally inserted central catheter-PORT technique is an evolution of the standard arm-totally implantable vascular access device implant based on guided ultrasound venous access in the proximal third of the upper limb with subsequent placement of the reservoir at the middle third of the arm.

[Comparison of open and laparoscopic minor liver resections for malignant tumours - based on the experience of the first 50 cases].

Introduction: Laparoscopic resection of liver malignancies is gaining acceptance. Besides the advantages of minimally-invasive techniques, publications so far show no oncologic compromise of laparoscopy.

Aim: Our aim was to compare the results of our first fifty laparoscopic minor liver resections with traditional open procedures.

Molecular characterization and evolution of carnivorous sundew (Drosera rotundifolia L.) class V β-1,3-glucanase.

A gene for β-1,3-glucanase was isolated from carnivorous sundew. It is active in leaves and roots, but not in digestive glands. Analyses in transgenic tobacco suggest its function in germination.

Testing Einstein's Equivalence Principle With Fast Radio Bursts.

The accuracy of Einstein's equivalence principle (EEP) can be tested with the observed time delays between correlated particles or photons that are emitted from astronomical sources. Assuming as a lower limit that the time delays are caused mainly by the gravitational potential of the Milky Way, we prove that fast radio bursts (FRBs) of cosmological origin can be used to constrain the EEP with high accuracy. Taking FRB 110220 and two possible FRB/gamma-ray burst (GRB) association systems (FRB/GRB 101011A and FRB/GRB 100704A) as examples, we obtain a strict upper limit on the differences of the parametrized post-Newtonian parameter γ values as low as [γ(1.

[Not Available].

Unlabelled: A 35-year-old female presented with epigastric symptoms and fatigue. Gastroscopy revealed a 2 cm ulcerated lesion in the antrum region. Biopsy confirmed an invasive intestinal type adenocc.

Aesthetic evaluation in oncoplastic and conservative breast surgery: a comparative analysis.

Background: In conservative breast surgery, the achievement of a satisfactory cosmetic result could be challenging; oncoplastic techniques may be helpful in many cases. A comparative analysis was performed among 3 groups of patients undergoing oncoplastic techniques plus external radiation therapy or intraoperative radiotherapy (IORT) and breast conservative surgery plus external radiation therapy; long-term oncologic results in terms of disease relapse and aesthetic outcomes were compared.

Methods: Ninety-six patients were considered: 32 patients treated with oncoplastic surgery, 16 then subjected to radiotherapy (group 1) and another 16 treated with IORT (group 2); 64 patients treated by conservative surgery and radiotherapy formed the control group (group 3).

Youths as partners in a community participatory project for substance use prevention.

This community-based participatory research project aimed to develop strategies to prevent youth substance use in a rural county. This article (1) describes the project phases, (2) examines unique contributions and considerations of youth involvement, and (3) explores the youths' perspective. Twelve youths, aged 16 to 18 years, joined parents, community leaders, and research specialists on the community-based participatory research team.

Plant chitinase responses to different metal-type stresses reveal specificity.

Chitinases in Glycine max roots specifically respond to different metal types and reveal a polymorphism that coincides with sensitivity to metal toxicity. Plants evolved various defense mechanisms to cope with metal toxicity. Chitinases (EC 3.

[Metastatic malignant melanoma of the oesophagus: case report].

We report a case of metastatic malignant melanoma in the oesophagus. 13 years after the wide excision of primary skin melanoma, we found a polypoid tumor in the upper third of the oesophagus. Biopsy result was melanoma malignum.

Predictive factors of non-sentinel lymph node involvement in patients with invasive breast cancer and sentinel node micrometastases.

Patient-related, tumor-related, and sentinel node (SN)-related factors have been identified with the aim of predicting non-SN status in patients with SN micrometastases. According to our previous experience, primary tumor size (p=0.005) and the presence of lymphovascular invasion (LVI) (p=0.

Neutron-proton-converter acceleration mechanism at subphotospheres of relativistic outflows.

We study a type of particle acceleration that operates via neutron-proton conversion in inelastic nuclear collisions. This mechanism can be expected for relativistic shocks at subphotospheres if relativistic outflows contain neutrons. Using a test-particle approximation, we numerically calculate the energy spectrum and the efficiency of accelerated particles, and show that a good energy fraction of the nucleons can be accelerated.