Monosaccharide coating modulate the intracellular trafficking of gold nanoparticles in dendritic cells.

Dendritic cells (DCs) have emerged as a promising target for drug delivery and immune modulation due to their pivotal role in initiating the adaptive immune response. Gold nanoparticles (AuNPs) have garnered interest as a platform for targeted drug delivery due to their biocompatibility, low toxicity and precise control over size, morphology and surface functionalization. Our investigation aimed to elucidate the intracellular uptake and trafficking of AuNPs coated with different combinations of monosaccharides (mannose, galactose, and fucose) in DCs.

Optimizing the viability, stability, and potency of Buffy coat isolated T cells for homologous dendritic cell co-cultures: A method for handling and preservation.

The utilization of T cells is becoming increasingly prominent in both clinical and research domains. However, the need to optimize preservation methodologies for extended periods of time remains unmet. To address this issue, we have developed a protocol for the handling and preservation of T cells that facilitates successful donor homologous co-cultures with dendritic cells (DCs), and preserves the cells for subsequent testing.

Factors and Determinants for Uptake of COVID-19 Vaccine in a Medical University in Riyadh, Saudi Arabia.

Background The coronavirus disease 2019 (COVID-19), which is also known as severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), is an infection that is caused by the novel coronavirus. COVID-19 has severely affected the public health by causing more than 200 million cases and four million deaths worldwide. There are, presently, no specific antiviral treatments for COVID-19.

Knowledge, Attitude, and Practice Toward Prostate Cancer and Its Screening Methods Among Primary Care Patients in King Abdulaziz Medical City, Riyadh, Saudi Arabia.

Aim The aim of the study was to evaluate the knowledge, attitude, and practice toward prostate cancer and its screening methods among patients attending primary care facilities in King Abdulaziz Medical City (KAMC) in Riyadh, Saudi Arabia. Materials and methods A cross-sectional survey was conducted on a random sample of 385 men. The questionnaire was distributed using a non-random sampling method (convenience sampling) that included 13 questions that assess the knowledge, attitude, and practice of adult male patients toward prostate cancer and its screening methods.

The Cross-Talk between miR-511-3p and C-Type Lectin Receptors on Dendritic Cells Affects Dendritic Cell Function.

MicroRNAs are small, noncoding RNAs that function as posttranscriptional modulators of gene expression by binding target mRNAs and inhibiting translation. They are therefore crucial regulators of several biological as well as immunological events. Recently, miR-511-3p has been implicated in the development and differentiation of APCs, such as dendritic cells (DCs), and regulating several human diseases.