Publications by authors named "Mesut Yigit"
Mucosal-associated invariant T (MAIT) cells play diverse roles in cancer, infectious diseases, and immunotherapy. This review explores their intricate involvement in cancer, from early detection to their dual functions in promoting inflammation and mediating anti-tumor responses. Within the solid tumor microenvironment (TME), MAIT cells can acquire an 'exhausted' state and secrete tumor-promoting cytokines.
View Article and Find Full Text PDFTargeting SARS-CoV-2 infection through CAR-T-like bispecific T cell engagers incorporating ACE2.
Clin Transl Immunology
October 2022
Article Synopsis
- - The study addresses the ongoing health challenges posed by COVID-19 and its variants, which lessen the effectiveness of current vaccines despite advances in antibody treatments and vaccines.
- - Researchers engineered T cells to target the SARS-CoV-2 Spike protein using a bispecific T cell engager called ACE2-Bite, which effectively kills infected cells and neutralizes various virus strains, including Delta and Omicron.
- - The findings indicate that ACE2-Bite could serve as a robust therapeutic strategy against future SARS-CoV-2 variants by harnessing the body’s adaptive immune response.
Article Synopsis
- Engineering immune cells with chimeric antigen receptors (CARs) shows promise in cancer treatment, particularly using a unique T cell subset known as mucosal-associated invariant T (MAIT) cells.
- In a study, researchers converted MAIT cells into CAR-T cells targeting B cell lymphoma and breast cancer, finding that these CAR-MAIT cells were highly effective against tumors, similar to traditional CD8 CAR-T cells but with lower IFN-γ production.
- Additionally, MAIT cells can be activated by a vitamin B metabolite to enhance their tumor-killing abilities, offering a novel, potentially more accessible approach to immunotherapy.
Article Synopsis
- - The study focuses on understanding the development of antibody protection against SARS-CoV-2, which is crucial for public health and vaccine creation.
- - Researchers created sensitive tests to detect specific IgG antibodies and neutralization capabilities in individuals infected with SARS-CoV-2, finding high antibody levels in infected patients compared to controls.
- - Results indicate that hospitalized patients have significantly higher antibody and neutralization levels than outpatients, revealing important insights into the antibody response and potential vaccine efficacy.
Article Synopsis
- The study focuses on the development of SARS-CoV-2-specific antibodies during infection, crucial for public health and vaccine design.
- Researchers created sensitive assays that detected high levels of IgG antibodies in all patients with confirmed COVID-19, while negative controls showed no antibodies.
- Results indicated hospitalized patients had significantly higher antibody and neutralization levels than outpatients, revealing insights into the immune response and potential vaccine effectiveness.