Publications by authors named "Merzuka Kalay"
Emerging evidence suggests that gastrointestinal dysfunction and enteric nervous system pathology play a critical role in the early stages of Parkinson's disease. Considering the bidirectional relationship between gastrointestinal symptoms and mood disorders, this study aimed to elucidate the effects and possible mechanisms of action of vortioxetine, a serotonergic antidepressant, on the pathophysiological changes induced by rotenone in the enteroglial cells. α-synuclein, phosphorylated α-synuclein, TLR2, S100B and RAGE expression were detected in duodenal tissues of rats administered rotenone (2 mg/kg/day, s.
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- Tuberculosis, caused by Mycobacterium tuberculosis, is a significant global health issue, and rising drug resistance highlights the urgent need for new treatments.
- Computer-aided drug design (CADD) is being utilized to create more effective and less toxic drugs for tuberculosis.
- The study focused on two synthetic peptides, AKVUAM-1 and AKVUAM-2, which were designed to block interactions crucial for M. tuberculosis infection, showing promise without harming normal lung tissue and having varied minimum inhibitory concentrations (MIC) against different bacterial strains.